Anti-apolipoprotein A-1 antibodies and carotid intima–media thickness in Egyptian women with systemic lupus erythematosus

2013 ◽  
Vol 33 (4) ◽  
pp. 493-498 ◽  
Author(s):  
M. M. Radwan ◽  
D. El-Lebedy ◽  
R. Fouda ◽  
E. Elsorougy ◽  
D. Fakhry
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Systemic Lupus ◽  
Media Thickness ◽  
Apolipoprotein A ◽  
Egyptian Women

scholarly journals Risk factors for progression of carotid intima-media thickness in patients with systemic lupus erythematosus: protocol for an observational cohort study in China

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e030721
Author(s):  
Haiyu Pang ◽  
Yicong Ye ◽  
Faming Ding ◽  
Mengtao Li ◽  
Xinglin Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Informed Consent ◽  
Lupus Erythematosus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Systemic Lupus ◽  
Media Thickness ◽  
Artery Disease

IntroductionAccelerated atherosclerosis is a major complication of systemic lupus erythematosus (SLE), and it leads to increased cardiovascular morbidity and mortality in patients with SLE. This study aimed to investigate the natural progression of carotid intima-media thickness (CIMT), and to examine the risk factors for progression of CIMT and atherosclerotic plaques based on a Chinese SLE cohort.Methods and analysisParticipants were continuously enrolled as outpatients of the Department of Rheumatology in Peking Union Medical College Hospital (PUMCH) from October 2013 to December 2016. Inclusion criteria were as follows: (1) age ≥18 years, (2) fulfilment of clinical classification criteria of SLE and (3) provision of signed written informed consent. Patients with clinically overt coronary artery disease, a history of cardiovascular disease (previous stroke, heart failure, myocardial infarction, angina or symptomatic peripheral artery disease) and malignancy, and pregnant/lactating women were excluded. The primary outcome is progression of CIMT from baseline. A total of 440 patients with SLE will be enrolled. Participants will receive follow-up surveys ~5 years after their baseline visit. A standard structural survey form, including demographic data, medical history, clinical and laboratory assessments and CIMT measurement, is planned for data collection at baseline and follow-up. The risk prediction model for progression of CIMT will be created by using a mixed effect model.Ethics and disseminationThe study protocol was approved by the institutional review board of PUMCH (S-599). Informed consent was obtained from all participants according to the Declaration of Helsinki on Biomedical Research Involving Human Studies. All data will be managed confidentially according to guidelines and legislation. Dissemination will include publication of scientific papers and/or presentations of the study findings at international conferences.

scholarly journals Korelasi Kadar Serum Leptin dengan Aterosklerosis pada Pasien Systemic Lupus Erythematosus Wanita

2017 ◽  
Vol 1 (1) ◽  
pp. 17-21
Author(s):  
Andi Manaek ◽  
Gede Kambayana
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Doppler Ultrasound ◽  
Lupus Erythematosus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Systemic Lupus ◽  
Serum Leptin ◽  
Media Thickness ◽  
Simple Sampling

