scholarly journals Correction to: Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes

2021 ◽  
Author(s):  
Cornelia Brendle ◽  
Uwe Klose ◽  
Johann-Martin Hempel ◽  
Jens Schittenhelm ◽  
Marco Skardelly ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Diagnosis ◽  
Dynamic Susceptibility ◽  
Resonance Imaging ◽  
Link Type ◽  
Initial Tumor

A Correction to this paper has been published: https://doi.org/10.1007/s10072-021-05352-6

scholarly journals Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes

2020 ◽  
Vol 41 (12) ◽  
pp. 3625-3632 ◽  
Author(s):  
Cornelia Brendle ◽  
Uwe Klose ◽  
Johann-Martin Hempel ◽  
Jens Schittenhelm ◽  
Marco Skardelly ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Diagnosis ◽  
Dynamic Susceptibility ◽  
Resonance Imaging ◽  
Initial Tumor

scholarly journals Anisotropic cerebral vascular architecture causes orientation dependency in cerebral blood flow and volume measured with dynamic susceptibility contrast magnetic resonance imaging

2016 ◽  
Vol 37 (3) ◽  
pp. 1108-1119 ◽  
Author(s):  
Enedino Hernández-Torres ◽  
Nora Kassner ◽  
Nils Daniel Forkert ◽  
Luxi Wei ◽  
Vanessa Wiggermann ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Dynamic Susceptibility ◽  
Resonance Imaging ◽  
Dynamic Susceptibility Contrast ◽  
Contrast Magnetic Resonance Imaging ◽  
Contrast Magnetic Resonance ◽  
Tissue Orientation ◽  
Susceptibility Contrast

Measurements of cerebral perfusion using dynamic susceptibility contrast magnetic resonance imaging rely on the assumption of isotropic vascular architecture. However, a considerable fraction of vessels runs in parallel with white matter tracts. Here, we investigate the effects of tissue orientation on dynamic susceptibility contrast magnetic resonance imaging. Tissue orientation was measured using diffusion tensor imaging and dynamic susceptibility contrast was performed with gradient echo planar imaging. Perfusion parameters and the raw dynamic susceptibility contrast signals were correlated with tissue orientation. Additionally, numerical simulations were performed for a range of vascular volumes of both the isotropic vascular bed and anisotropic vessel components, as well as for a range of contrast agent concentrations. The effect of the contrast agent was much larger in white matter tissue perpendicular to the main magnetic field compared to white matter parallel to the main magnetic field. In addition, cerebral blood flow and cerebral blood volume were affected in the same way with angle-dependent variations of up to 130%. Mean transit time and time to maximum of the residual curve exhibited weak orientation dependency of 10%. Numerical simulations agreed with the measured data, showing that one-third of the white matter vascular volume is comprised of vessels running in parallel with the fibre tracts.

scholarly journals Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults

2018 ◽  
Vol 13 (4) ◽  
pp. 596-603 ◽  
Author(s):  
Mirela Dobre ◽  
Sarah A. Gaussoin ◽  
Jeffrey T. Bates ◽  
Michel B. Chonchol ◽  
Debbie L. Cohen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Executive Function ◽  
Metabolic Acidosis ◽  
Cognitive Function ◽  
Magnetic Resonance ◽  
Bicarbonate Level ◽  
Serum Bicarbonate ◽  
Resonance Imaging ◽  
Bicarbonate Concentration ◽  
Link Type

