Cognitive correlates of negative symptoms in behavioral variant frontotemporal dementia: implications for the frontal lobe syndrome

2013 ◽  
Vol 34 (11) ◽  
pp. 1893-1896 ◽  
Author(s):  
Michele Poletti ◽  
Claudio Lucetti ◽  
Chiara Logi ◽  
Filippo Baldacci ◽  
Gabriele Cipriani ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Frontal Lobe ◽  
Negative Symptoms ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Cognitive Correlates ◽  
Frontal Lobe Syndrome

Impact of Imaging and Cerebrospinal Fluid Biomarkers on Behavioral Variant Frontotemporal Dementia Diagnosis within a Late-Onset Frontal Lobe Syndrome Cohort

2015 ◽  
Vol 41 (1-2) ◽  
pp. 16-26 ◽  
Author(s):  
Welmoed A. Krudop ◽  
Annemiek Dols ◽  
Cora J. Kerssens ◽  
Niels D. Prins ◽  
Christiane Möller ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Frontotemporal Dementia ◽  
Frontal Lobe ◽  
Fdg Pet ◽  
Late Onset ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Diagnostic Certainty ◽  
18F Fdg ◽  
Frontal Lobe Syndrome ◽  
The Impact

Background: The criteria for behavioral variant frontotemporal dementia (bvFTD) incorporate MRI and [18F]-FDG-PET. Cerebrospinal fluid (CSF) analysis is merely advised for excluding Alzheimer's disease. Aims: We aimed to assess the impact of biomarkers on diagnostic certainty and contingent changes of bvFTD diagnosis within the clinically relevant neuropsychiatric differential diagnosis of subjects with a late-onset frontal lobe syndrome (LOF). Methods: We included 137 patients with LOF, aged 45-75 years, 72% males. Biomarker disclosure was considered contributing after any substantial difference in diagnostic certainty or a diagnostic change. Percentages of contributing biomarkers were compared between three major diagnostic groups (bvFTD, psychiatry, other neurological disorders). Certainty levels in stable diagnostic groups were compared to those with a diagnostic change. Results: Biomarkers contributed in 53, 60 and 41% of the LOF patients for MRI, [18F]-FDG-PET and CSF, respectively. Biomarkers changed the diagnosis in 14% of cases towards bvFTD and in 13% from bvFTD into an alternative. Those that changed had a lower level of a priori diagnostic certainty compared to stable diagnoses. Conclusion: Our study not only supports the widely accepted use of MRI and [18F]-FDG-PET in diagnosing or excluding bvFTD, but also shows that CSF biomarkers aid clinicians in the diagnostic process.

O2-14-04: IDENTIFYING BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA AMONG PATIENTS WITH A LATE-ONSET FRONTAL LOBE SYNDROME: SUMMARY RESULTS OF THE LOF STUDY

2006 ◽  
Vol 14 (7S_Part_12) ◽  
pp. P657-P658
Author(s):  
Yolande A.L. Pijnenburg ◽  
Everard Vijverberg ◽  
Welmoed A. Krudop ◽  
Flora T. Gossink ◽  
Niels D. Prins ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Frontal Lobe ◽  
Late Onset ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Frontal Lobe Syndrome

scholarly journals Diagnostic Accuracy of the Frontotemporal Dementia Consensus Criteria in the Late-Onset Frontal Lobe Syndrome

2016 ◽  
Vol 41 (3-4) ◽  
pp. 210-219 ◽  
Author(s):  
Everard G.B. Vijverberg ◽  
Annemiek Dols ◽  
Welmoed A. Krudop ◽  
Anne Peters ◽  
Cora J. Kerssens ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Psychiatric Disorders ◽  
Frontotemporal Dementia ◽  
Frontal Lobe ◽  
Late Onset ◽  
Diagnostic Process ◽  
International Consensus ◽  
Good Diagnostic Accuracy ◽  
Frontal Lobe Syndrome

Background/Aims: We aimed to prospectively assess the diagnostic accuracy of the revised criteria for behavioural variant frontotemporal dementia (bvFTD) among subjects presenting with a frontal lobe syndrome in middle-late adulthood. Methods: Patients were included based on a predominant behavioural clinical presentation, a Frontal Behavioural Inventory (FBI) score of ≥11 and/or a Stereotypy Rating Inventory (SRI) score of ≥10. At baseline, the fulfilment of the international consensus criteria for behavioural variant FTD (FTDC) was systematically recorded. The 2-year follow-up consensus diagnosis was used as the gold standard to calculate sensitivity and specificity of the FTDC criteria for possible and probable bvFTD. Results: Two-year follow-up data were available for 116 patients (85%). Two-year follow-up consensus diagnoses consisted of probable/definite bvFTD (n = 27), other dementia (n = 30), psychiatric disorders (n = 46) and other neurological disorders (n = 13). Sensitivity for possible bvFTD was 85% (95% CI 70-95%) at a specificity of 27% (95% CI 19-37%). Sensitivity for probable bvFTD was 85% (95% CI 69-95%), whereas their specificity was 82% (95% CI 73-89%). Conclusions: We found a good diagnostic accuracy for FTDC probable bvFTD. However, the specificity for FTDC possible bvFTD was low. Our results reflect the symptomatic overlap between bvFTD, other neurological conditions and psychiatric disorders, and the relevance of adding neuroimaging to the diagnostic process.

Diogenes Syndrome in Frontotemporal Dementia

2017 ◽  
Vol 32 (7) ◽  
pp. 438-443 ◽  
Author(s):  
Catherine M. Finney ◽  
Mario F. Mendez
Keyword(s):  
Frontotemporal Dementia ◽  
Frontal Lobe ◽  
Treatment Options ◽  
Self Care ◽  
Self Awareness ◽  
Potential Treatment ◽  
Review Of The Literature ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Diogenes Syndrome ◽  
Striatal System

Diogenes syndrome refers to the combination of extreme self-neglect and excessive collecting with clutter and squalor, which is often present in patients with dementia. Diogenes syndrome may be particularly common in behavioral variant frontotemporal dementia (bvFTD), and the investigation of these patients may help clarify the nature of this syndrome. We describe 5 patients with bvFTD who exhibited a decline in self-care accompanied by hoarding behaviors. These patients, and a review of the literature, suggest a combination of frontal lobe disturbances: loss of insight or self-awareness with a failure to clean up or discard, a general compulsive drive, and an innate impulse to take environmental items. This impulse may be part of the environmental dependency syndrome in frontal disease, with specific involvement of a right frontolimbic–striatal system. Further investigation of the similarities and mechanisms of these symptoms in bvFTD could help in understanding Diogenes syndrome and lead to potential treatment options.

Sign in / Sign up

Export Citation Format

Share Document