Penyakit kardiovaskular adalah penyebab kematian tertinggi di dunia. SLE diduga berkontribusi kuat mempercepat timbulnya aterosklerosis. Baru-baru ini, banyak bukti ditemukan berhubung dengan efek hormon pada sistem imun termasuk efeknya pada penyakit autoimun. Leptin dikenal sebagai hormon yang menyerupai sitokin dengan aksi pleiotropik dalam memodulasi respon imun. Penelitian yang dilakukan sebelumnya mendapatkan level leptin yang tinggi pada pasien SLE dengan plak aterosklerosis namun berkorelasi lemah dengan carotid Intima Media Thickness (cIMT). Tujuan penelitian ini yaitu untuk mengetahui korelasi serum leptin dengan aterosklerosis pada pasien SLE. Penelitian dilakukan dengan disain analitik potong lintang. Pengambilan sampel dilakukan dengan metode simple sampling. Konsentrasi serum leptin diperiksa dengan menggunakan metode ELISA dan aterosklerosis diperiksa dengan mesin Duplex carotid-intima Doppler Ultrasound oleh satu orang dokter spesialis radiologi. Analisis statistik menggunakan uji korelasi Spearman. Tingkat kemaknaan jika p < 0,05. Sebanyak 54 orang pasien SLE wanita diikutkan dalam penelitian. Rerata kadar serum leptin  adalah 203,83 ± 179,06 ng/ml. Pada pasien didapatkan rerata CIMT adalah 0,48 ± 0,12 mm dengan frekuensi yang mendapat plak 5,5% dan tidak plak 92,7%. Terdapat korelasi lemah antara kadar serum leptin dengan aterosklerosis dalam hal ini yaitu CIMT (r = 0,028; p = 0,843) dan plak (r = 0,008; p = 0,955), tetapi secara statistik tidak bermakna (p < 0,05). Pada penelitian ini tidak didapatkan korelasi antara kadar serum leptin dengan aterosklerosis pada pasien SLE wanita.

Increased serum leptin levels are associated with metabolic syndrome and carotid intima media thickness in premenopausal systemic lupus erythematosus patients without clinical atherosclerotic vascular events

Lupus ◽  
2018 ◽  
Vol 27 (9) ◽  
pp. 1509-1516 ◽  
Author(s):  
S Demir ◽  
G Erten ◽  
B Artım-Esen ◽  
Y Şahinkaya ◽  
Ö Pehlivan ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Metabolic Syndrome ◽  
Lupus Erythematosus ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Systemic Lupus ◽  
Media Thickness ◽  
History Of ◽  
The Mean

Aim To assess subclinical atherosclerosis and the role of inflammatory mediators, vascular endothelial cell activation markers and adipocytokines in systemic lupus erythematosus (SLE) in the presence or absence of metabolic syndrome (MetS). Methods We studied 66 premenopausal female SLE patients (20 with MetS) and 28 female healthy controls (HCs) without history of cardiovascular disease (CVD). Subclinical atherosclerosis was screened by measuring carotid intima media thickness (CIMT). Serum levels of high sensitivity C-reactive protein (hs-CRP), tumour necrosis factor α (TNFα), interleukin 6 (IL-6), soluble intercellular adhesion molecule 1 (sICAM-1), soluble E-selectin, leptin and visfatin were measured. Results The mean age of MetS+SLE, MetS- and HC were 38.3 ± 6.7, 32.7 ± 9.3 and 29.9 ± 5.6 years, respectively. The mean disease duration, SLICC (Systemic Lupus International Collaborating Clinics damage index) and Systemic Lupus Erythematosus Disease Activity Index scores were 74.8 ± 54.9 months, 0.16 ± 0.48 and 1.18 ± 1.5, respectively, and were similar between MetS+and MetS- SLE patients. CIMT values were higher in both MetS+ and MetS- SLE patients than HCs ( p < 0.001). sICAM-1 and erythrocyte sedimentation rate levels were higher in both MetS+ and MetS- SLE patients than HCs ( p < 0.001; p = 0.002, p = 0.001). The SLE MetS+ group had higher CIMT values than SLE MetS- (right: p = 0.003; left: p = 0.025). Leptin levels and homeostatic model assessment (HOMA) scores were significantly higher in SLE MetS+ than SLE MetS- ( p = 0.018; p = 0.04). Leptin and CRP levels and body mass index, SLICC and HOMA scores were correlated with CIMT values (right: p = 0.03, p < 0.001, p < 0.001, p = 0.026 and p < 0.001, and left: p = 0.028, p = 0.03, p = 0.003, p = 0.002 and p = 0.025). Conclusions In premenopausal women with SLE without a history of CVD, CIMT values were increased and related to MetS. Leptin was increased in patients with MetS and correlated with CIMT values.

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