The preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes

2019 ◽  
Vol 23 (2) ◽  
pp. 161-170 ◽  
Author(s):  
Ruoqiong Cao ◽  
Hicret Islamoglu ◽  
Garrett Teskey ◽  
Karo Gyurjian ◽  
Rachel Abrahem ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Immune Responses ◽  
Healthy Subjects ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection

scholarly journals Type 2 Diabetes Mellitus

2019 ◽  
Author(s):  
Vishwanath Venketaraman ◽  
Aram Yegiazaryan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mycobacterium Tuberculosis ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Altered Metabolism

Uncontrolled Type 2 diabetes is associated with altered metabolism resulting in microvascular and macrovascular diseases and enhanced susceptibility to Mycobacterium tuberculosis infection.

scholarly journals Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and non-diabetic mice

2020 ◽  
Author(s):  
Harindra D. Sathkumara ◽  
Karyna Hansen ◽  
Socorro Miranda-Hernandez ◽  
Brenda Govan ◽  
Catherine M. Rush ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Disease Burden ◽  
Low Dose ◽  
Tuberculosis Infection ◽  
Diabetic Mice ◽  
Mycobacterium Tuberculosis Infection ◽  
Therapeutic Concentration ◽  
Global Control

AbstractComorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here we assessed the efficacy of metformin (MET); an anti-diabetic drug, in mice infected with a very-low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected non-diabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and non-diabetic individuals.

Immunological response to Mycobacterium tuberculosis infection in blood from type 2 diabetes patients

2017 ◽  
Vol 186 ◽  
pp. 41-45 ◽  
Author(s):  
Sara Raposo-García ◽  
José Manuel Guerra-Laso ◽  
Silvia García-García ◽  
Javier Juan-García ◽  
Eduardo López-Fidalgo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Immunological Response ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Diabetes Patients

Increased susceptibility to Mycobacterium tuberculosis infection in a diet-induced murine model of type 2 diabetes

2020 ◽  
Vol 22 (8) ◽  
pp. 303-311 ◽  
Author(s):  
Mohammad Abdul Alim ◽  
Andreas Kupz ◽  
Suchandan Sikder ◽  
Catherine Rush ◽  
Brenda Govan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Murine Model ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Increased Susceptibility

scholarly journals Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

2020 ◽  
Vol 65 (1) ◽  
pp. e01422-20
Author(s):  
Harindra D. Sathkumara ◽  
Karyna Hansen ◽  
Socorro Miranda-Hernandez ◽  
Brenda Govan ◽  
Catherine M. Rush ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Disease Burden ◽  
Low Dose ◽  
Diabetic Mice ◽  
Antidiabetic Drug ◽  
Mycobacterium Tuberculosis Infection ◽  
Therapeutic Concentration ◽  
Content Type

ABSTRACTComorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.

scholarly journals The impact of HIV exposure and maternal Mycobacterium tuberculosis infection on infant immune responses to bacille Calmette-Guérin vaccination

AIDS ◽  
2015 ◽  
Vol 29 (2) ◽  
pp. 155-165 ◽  
Author(s):  
Christine E. Jones ◽  
Anneke C. Hesseling ◽  
Nontobeko G. Tena-Coki ◽  
Thomas J. Scriba ◽  
Novel N. Chegou ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Immune Responses ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Bacille Calmette Guerin ◽  
Hiv Exposure ◽  
The Impact

scholarly journals Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity

Cell Reports ◽  
2019 ◽  
Vol 27 (9) ◽  
pp. 2649-2664.e5 ◽  
Author(s):  
Sulayman Benmerzoug ◽  
Badreddine Bounab ◽  
Stéphanie Rose ◽  
David Gosset ◽  
Franck Biet ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Lung Inflammation ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Type 2 Immunity ◽  
Dependent Type
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