Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank

Hernia ◽  
2021 ◽  
Author(s):  
J. Wei ◽  
M. Attaar ◽  
Z. Shi ◽  
R. Na ◽  
W. K. Resurreccion ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Abdominal Wall Hernia ◽  
Clinical Implications ◽  
Uk Biobank ◽  
The Uk

scholarly journals P48 Exploration of variation in Management of Acutely Symptomatic Hernia – results from the MASH practice survey

BJS Open ◽  
2021 ◽  
Vol 5 (Supplement_1) ◽  
Author(s):  
O Spence ◽  
V Proctor ◽  
A Sayers ◽  
S Green ◽  
F Burns ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Abdominal Wall ◽  
Open Repair ◽  
Response Rate ◽  
Abdominal Wall Hernia ◽  
Suture Repair ◽  
Emergency Setting ◽  
Repair Strategy ◽  
The Uk ◽  
Minimal Evidence

Abstract Introduction There is minimal evidence to guide the emergency management of groin and abdominal wall hernia. The aim of this project is to understand current variations in clinical practice across the UK when managing common types of acutely symptomatic hernia. Methods A survey of clinical practice was developed to explore the management of acutely symptomatic abdominal wall hernia (ASH) including groin (GH), umbilical (UH), and incisional hernia (IH). The survey captured respondent characteristics. It explored preferences in the management of each type of ASH, including factors related to treatment and repair strategy. Surgeons at ST3+ level with a UK practice were invited to participate through Twitter and collaborative networks. Results In total, 144 responses were received (response rate 26%). Of these, 62 (43.1%) were Consultant Surgeons, 105 (72.9%) did not have a specialist hernia practice, and 95 (66%) did not follow specific guidelines for emergency hernia repair. There was variation in investigations used e.g. CT required for IH (91%) but less for GH (34.7%) and UH (47.2%). Open repair was preferred in all settings. For GH with ischaemic bowel 76 (52.8%) would suture repair vs. 67 (46.5%) who would use a mesh (64.2% permanent synthetic) this is similar for IH, where 59 (41%) chose suture vs. 71 (49.3%) mesh, although 61.9% favoured biologic mesh for IH. Suture repair was preferred for UH with ischaemic bowel (69.4%). Conclusion The survey demonstrates variation in treatment of ASH. Areas which require further exploration include use of mesh and laparoscopy in the emergency setting.

Traumatic Abdominal Wall Hernia: Epidemiology and Clinical Implications

2006 ◽  
Vol 61 (5) ◽  
pp. 1058-1061 ◽  
Author(s):  
Fernando A. C. Spencer Netto ◽  
Paul Hamilton ◽  
Sandro B. Rizoli ◽  
Bartolomeu Nascimento ◽  
Frederick D. Brenneman ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Abdominal Wall Hernia ◽  
Clinical Implications ◽  
Traumatic Abdominal Wall Hernia

scholarly journals Outcomes of obstructed abdominal wall hernia: results from the UK national small bowel obstruction audit

BJS Open ◽  
2020 ◽  
Vol 4 (5) ◽  
pp. 924-934
Author(s):  
◽  
Matthew J Lee ◽  
Thomas M Drake ◽  
Adele E Sayers ◽  
Ciaran J Walsh ◽  
...  
Keyword(s):  
Small Bowel ◽  
Small Bowel Obstruction ◽  
Abdominal Wall ◽  
Bowel Obstruction ◽  
Abdominal Wall Hernia ◽  
The Uk

Low birthweight is associated with poorer limb muscle mass and grip strength in middle age: findings from the UK Biobank Imaging Enhancement

2019 ◽  
Author(s):  
Elizabeth Curtis ◽  
Justin Liu ◽  
Kate Ward ◽  
Karen Jameson ◽  
Zahra Raisi-Estabragh ◽  
...  
Keyword(s):  
Grip Strength ◽  
Muscle Mass ◽  
Low Birthweight ◽  
Middle Age ◽  
Limb Muscle ◽  
Uk Biobank ◽  
The Uk

What Can Complex Abdominal Wall Hernia Surgeons Learn About Quality of Life From Ancient Greek Philosophers?

