A treatable case of autoimmune GFAP astrocytopathy presenting chronic progressive cognitive impairment

Pre-Kraepelinian observations converged in Kahlbaum’s and Hecker’s description of Hebephrenia. For Kraepelin, Hebephrenia was an ‘idiopathic incurable dementia whose onset is in adolescence’. It became the core of ‘Dementia Praecox’, and then Bleulerian ‘Schizophrenia’. In recent decades, the resurgence of the ‘late neurodevelopment’ hypothesis of schizophrenia has brought into focus Hecker’s clinical reports of adolescents who, as a result of a putative loss of psychic energy, showed a rapidly progressive cognitive impairment leading to functional and behavioural disorganization. This paper summarizes the nineteenth-century conceptualization of Hebephrenia as a developmental illness.

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The utility of questionnaires in cognitive and functional assessment in Alzheimer's disease

International Psychogeriatrics ◽

10.1017/s1041610210001559 ◽

2010 ◽

Vol 23 (2) ◽

pp. 333-334

Author(s):

V M Aziz ◽

J. Yagoub ◽

K. Saba ◽

M. Asaad

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Functional Assessment ◽

Clinical Picture ◽

Behavioral Changes ◽

Cognitive Domains ◽

Amnesic Syndrome ◽

Insidious Onset ◽

Progressive Cognitive Impairment

Alzheimer's disease (AD) manifests clinically with an insidious onset and slow but progressive cognitive impairment. The clinical picture of AD can be classified into cognitive and behavioral changes. The initial deficit usually manifests as an amnesic syndrome which may progress very gradually for several years before impairment in other cognitive domains, such as language, semantic memory and visuospatial function, becomes apparent (Hodges and Patterson, 1995).

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Rapidly progressive cognitive impairment in a patient with high flow dural arteriovenous fistulas, cerebral sinus thrombosis and protein S deficiency

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2013.12.025 ◽

2014 ◽

Vol 21 (9) ◽

pp. 1654-1656 ◽

Cited By ~ 5

Author(s):

M. Pasi ◽

S. Nappini ◽

E. Salvadori ◽

S. Mangiafico ◽

N. Limbucci ◽

...

Keyword(s):

Cognitive Impairment ◽

Sinus Thrombosis ◽

Protein S ◽

High Flow ◽

Protein S Deficiency ◽

Arteriovenous Fistulas ◽

S Deficiency ◽

Dural Arteriovenous Fistulas ◽

Cerebral Sinus ◽

Progressive Cognitive Impairment

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Role of Vascular Disease in Alzheimer-Like Progressive Cognitive Impairment

Stroke ◽

10.1161/strokeaha.115.009010 ◽

2016 ◽

Vol 47 (2) ◽

pp. 577-580 ◽

Cited By ~ 6

Author(s):

Anand Viswanathan ◽

Steven M. Greenberg ◽

Philip Scheltens

Keyword(s):

Cognitive Impairment ◽

Vascular Disease ◽

Progressive Cognitive Impairment

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Arterio-inferior Sagittal Sinus Fistulae: Case Report

Neurosurgery ◽

10.1227/00006123-198912000-00021 ◽

1989 ◽

Vol 25 (6) ◽

pp. 971-975 ◽

Cited By ~ 8

Author(s):

Michael K. Morgan ◽

Thoralf M. Sundt ◽

Wayne O. Houser

Keyword(s):

Cognitive Impairment ◽

Case Report ◽

Arteriovenous Malformation ◽

Vein Of Galen ◽

Arteriovenous Fistulae ◽

Postoperative Course ◽

Hyperperfusion Syndrome ◽

Sagittal Sinus ◽

Progressive Cognitive Impairment ◽

Satisfactory Recovery

Abstract The management of the case of a 9-year-old boy with progressive cognitive impairment due to arteriovenous fistulae at the apex of the inferior sagittal sinus is reported. This represents a unique location for an extraparenchymal deep central arteriovenous malformation. The patient underwent staged ablation of the lesion by surgery. The postoperative course was complicated by expansion of an aneurysmal vein of Galen undergoing thrombosis and hyperperfusion syndrome, but the patient ultimately made a satisfactory recovery.

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