scholarly journals In vitro characterization of a synthetic calcium phosphate bone graft on periodontal ligament cell and osteoblast behavior and its combination with an enamel matrix derivative

2013 ◽  
Vol 18 (2) ◽  
pp. 443-451 ◽  
Author(s):  
Richard J. Miron ◽  
Dieter D. Bosshardt ◽  
Anja C. Gemperli ◽  
Michel Dard ◽  
Daniel Buser ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Periodontal Ligament ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Periodontal Ligament Cell ◽  
In Vitro Characterization ◽  
Synthetic Calcium Phosphate ◽  
Matrix Derivative

Enamel Matrix Derivative Promotes Human Periodontal Ligament Cell Differentiation and Osteoprotegerin Production in vitro

2007 ◽  
Vol 86 (10) ◽  
pp. 980-985 ◽  
Author(s):  
S. Lossdörfer ◽  
M. Sun ◽  
W. Götz ◽  
M. Dard ◽  
A. Jäger
Keyword(s):  
Cell Differentiation ◽  
Periodontal Ligament ◽  
Cell Number ◽  
Enamel Matrix Derivative ◽  
Periodontal Ligament Cells ◽  
Enamel Matrix ◽  
Periodontal Ligament Cell ◽  
Local Factor ◽  
Matrix Derivative

Enamel matrix derivative (EMD) has been used successfully to aid periodontal repair. We sought to elucidate the mechanism of action of EMD and hypothesized that combined exposure to EMD and parathyroid hormone (PTH), which acts anabolicly when administered intermittently, would enhance periodontal ligament cell proliferation, differentiation, and local factor production. Confluent human periodontal ligament cells were exposed to EMD continuously or to PTH(1-34) intermittently, or a combination of both. Cell number, alkaline phosphatase activity, osteocalcin, and osteoprotegerin production were determined. Continuous challenge with EMD resulted in an increase of the differentiation parameters and osteoprotegerin production, while simultaneously inhibiting proliferation. Intermittent PTH(1-34) administration exerted opposite effects. Combined administration of EMD and PTH(1-34) weakened or even nullified the effects seen for the agents alone. These results suggest that EMD promotes periodontal ligament cell differentiation and osteoprotegerin production, potentially resulting in a microenvironment supporting periodontal repair, whereas combining EMD and PTH(1-34) failed to prove beneficial in this respect.

scholarly journals In vitro studies on periodontal ligament cells and enamel matrix derivative

1997 ◽  
Vol 24 (9) ◽  
pp. 685-692 ◽  
Author(s):  
Stina Gestrelius ◽  
Christer Andersson ◽  
Dagny Lidstrom ◽  
Lars Hammarstrom ◽  
Martha Somerman
Keyword(s):  
Periodontal Ligament ◽  
In Vitro Studies ◽  
Enamel Matrix Derivative ◽  
Periodontal Ligament Cells ◽  
Enamel Matrix ◽  
Matrix Derivative

Effects of Enamel Matrix Derivative on Bone-Related mRNA Expression in Human Periodontal Ligament Cells In Vitro

2006 ◽  
Vol 77 (5) ◽  
pp. 891-898 ◽  
Author(s):  
Kazuaki Takayanagi ◽  
Ginko Osawa ◽  
Hiroshi Nakaya ◽  
David L. Cochran ◽  
Kyuich Kamoi ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Periodontal Ligament ◽  
Enamel Matrix Derivative ◽  
Periodontal Ligament Cells ◽  
Enamel Matrix ◽  
Human Periodontal Ligament Cells ◽  
Matrix Derivative

Effect of Enamel Matrix Derivative on Periodontal Ligament Cells In Vitro Is Diminished byPorphyromonas gingivalis

2004 ◽  
Vol 75 (6) ◽  
pp. 858-865 ◽  
Author(s):  
Hiroaki Inaba ◽  
Shinji Kawai ◽  
Koji Nakayama ◽  
Nobuo Okahashi ◽  
Atsuo Amano
Keyword(s):  
Periodontal Ligament ◽  
Enamel Matrix Derivative ◽  
Periodontal Ligament Cells ◽  
Enamel Matrix ◽  
Matrix Derivative

In vitro studies on human periodontal ligament stem cell sheets enhanced by enamel matrix derivative

2016 ◽  
Vol 141 ◽  
pp. 102-111 ◽  
Author(s):  
Zhongshan Wang ◽  
Zhihong Feng ◽  
Guofeng Wu ◽  
Shizhu Bai ◽  
Yan Dong ◽  
...  
Keyword(s):  
Stem Cell ◽  
Periodontal Ligament ◽  
In Vitro Studies ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Cell Sheets ◽  
Periodontal Ligament Stem Cell ◽  
Matrix Derivative

The Influence of Enamel Matrix Derivative Associated With Insulin-Like Growth Factor-I on Periodontal Ligament Fibroblasts

2004 ◽  
Vol 75 (4) ◽  
pp. 498-504 ◽  
Author(s):  
Daniela B. Palioto ◽  
Ricardo D. Coletta ◽  
Edgard Graner ◽  
Julio Cesar Joly ◽  
Antonio Fernando Martorelli de Lima
Keyword(s):  
Growth Factor ◽  
Periodontal Ligament ◽  
Enamel Matrix Derivative ◽  
Insulin Like Growth Factor ◽  
Enamel Matrix ◽  
Periodontal Ligament Fibroblasts ◽  
Factor I ◽  
Growth Factor I ◽  
Matrix Derivative
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