Increased complexin-1 and decreased miR-185 expression levels in Behçet’s disease with and without neurological involvement

2015 ◽  
Vol 37 (3) ◽  
pp. 411-416 ◽  
Author(s):  
Elif Uğurel ◽  
Elçin Şehitoğlu ◽  
Erdem Tüzün ◽  
Murat Kürtüncü ◽  
Arzu Çoban ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Behcet's Disease ◽  
Expression Levels

VEGF and mRNA VEGF expression in CSF from Behçet's disease with neurological involvement

2009 ◽  
Vol 213 (1-2) ◽  
pp. 148-153 ◽  
Author(s):  
Kamel Hamzaoui ◽  
Khaled Ayed ◽  
M'Hamed Hamza ◽  
Agnès Hamzaoui
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Vegf Expression ◽  
Behcet's Disease

scholarly journals Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients

Brain ◽  
1999 ◽  
Vol 122 (11) ◽  
pp. 2171-2182 ◽  
Author(s):  
Gülsen Akman-Demir ◽  
Piraye Serdaroglu ◽  
Banu Tasçi
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Behcet's Disease ◽  
Clinical Patterns

scholarly journals Pattern recognition is a sequential process—accurate diagnosis and treatment 20 years after presentation

2019 ◽  
Vol 2019 (7) ◽  
Author(s):  
Dimos Merinopoulos ◽  
Janak Saada ◽  
Colin Jones ◽  
Chetan Mukhtyar
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
White Matter Lesions ◽  
Neurological Involvement ◽  
Neurological Manifestations ◽  
Visual Aura ◽  
Behcet's Disease ◽  
Ocular Manifestations ◽  
Retinal Haemorrhages

Abstract A 25-year-old woman presented with ophthalmic and neurological manifestations. Her ocular manifestations included bilateral uveitis, multifocal retinal phlebitis, vitreitis and multiple retinal haemorrhages. Her neurological manifestations included migrainous headaches with visual aura, transient sensory symptoms and posterior circulation Transient Ischemic Attack (TIA). Magnetic resonance imaging of the brain demonstrated lesions that involved the deep white matter lesions initially and progressed to also involve the juxta cortical white and deep grey matter and brain stem, but without further neurological manifestations. She was sequentially treated with intravenous and oral glucocorticoid, cyclophosphamide and mycophenolate mofetil, but she continued to suffer with persistent episodes of retinal haemorrhages. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), Susac syndrome and Behcet’s disease were considered in the differential diagnosis. Genetic workup and clinical picture were not suggestive of the former two. Further history of oro-genital ulceration in younger age emerged, which pointed strongly towards a diagnosis of Behcet’s disease with neurological involvement. She was treated with infliximab and methotrexate with complete resolution of her symptoms and withdrawal of corticosteroids for the first time in over two decades.

Clinical features and disease course of neurological involvement in Behcet's disease: HUVAC experience

2020 ◽  
Vol 38 ◽  
pp. 101512 ◽  
Author(s):  
Ertugrul Cagri Bolek ◽  
Alper Sari ◽  
Levent Kilic ◽  
Umut Kalyoncu ◽  
Asli Kurne ◽  
...  
Keyword(s):  
Clinical Features ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Disease Course ◽  
Behcet's Disease

scholarly journals The Clinical Features and Risk Factors of Parenchymal Neuro-Behcet’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Dong Yan ◽  
JinJing Liu ◽  
Yuehua Zhang ◽  
Wei Yuan ◽  
Yan Xu ◽  
...  
Keyword(s):  
Clinical Features ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Biological Agents ◽  
Neurological Involvement ◽  
Cervical Cord ◽  
Ocular Involvement ◽  
College Hospital ◽  
Behcet's Disease

