Risk factors for metachronous colorectal cancer in Lynch syndrome patients: a registry-based observational mono-institutional study cohort

2020 ◽  
Vol 25 (9) ◽  
pp. 1644-1652
Author(s):  
Stefano Signoroni ◽  
Guglielmo Niccolò Piozzi ◽  
Maria Teresa Ricci ◽  
Andrea Mancini ◽  
Alberto Morabito ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Lynch Syndrome ◽  
Study Cohort ◽  
Metachronous Colorectal Cancer

scholarly journals Feasibility of Screening for Lynch Syndrome Among Patients With Colorectal Cancer

2008 ◽  
Vol 26 (35) ◽  
pp. 5783-5788 ◽  
Author(s):  
Heather Hampel ◽  
Wendy L. Frankel ◽  
Edward Martin ◽  
Mark Arnold ◽  
Karamjit Khanduja ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Mismatch Repair ◽  
Cancer Surveillance ◽  
Study Cohort ◽  
Entire Study ◽  
Gene Testing ◽  
Revised Bethesda Guidelines ◽  
Repair Genes ◽  
Entire Study Cohort

Purpose Identifying individuals with Lynch syndrome (LS) is highly beneficial. However, it is unclear whether microsatellite instability (MSI) or immunohistochemistry (IHC) should be used as the screening test and whether screening should target all patients with colorectal cancer (CRC) or those in high-risk subgroups. Patients and Methods MSI testing and IHC for the four mismatch repair proteins was performed on 500 tumors from unselected patients with CRC. If either MSI or IHC was abnormal, complete mutation analysis for the mismatch repair genes was performed. Results Among the 500 patients, 18 patients (3.6%) had LS. All 18 patients detected with LS (100%) had MSI-high tumors; 17 (94%) of 18 patients with LS were correctly predicted by IHC. Of the 18 probands, only eight patients (44%) were diagnosed at age younger than 50 years, and only 13 patients (72%) met the revised Bethesda guidelines. When these results were added to data on 1,066 previously studied patients, the entire study cohort (N = 1,566) showed an overall prevalence of 44 of 1,566 patients (2.8%; 95% CI, 2.1% to 3.8%) for LS. For each proband, on average, three additional family members carried MMR mutations. Conclusion One of every 35 patients with CRC has LS, and each has at least three relatives with LS; all of whom can benefit from increased cancer surveillance. For screening, IHC is almost equally sensitive as MSI, but IHC is more readily available and helps to direct gene testing. Limiting tumor analysis to patients who fulfill Bethesda criteria would fail to identify 28% (or one in four) cases of LS.

Risk factors for metachronous colorectal cancer or polyp: A systematic review and meta-analysis

2017 ◽  
Vol 32 (2) ◽  
pp. 301-326 ◽  
Author(s):  
Harindra Jayasekara ◽  
Jeanette C Reece ◽  
Daniel D Buchanan ◽  
Dennis J Ahnen ◽  
Susan Parry ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Systematic Review ◽  
Meta Analysis ◽  
Metachronous Colorectal Cancer

Risk of metachronous colorectal cancer following colectomy in Lynch syndrome: a systematic review and meta-analysis

2017 ◽  
Vol 19 (6) ◽  
pp. 528-536 ◽  
Author(s):  
C. C. Anele ◽  
S. O. Adegbola ◽  
A. Askari ◽  
A. Rajendran ◽  
S. K. Clark ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Lynch Syndrome ◽  
Meta Analysis ◽  
Metachronous Colorectal Cancer

The Incidence and Risk Factors of Metachronous Colorectal Cancer

2012 ◽  
Vol 55 (5) ◽  
pp. 522-531 ◽  
Author(s):  
Sanna A. Mulder ◽  
Ries Kranse ◽  
Ronald A. Damhuis ◽  
Rob J. Th. Ouwendijk ◽  
Ernst J. Kuipers ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Metachronous Colorectal Cancer

Survival Outcome and Risk of Metachronous Colorectal Cancer After Surgery in Lynch Syndrome

2016 ◽  
Vol 24 (4) ◽  
pp. 1085-1092 ◽  
Author(s):  
Tae Jun Kim ◽  
Eun Ran Kim ◽  
Sung Noh Hong ◽  
Young-Ho Kim ◽  
Jung Wook Huh ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Survival Outcome ◽  
Metachronous Colorectal Cancer

Metachronous colorectal cancer risk in Lynch syndrome patients—should the endoscopic surveillance be more intensive?

2018 ◽  
Vol 33 (6) ◽  
pp. 703-708 ◽  
Author(s):  
Morgan Anyla ◽  
Jérémie H. Lefevre ◽  
Ben Creavin ◽  
Chrystelle Colas ◽  
Magali Svrcek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Lynch Syndrome ◽  
Colorectal Cancer Risk ◽  
Endoscopic Surveillance ◽  
Metachronous Colorectal Cancer

scholarly journals A predictive model of metachronous colorectal cancer occurrence in Lynch syndrome

2010 ◽  
Vol 8 (Suppl 1) ◽  
pp. O7
Author(s):  
Lucio Bertario ◽  
Paola Sala ◽  
Paolo Radice ◽  
Stefano Signoroni ◽  
Giovanni Ballardini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Predictive Model ◽  
Cancer Occurrence ◽  
Metachronous Colorectal Cancer
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