Genotype–phenotype correlations of heterozygous HTRA1-related cerebral small vessel disease: case report and systematic review

Neurogenetics ◽  
2021 ◽  
Author(s):  
Haohan Zhang ◽  
Xiaoming Qin ◽  
Yingying Shi ◽  
Xinya Gao ◽  
Fengyu Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Disease Case

scholarly journals Inflammation and cerebral small vessel disease: A systematic review

2019 ◽  
Vol 53 ◽  
pp. 100916 ◽  
Author(s):  
Audrey Low ◽  
Elijah Mak ◽  
James B. Rowe ◽  
Hugh S. Markus ◽  
John T. O’Brien
Keyword(s):  
Systematic Review ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta‐analysis

2020 ◽  
Author(s):  
Olivia K. L. Hamilton ◽  
Ellen V. Backhouse ◽  
Esther Janssen ◽  
Angela C. C. Jochems ◽  
Caragh Maher ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cognitive Impairment ◽  
Small Vessel Disease ◽  
Meta Analysis ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Do in vivo Experimental Models Reflect Human Cerebral Small Vessel Disease? a Systematic Review

2008 ◽  
Vol 28 (12) ◽  
pp. 1877-1891 ◽  
Author(s):  
Atticus H Hainsworth ◽  
Hugh S Markus
Keyword(s):  
Systematic Review ◽  
White Matter ◽  
Small Vessel Disease ◽  
Experimental Models ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Genetic Mutations ◽  
Ischaemic Injury ◽  
Vessel Disease ◽  
Diffuse White Matter

Cerebral small vessel disease (SVD) is a major cause of stroke and dementia. Pathologically, three lesions are seen: small vessel arteriopathy, lacunar infarction, and diffuse white matter injury (leukoaraiosis). Appropriate experimental models would aid in understanding these pathologic states and also in preclinical testing of therapies. The objective was to perform a systematic review of animal models of SVD and determine whether these resemble four key clinicopathologic features: (1) small, discrete infarcts; (2) small vessel arteriopathy; (3) diffuse white matter damage; (4) cognitive impairment. Fifteen different models were included, under four categories: (1) embolic injuries (injected blood clot, photochemical, detergent-evoked); (2) hypoperfusion/ischaemic injury (bilateral common carotid occlusion/stenosis, striatal endothelin-1 injection, striatal mitotoxin 3-NPA); (3) hypertension-based injuries (surgical narrowing of the aorta, or genetic mutations, usually in the renin-angiotensin system); (4) blood vessel damage (injected proteases, endothelium-targeting viral infection, or genetic mutations affecting vessel walls). Chronic hypertensive models resembled most key features of SVD, and shared the major risk factors of hypertension and age with human SVD. The most-used model was the stroke-prone spontaneously hypertensive rat (SHR-SP). No model described all features of the human disease. The optimal choice of model depends on the aspect of pathophysiology being studied.

Cerebral small vessel disease and the risk of Alzheimer’s disease: A systematic review

2018 ◽  
Vol 47 ◽  
pp. 41-48 ◽  
Author(s):  
Yue Liu ◽  
Nady Braidy ◽  
Anne Poljak ◽  
Daniel K.Y. Chan ◽  
Perminder Sachdev
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease
Sign in / Sign up

Export Citation Format

Share Document