Association of interleukin-6 promoter polymorphism with rheumatoid arthritis: a meta-analysis with trial sequential analysis

2021 ◽  
Author(s):  
Ming Shao ◽  
Huimin Xie ◽  
Hui Yang ◽  
Wei Xu ◽  
Yuting Chen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 6 ◽  
Sequential Analysis ◽  
Meta Analysis ◽  
Promoter Polymorphism ◽  
Trial Sequential Analysis

scholarly journals Association between the interleukin (IL)-17A rs2275913 polymorphism and rheumatoid arthritis susceptibility: a meta-analysis and trial sequential analysis

2021 ◽  
Vol 49 (10) ◽  
pp. 030006052110532
Author(s):  
Ping Chen ◽  
Yuhao Li ◽  
Liangliang Li ◽  
Guixin Zhang ◽  
Feng Zhang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Sequential Analysis ◽  
Web Of Science ◽  
Meta Analysis ◽  
Trial Sequential Analysis ◽  
Dominant Model ◽  
Registration Number ◽  
The Relationship ◽  
Allelic Model ◽  
Arthritis Susceptibility

Objective This meta-analysis was conducted to investigate the relationship between the interleukin (IL)-17A rs2275913 polymorphism and rheumatoid arthritis (RA) susceptibility. Methods Eligible studies were retrieved from PubMed, Embase, and Web of Science. The fixed- or random-effects model was used to calculate the pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) on the basis of heterogeneity. Results Overall, 11 studies containing 4019 RA patients and 4137 controls were included in this meta-analysis. The results suggested a significant association between the IL-17A rs2275913 polymorphism and RA susceptibility in the overall population (allelic model A vs. G: OR = 0.89, 95%CI: 0.83–0.95; heterozygote model GA vs. GG: OR = 0.87, 95%CI: 0.78–0.96; homozygote model AA vs. GG: OR = 0.82, 95%CI: 0.71–0.96; dominant model GA + AA vs. GG: OR = 0.86, 95%CI: 0.78–0.94). In the subgroup analyses, the IL-17A rs2275913 polymorphism was significantly associated with RA risk in Europeans (allelic model A vs. G: OR = 0.87, 95%CI: 0.78–0.97; heterozygote model GA vs. GG: OR = 0.79, 95%CI: 0.68–0.93; dominant model GA + AA vs. GG: OR = 0.79, 95%CI: 0.68–0.92), but not in Africans or Americans. Conclusion This study suggests that the IL-17A rs2275913 polymorphism is significantly associated with RA susceptibility in Europeans. INPLASY registration number: INPLASY202170056.

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