2020 ◽  
Vol 03 (03) ◽  
Author(s):  
Olivia Smith ◽  
Miriam Isaac ◽  
Thomas Elanjithara ◽  
Praminthra Chitsabesan ◽  
Srinivas Chintapatla
Keyword(s):  
Quality Of Life ◽  
Abdominal Wall ◽  
Abdominal Wall Hernia ◽  
Ancient Greek

Contrasting Broad- and Clinically- defined Polygenic Indicators of Depression and Depression-related Phenotypes in Adults and Children

2020 ◽  
Author(s):  
John E. McGeary ◽  
Chelsie Benca-Bachman ◽  
Victoria Risner ◽  
Christopher G Beevers ◽  
Brandon Gibb ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Cognitive Reappraisal ◽  
Twin Studies ◽  
European Ancestry ◽  
Summary Statistics ◽  
Depression Severity ◽  
Uk Biobank ◽  
Polygenic Scores ◽  
Adults And Children ◽  
The Uk

Twin studies indicate that 30-40% of the disease liability for depression can be attributed to genetic differences. Here, we assess the explanatory ability of polygenic scores (PGS) based on broad- (PGSBD) and clinical- (PGSMDD) depression summary statistics from the UK Biobank using independent cohorts of adults (N=210; 100% European Ancestry) and children (N=728; 70% European Ancestry) who have been extensively phenotyped for depression and related neurocognitive phenotypes. PGS associations with depression severity and diagnosis were generally modest, and larger in adults than children. Polygenic prediction of depression-related phenotypes was mixed and varied by PGS. Higher PGSBD, in adults, was associated with a higher likelihood of having suicidal ideation, increased brooding and anhedonia, and lower levels of cognitive reappraisal; PGSMDD was positively associated with brooding and negatively related to cognitive reappraisal. Overall, PGS based on both broad and clinical depression phenotypes have modest utility in adult and child samples of depression.

Clinical and Biochimical Comorbidities and Complications in Abdominal Surgery Using Synthetic Prosthetic Material

2018 ◽  
Vol 69 (6) ◽  
pp. 1519-1523
Author(s):  
Vlad Dumitru Baleanu ◽  
Danut Vasile ◽  
Alexandru Marian Goganau ◽  
Paul Ioan Tomescu ◽  
Dragos Davitoiu ◽  
...  
Keyword(s):  
Inguinal Hernia ◽  
Abdominal Wall ◽  
Abdominal Wall Hernia ◽  
Prosthetic Material ◽  
Hernia Surgery ◽  
Tension Free ◽  
Elective Repair ◽  
Scrotal Edema ◽  
Remarkable Recovery ◽  
Risks Assessment

Hernia can be defined as an organ disorder which protrudes the wall that contains it. Synthetic material for the repair of the abdominal wall are used frequently with good results and less complications. Our research included a number of 135 patients diagnosed with inguinal hernia hospitalized and operated in Clinical County Hospital of Craiova, between 1st January 2017-31 October 2017. The purpose of our work was to identify and analyze comorbidities and complications for inguinal hernia repaired with synthetic prosthetic material. hernia repair was performed in 135 patients, 16 were women and 119 were men. Tension free meshplasty was accomplished in 131 patients with uncomplicated inguinal hernia and herniorrhaphy was successfully performed at 4 patients with complicated inguinal hernia. From our study 107 patients had a remarkable recovery without any complication. Patients who underwent tension-free hernia surgery using prosthetic mesh,short-term complications were represented by 19 patients with urinary retention, 6 surgical local infection (superficial infections) and 2 scrotal edema. Nowadays surgeons try to find the best elective repair of inguinal hernia,to be safety for the patients despite of their age and with few complications and low mortality rate. Risks assessment include general conditions and associated comorbidities of the patients. In our study we reveal the type of comorbidities which we meet. We considered that it is significant to optimize cardiopulmonary status and the other comorbidities of the patient before to repair abdominal wall hernia in order to avoid both short and long term complication.

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