Stereospecific binding of MRI contrast agents to human serum albumin: the case of Gd-(S)-EOB-DTPA (Eovist) and its (R) isomer

2001 ◽  
Vol 6 (2) ◽  
pp. 196-200 ◽  
Author(s):  
Luce Vander Elst ◽  
Florence Chapelle ◽  
Sophie Laurent ◽  
Robert N. Muller
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agents ◽  
Human Serum ◽  
Mri Contrast Agents ◽  
Mri Contrast

scholarly journals The presence of halide salts influences the non-covalent interaction of MRI contrast agents and human serum albumin

2007 ◽  
Vol 2 (5) ◽  
pp. 258-261 ◽  
Author(s):  
Virginie Henrotte ◽  
Robert N. Muller ◽  
Annick Bartholet ◽  
Luce Vander Elst
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agents ◽  
Human Serum ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Covalent Interaction ◽  
Halide Salts

scholarly journals Human Serum Albumin Labelled with Sterically-Hindered Nitroxides as Potential MRI Contrast Agents

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1709 ◽  
Author(s):  
Sergey Dobrynin ◽  
Sergei Kutseikin ◽  
Denis Morozov ◽  
Olesya Krumkacheva ◽  
Anna Spitsyna ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agents ◽  
Human Serum ◽  
Biological Properties ◽  
Mri Contrast Agents ◽  
Organic Radical ◽  
Mri Contrast ◽  
New Family ◽  
Magnetic Resonance Imaging Mri

Four albumin-nitroxide conjugates were prepared and tested as metal-free organic radical contrast agents (ORCAs) for magnetic resonance imaging (MRI). Each human serum albumin (HSA) carrier bears multiple nitroxides conjugated via homocysteine thiolactones. These molecular conjugates retain important physical and biological properties of their HSA component, and the resistance of their nitroxide groups to bioreduction was retained or enhanced. The relaxivities are similar for these four conjugates and are much greater than those of their individual components: the HSA or the small nitroxide molecules. This new family of conjugates has excellent prospects for optimization as ORCAs.

scholarly journals Contrast Enhancement of the Brain by Folate-Conjugated Gadolinium–Diethylenetriaminepentaacetic Acid–Human Serum Albumin Nanoparticles by Magnetic Resonance Imaging

2012 ◽  
Vol 11 (4) ◽  
pp. 7290.2011.00047 ◽  
Author(s):  
Huedayi Korkusuz ◽  
Karsten Ulbrich ◽  
Verena Bihrer ◽  
Katerina Welzel ◽  
Valery Chernikov ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agents ◽  
Diethylenetriaminepentaacetic Acid ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
The Brain ◽  
Signal Intensities

Different from regular small molecule contrast agents, nanoparticle-based contrast agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties. We evaluated the tissue distribution of polymeric nanoparticles (NPs) prepared from human serum albumin (HSA), loaded with gadolinium–diethylenetriaminepentaacetic acid (Gd-DTPA) (Gd-HSA-NP), and coated with folic acid (FA) (Gd-HSA-NP-FA) in mice by magnetic resonance imaging (MRI). FA increases the affinity of the Gd-HSA-NP to FA receptor–expressing cells. Clinical 3 T MRI was used to evaluate the signal intensities in the different organs of mice injected with Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-FA. Signal intensities were measured and standardized by calculating the signal to noise ratios. In general, the NP-based contrast agents provided stronger contrasting than Gd-DTPA. Gd-HSA-NP-FA provided a significant contrast enhancement (CE) in the brain ( p = .0032), whereas Gd-DTPA or Gd-HSA-NP did not. All studied MRI contrast agents showed significant CE in the blood, kidney, and liver ( p < .05). Gd-HSA-NP-FA elicited significantly higher CE in the blood than Gd-HSA-NP ( p = .0069); Gd-HSA-NP and Gd-HSA-NP-FA did not show CE in skeletal muscle and gallbladder; Gd-HSA-NP, but not Gd-HSA-NP-FA, showed CE in the cardiac muscle. Gd-HSA-NP-FA has potential as an MRI contrast agent in the brain.

Influence of Human Serum Albumin on Longitudinal and Transverse Relaxation Rates (R1 and R2) of Magnetic Resonance Contrast Agents

2006 ◽  
Vol 41 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Frederik L. Giesel ◽  
Hendrik von Tengg-Kobligk ◽  
Iain D. Wilkinson ◽  
Peter Siegler ◽  
Claus W. von der Lieth ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agents ◽  
Human Serum ◽  
Relaxation Rates ◽  
Transverse Relaxation ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast

An albumin-binding Gd-HPDO3A contrast agent for improved intravascular retention

2021 ◽  
Author(s):  
Louise R Tear ◽  
Carla Carrera ◽  
Chetan Bharatkumar Dhakan ◽  
Eleonora Cavallari ◽  
Fabio Travagin ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Human Serum ◽  
Retention Time ◽  
Albumin Binding ◽  
Gadolinium Contrast ◽  
Gadolinium Contrast Agents

Gadolinium contrast agents that bind to human serum albumin (HSA) can achieve significantly higher relaxivity values and show improved vascular retention time. Most contrast agents of this design are linear...

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