Background and objectivesCognitive function worsens as kidney function declines, but mechanisms contributing to this association are not completely understood. Metabolic acidosis, a common complication of CKD, leads to neural networks overexcitation and is involved in cerebral autoregulation. We aimed to evaluate the association between serum bicarbonate concentration as a measure of metabolic acidosis, and cognitive function in hypertensive adults with and without CKD.Design, setting, participants, & measurementsFive cognitive summary scores were measured (global cognitive function, executive function, memory, attention/concentration, and language) in 2853 participants in the Systolic BP Intervention Trial (SPRINT). Multivariable linear regression models adjusted for demographics, comorbidities, systolic BP, medications, eGFR and albuminuria evaluated the cross-sectional association between bicarbonate and cognition at SPRINT baseline. In a subset (n=681) who underwent brain magnetic resonance imaging, the models were adjusted for white matter hyperintensity volume, vascular reactivity, and cerebral blood flow.ResultsThe mean age (SD) was 68 (8.5) years. Global cognitive and executive functions were positively associated with serum bicarbonate (estimate [SEM]: 0.014 [0.006]; P=0.01, and 0.018 [0.006]; P=0.003, respectively). Each 1 mEq/L lower bicarbonate level had a similar association with global cognitive and executive function as being 4.3 and 5.4 months older, respectively. The association with global cognition persisted after magnetic resonance imaging findings adjustment (estimate [SEM]: 0.03 [0.01]; P=0.01). There was no association between serum bicarbonate level and memory, attention/concentration, and language.ConclusionsIn a large cohort of hypertensive adults, higher serum bicarbonate levels were independently associated with better global cognitive and executive performance. (ClinicalTrials.gov: NCT01206062).

scholarly journals Neuroplasticity induced by general anaesthesia: study protocol for a randomised cross-over clinical trial exploring the effects of sevoflurane and propofol on the brain – A 3-T magnetic resonance imaging study of healthy volunteers

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Signe Sloth Madsen ◽  
Kirsten Møller ◽  
Karsten Skovgaard Olsen ◽  
Mark Bitsch Vestergaard ◽  
Ulrich Lindberg ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Trial ◽  
Cognitive Function ◽  
Magnetic Resonance ◽  
Healthy Volunteers ◽  
General Anaesthesia ◽  
Well Being ◽  
Resonance Imaging ◽  
Link Type ◽  
The Brain

Abstract Background Although used extensively worldwide, the effects of general anaesthesia on the human brain remain largely elusive. Moreover, general anaesthesia may contribute to serious conditions or adverse events such as postoperative cognitive dysfunction and delirium. To understand the basic mechanisms of general anaesthesia, this project aims to study and compare possible de novo neuroplastic changes induced by two commonly used types of general anaesthesia, i.e. inhalation anaesthesia by sevoflurane and intravenously administered anaesthesia by propofol. In addition, we wish to to explore possible associations between neuroplastic changes, neuropsychological adverse effects and subjective changes in fatigue and well-being. Methods This is a randomised, participant- and assessor-blinded, cross-over clinical trial. Thirty healthy volunteers (male:female ratio 1:1) will be randomised to general anaesthesia by either sevoflurane or propofol. Multimodal magnetic resonance imaging (MRI) of the brain will be performed before and after general anaesthesia and repeated after 1 and 8 days. Each magnetic resonance imaging session will be accompanied by cognitive testing and questionnaires on fatigue and well-being. After a wash-out period of 4 weeks, the volunteers will receive the other type of anaesthetic (sevoflurane or propofol), followed by the same series of tests. Primary outcomes: changes in T1-weighted 3D anatomy and diffusion tensor imaging. Secondary outcomes: changes in resting-state functional magnetic resonance imaging, fatigue, well-being, cognitive function, correlations between magnetic resonance imaging findings and the clinical outcomes (questionnaires and cognitive function). Exploratory outcomes: changes in cerebral perfusion and oxygen metabolism, lactate, and response to visual stimuli. Discussion To the best of our knowledge, this is the most extensive and advanced series of studies with head-to-head comparison of two widely used methods for general anaesthesia. Recruitment was initiated in September 2019. Trial registration Approved by the Research Ethics Committee in the Capital Region of Denmark, ref. H-18028925 (6 September 2018). EudraCT and Danish Medicines Agency: 2018-001252-35 (23 March 2018). www.clinicaltrials.gov, ID: NCT04125121. Retrospectively registered on 10 October 2019.

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