To investigate the clinical features of parenchymal neuro-Behcet’s disease (p-NBD), we retrospectively reviewed the medical records of 1009 BD patients admitted to Peking Union Medical College Hospital from 2000 to 2016. Forty-two patients (25 males and 17 females) with p-NBD and eighty-four age- and sex-matched BD patients without neurological involvement who were served as controls were enrolled. Neurological onset was concomitant with the onset of BD in six cases (14.3%). Pyramidal signs (50.0%) and headache (33.3%) were the most common manifestations. On MRI, the lesions were mainly in the midline structures and hyperintense in the T2-weighted image. The most common lesion was the brainstem (54.8%). Spinal cord involvement was observed in five cases, four of which with cervical cord involvement. Multifocal lesions were observed in 13 patients. Ocular involvement was more prevalent in p-NBD (35.7%) (P=0.041, OR=2.36, 95% CI=1.03-5.44) compared with controls. All patients received corticosteroids and immunosuppressants, mainly cyclophosphamide (39/42). Six patients with severe/refractory condition received biological agents and achieved response measured by decreased Rankin score (P=0.002). With a median follow-up of 28 months, 22 patients (61.1%) achieved clinical improvements, while 10 (27.8%) relapsed and 4 died (mortality rate 11.1%). p-NBD is a rare yet disabling and life-threatening complication of BD. Ocular involvement is a risk factor for p-NBD. Promptly aggressive treatment is essential for improving prognosis, and biological agents might be a promising approach for severe/refractory p-NBD.

Cognitive impairment in Behçet's disease patients without overt neurological involvement

2004 ◽  
Vol 220 (1-2) ◽  
pp. 99-104 ◽  
Author(s):  
Roberto Monastero ◽  
Cecilia Camarda ◽  
Carmela Pipia ◽  
Gianluca Lopez ◽  
Lawrence K.C Camarda ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Behcet's Disease

scholarly journals mRNA Expression Levels of NKp30, NKp46, NKG2D, Perforin and Granzyme in the Behçet’s Disease

2021 ◽  
Author(s):  
Metin Yusuf Gelmez ◽  
Suzan Çınar ◽  
Esin Aktaş ◽  
Fatma Betül Öktelik ◽  
Goncagul Babuna-kobaner ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Expression Levels ◽  
Mrna Expression Levels

scholarly journals Olfactory functions in Behçet’s disease: A review

2018 ◽  
Vol 8 (32) ◽  
pp. 213-217
Author(s):  
Nuray Bayar Muluk
Keyword(s):  
Behçet’S Disease ◽  
Bacterial Infections ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Olfactory Dysfunction ◽  
Neurological Involvement ◽  
Behcet's Disease ◽  
Nasal Cartilage ◽  
Mucosal Involvement

Abstract OBJECTIVES. We reviewed the relationship between olfactory functions and Behçet’s disease (BD). MATERIAL AND METHODS. We searched Pubmed, Google, Google Scholar and Proquest Cebtral Database with the key words of “olfactory”, “functions”, “smell”, “nasal” and “Behçet’s disease”. RESULTS. Behçet’s disease influences the nasal mucosa. Nasal mucosal inclusion causes mucosal ulcers, pain, burning, nasal obstruction, epistaxis, nasal itching and dysosmia. Nasal cartilage deformity is also reported. The higher rate of comorbid chronic rhinosinusitis (CRS) in BD patients may likewise be because of the complex mechanism of the disease inclining the host tissues to bacterial infections. Olfactory functions may decrease in BD. Odor identification may be lower in patients BD. CONCLUSION. An olfactory dysfunction may be seen in patients with BD. BD patients should be evaluated for the involvement of the olfactory function and may require treatment because of a malfunction of the olfactory system that influences the quality of life. Neurological involvement associated with BD might play a more important role in causing olfactory dysfunction than mucosal involvement.

Neurological Involvement in Paediatric Behçet's Disease

2010 ◽  
Vol 41 (05) ◽  
pp. 228-234 ◽  
Author(s):  
J. Metreau-Vastel ◽  
Y. Mikaeloff ◽  
M. Tardieu ◽  
I. Koné-Paut ◽  
T.-A. Tran
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Neurological Involvement ◽  
Behcet's Disease
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