Bidirectional association between autism spectrum disorder and epilepsy in child and adolescent patients: a population-based cohort study

2016 ◽  
Vol 25 (9) ◽  
pp. 979-987 ◽  
Author(s):  
Chien-Chou Su ◽  
Mei Hung Chi ◽  
Shin-Hsien Lin ◽  
Yen Kuang Yang
Keyword(s):  
Autism Spectrum Disorder ◽  
Cohort Study ◽  
Child And Adolescent ◽  
Population Based ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Bidirectional Association ◽  
Adolescent Patients

scholarly journals The bidirectional association between sleep problems and autism spectrum disorder: a population-based cohort study

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Maria E. Verhoeff ◽  
Laura M. E. Blanken ◽  
Desana Kocevska ◽  
Viara R. Mileva-Seitz ◽  
Vincent W. V. Jaddoe ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Cohort Study ◽  
Sleep Problems ◽  
Population Based ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Bidirectional Association

scholarly journals Risk of autism spectrum disorder in offspring following paternal use of selective serotonin reuptake inhibitors before conception: a population-based cohort study

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e016368 ◽  
Author(s):  
Fen Yang ◽  
Jianping Chen ◽  
Mao-Hua Miao ◽  
Wei Yuan ◽  
Lin Li ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Cohort Study ◽  
Affective Disorders ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Population Based ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Selective Serotonin ◽  
Increased Risk

ObjectiveThe present study aimed to examine the association between paternal selective serotonin reuptake inhibitor (SSRI) use before conception and the risk of autism spectrum disorder (ASD) in offspring.DesignA population-based cohort study.MethodsWe conducted a cohort study of 669 922 children born from 1998 to 2008, with follow-up throughout 2013. Based on Danish national registers, we linked information on paternal use of SSRIs, ASD diagnosed in children and a range of potential confounders. The children whose fathers used SSRIs during the last 3 months prior to conception were identified as the exposed. Cox regression model was used to estimate the HR for ASD in children.ResultsCompared with unexposed children, the exposed had a 1.62-fold higher risk of ASD (95% CI 1.33 to 1.96) and the risk attenuated after adjusting for potential confounders, especially fathers’ psychiatric conditions (HR=1.43, 95% CI 1.18 to 1.74). When extending the exposure window to 1 year before conception, the increased risk persisted in children of fathers using SSRIs only from the last year until the last 3 months prior to conception (HR=1.54, 95% CI 1.21 to 1.94) but not in children of fathers using SSRIs only during the last 3 months prior to conception (HR=1.17, 95% CI 0.75 to 1.82). We also performed stratified analyses according to paternal history of affective disorders and observed no increased ASD risk among children whose father had affective disorders. Besides, the sibling analysis showed that the ASD risk did not increase among exposed children compared with their unexposed siblings.ConclusionsThe mildly increased risk of ASD in the offspring associated with paternal SSRI use before conception may be attributable to paternal underlying psychiatric indications related to SSRI use or other unmeasured confounding factors.

scholarly journals Timing of Identification Among Children With an Autism Spectrum Disorder: Findings From a Population-Based Surveillance Study

2009 ◽  
Vol 48 (5) ◽  
pp. 474-483 ◽  
Author(s):  
Paul T. Shattuck ◽  
Maureen Durkin ◽  
Matthew Maenner ◽  
Craig Newschaffer ◽  
David S. Mandell ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Population Based ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Surveillance Study
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