scholarly journals Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and non-diabetic mice

2020 ◽  
Author(s):  
Harindra D. Sathkumara ◽  
Karyna Hansen ◽  
Socorro Miranda-Hernandez ◽  
Brenda Govan ◽  
Catherine M. Rush ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Disease Burden ◽  
Low Dose ◽  
Tuberculosis Infection ◽  
Diabetic Mice ◽  
Mycobacterium Tuberculosis Infection ◽  
Therapeutic Concentration ◽  
Global Control

AbstractComorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here we assessed the efficacy of metformin (MET); an anti-diabetic drug, in mice infected with a very-low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected non-diabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and non-diabetic individuals.

scholarly journals Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

2020 ◽  
Vol 65 (1) ◽  
pp. e01422-20
Author(s):  
Harindra D. Sathkumara ◽  
Karyna Hansen ◽  
Socorro Miranda-Hernandez ◽  
Brenda Govan ◽  
Catherine M. Rush ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Disease Burden ◽  
Low Dose ◽  
Diabetic Mice ◽  
Antidiabetic Drug ◽  
Mycobacterium Tuberculosis Infection ◽  
Therapeutic Concentration ◽  
Content Type

ABSTRACTComorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.

scholarly journals Type 2 Diabetes Mellitus

2019 ◽  
Author(s):  
Vishwanath Venketaraman ◽  
Aram Yegiazaryan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mycobacterium Tuberculosis ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Altered Metabolism

Uncontrolled Type 2 diabetes is associated with altered metabolism resulting in microvascular and macrovascular diseases and enhanced susceptibility to Mycobacterium tuberculosis infection.

Immunological response to Mycobacterium tuberculosis infection in blood from type 2 diabetes patients

2017 ◽  
Vol 186 ◽  
pp. 41-45 ◽  
Author(s):  
Sara Raposo-García ◽  
José Manuel Guerra-Laso ◽  
Silvia García-García ◽  
Javier Juan-García ◽  
Eduardo López-Fidalgo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Immunological Response ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Diabetes Patients

Increased susceptibility to Mycobacterium tuberculosis infection in a diet-induced murine model of type 2 diabetes

2020 ◽  
Vol 22 (8) ◽  
pp. 303-311 ◽  
Author(s):  
Mohammad Abdul Alim ◽  
Andreas Kupz ◽  
Suchandan Sikder ◽  
Catherine Rush ◽  
Brenda Govan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Murine Model ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Increased Susceptibility

scholarly journals Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity

Cell Reports ◽  
2019 ◽  
Vol 27 (9) ◽  
pp. 2649-2664.e5 ◽  
Author(s):  
Sulayman Benmerzoug ◽  
Badreddine Bounab ◽  
Stéphanie Rose ◽  
David Gosset ◽  
Franck Biet ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Lung Inflammation ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Type 2 Immunity ◽  
Dependent Type

GPR183 regulates interferons and bacterial growth during Mycobacterium tuberculosis infection: interaction with type 2 diabetes and TB disease severity

2020 ◽  
Author(s):  
Stacey Bartlett ◽  
Adrian Tandhyka Gemiarto ◽  
Minh Dao Ngo ◽  
Haressh Sajiir ◽  
Semira Hailu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Disease Severity ◽  
Mycobacterial Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Important Regulator ◽  
Chest X Ray ◽  
Mycobacterial Growth

AbstractOxidized cholesterols have emerged as important signaling molecules of immune function, but little is known about the role of these oxysterols during mycobacterial infections. We found that expression of the oxysterol-receptor GPR183 was reduced in blood from patients with tuberculosis (TB) and type 2 diabetes (T2D) compared to TB patients without T2D and was associated with TB disease severity on chest x-ray. GPR183 activation by 7α,25-hydroxycholesterol (7α,25-OHC) reduced growth of Mycobacterium tuberculosis (Mtb) and Mycobacterium bovis BCG in primary human monocytes, an effect abrogated by the GPR183 antagonist GSK682753. Growth inhibition was associated with reduced IFN-β and IL-10 expression and enhanced autophagy. Mice lacking GPR183 had significantly increased lung Mtb burden and dysregulated IFNs during early infection. Together, our data demonstrate that GPR183 is an important regulator of intracellular mycobacterial growth and interferons during mycobacterial infection.Graphical Abstract

scholarly journals Pulmonary Lymphatics Are Primary Sites of Mycobacterium tuberculosis Infection in Guinea Pigs Infected by Aerosol

2006 ◽  
Vol 74 (9) ◽  
pp. 5397-5401 ◽  
Author(s):  
Randall J. Basaraba ◽  
Erin E. Smith ◽  
Crystal A. Shanley ◽  
Ian M. Orme
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Lymph Nodes ◽  
Guinea Pigs ◽  
Low Dose ◽  
Latent Infection ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Regional Lymph Nodes

ABSTRACT Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.

Sign in / Sign up

Export Citation Format

Share Document