An innovative synergistic grid approach to the computational study of protein aggregation mechanisms

2014 ◽  
Vol 20 (7) ◽  
Author(s):  
Noelia Faginas-Lago ◽  
Margarita Albertí ◽  
Alessandro Costantini ◽  
Antonio Laganà ◽  
Andrea Lombardi ◽  
...  
2012 ◽  
Vol 5 (1) ◽  
pp. 11-21 ◽  
Author(s):  
S. Deng ◽  
B. W. van Oudheusden ◽  
T. Xiao ◽  
H. Bijl

The influence of a propeller on the aerodynamic performance of an MAV is investigated using an unstructured overset grid technique. The flow regime of a fixed-wing MAV powered by a propeller contains both incompressible regions due to the low flight speed, as well as compressible flow areas near the propeller-tip region. In order to simulate all speed flow efficiently, a dual-time preconditioning method is employed in the present study. The methodology in this paper is verified as providing a reliable numerical simulation tool for all flow regimes, in the additional presence of moving boundaries, which is treated with an overset grid approach.


2015 ◽  
Vol 108 (2) ◽  
pp. 495a
Author(s):  
David Shorthouse ◽  
Thomas Gallagher ◽  
Mark Sansom

Author(s):  
James R. Gaylor ◽  
Fredda Schafer ◽  
Robert E. Nordquist

Several theories on the origin of the melanosome exist. These include the Golgi origin theory, in which a tyrosinase-rich protein is "packaged" by the Golgi apparatus, thus forming the early form of the melanosome. A second theory postulates a mitochondrial origin of melanosomes. Its author contends that the melanosome is a modified mitochondria which acquires melanin during its development. A third theory states that a pre-melanosome is formed in the smooth or rough endoplasmic reticulum. Protein aggregation is suggested by one author as a possible source of the melanosome. This fourth theory postulates that the melanosome originates when the protein products of several genetic loci aggregate in the cytoplasm of the melanocyte. It is this protein matrix on which the melanin is deposited. It was with these theories in mind that this project was undertaken.


2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
R Krüger ◽  
FP Marx ◽  
D Berg ◽  
C Holzmann ◽  
T Müller ◽  
...  

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