Molecular Modeling as a Powerful Tool for the Mapping of Fibroblast Growth Factor Receptor-1 Ligand Binding Determinants

1999 ◽  
Vol 5 (4) ◽  
pp. 90-96
Author(s):  
Sérgio Oyama Jr. ◽  
M. Terêsa M. Miranda ◽  
Sumika Kiyota ◽  
Angelo G. Gambarini
Keyword(s):  
Molecular Modeling ◽  
Growth Factor ◽  
Ligand Binding ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Binding Determinants

scholarly journals Novel Regulatory Factors and Small-Molecule Inhibitors of FGFR4 in Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanan Liu ◽  
Canwei Wang ◽  
Jifa Li ◽  
Jiandong Zhu ◽  
Chengguang Zhao ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ligand Binding ◽  
Fibroblast Growth Factor ◽  
Small Molecule ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Cancer Development ◽  
Tyrosine Kinase Receptor ◽  
Fibroblast Growth ◽  
Receptor Family

Fibroblast growth factor receptor 4 (FGFR4) is a tyrosine kinase receptor that is a member of the fibroblast growth factor receptor family and is stimulated by highly regulated ligand binding. Excessive expression of the receptor and its ligand, especially FGF19, occurs in many types of cancer. Abnormal FGFR4 production explains these cancer formations, and therefore, this receptor has emerged as a potential target for inhibiting cancer development. This review discusses the diverse mechanisms of oncogenic activation of FGFR4 and highlights some currently available inhibitors targeting FGFR4.

Solution Structure of the Ligand Binding Domain of the Fibroblast Growth Factor Receptor:  Role of Heparin in the Activation of the Receptor†,‡

Biochemistry ◽  
2005 ◽  
Vol 44 (48) ◽  
pp. 15787-15798 ◽  
Author(s):  
Kuo-Wei Hung ◽  
Thallapuranam Krishnaswamy S. Kumar ◽  
Karuppanan Muthusamy Kathir ◽  
Ping Xu ◽  
Feng Ni ◽  
...  
Keyword(s):  
Growth Factor ◽  
Ligand Binding ◽  
Fibroblast Growth Factor ◽  
Solution Structure ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Fibroblast Growth
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