scholarly journals New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients

2016 ◽  
Vol 17 (4) ◽  
pp. 541-546 ◽  
Author(s):  
Hanna Romanowicz ◽  
Dominik Strapagiel ◽  
Marcin Słomka ◽  
Marta Sobalska-Kwapis ◽  
Ewa Kępka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Homologous Recombination ◽  
Single Nucleotide Polymorphisms ◽  
Cancer Patients ◽  
Homologous Recombination Repair ◽  
Nucleotide Polymorphisms ◽  
Breast Cancer Patients ◽  
Single Nucleotide ◽  
Recombination Repair ◽  
Repair Genes

scholarly journals New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients

2016 ◽  
Author(s):  
Hanna Romanowicz ◽  
Dominik Strapagiel ◽  
Marcin Slomka ◽  
Marta Sobalska-Kwapis ◽  
Ewa Kepka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Homologous Recombination ◽  
Single Nucleotide Polymorphisms ◽  
Cancer Patients ◽  
Homologous Recombination Repair ◽  
Nucleotide Polymorphisms ◽  
Breast Cancer Patients ◽  
Single Nucleotide ◽  
Recombination Repair ◽  
Repair Genes

Purpose of the study: Breast cancer is the most common cause of malignancy mortality in women worldwide. This study aimed at localising homologous recombination repair (HR) genes and their chromosomal loci and correlating their nucleotide variants with susceptibility to breast cancer. In this study authors analysed the association between single nucleotide polymorphisms (SNPs) in homologous recombination repair genes and the incidence of breast cancer in the population of Polish women. Methods: Blood samples from 94 breast cancer patients were analysed as test group. Individuals were recruited into the study at the Department of Oncological Surgery and Breast Diseases of the Institute of the Polish Mother Memorial Hospital in Lodz, Poland. Healthy controls (n=500) were obtained from the Biobank Laboratory, Department of Molecular Biophysics, University of Lodz. Then, DNA of breast cancer patients was compared with one of disease-free women. The test was supported by microarray analysis. Results: Statistically significant correlations were identified between breast cancer and 3 not described previously single nucleotide polymorphisms (SNPs) of homologous recombination repair genes BRCA1 and BRCA2: rs59004709, rs4986852 and rs1799950. Conclusions: Further studies on larger groups are warranted to support the hypothesis of correlation between the above-mentioned genetic variants and breast cancer risk.

Single Nucleotide Polymorphisms in the Homologous Recombination Repair Genes and Breast Cancer Risk in Polish Women

2011 ◽  
Vol 224 (3) ◽  
pp. 201-208 ◽  
Author(s):  
Hanna Romanowicz-Makowska ◽  
Beata Smolarz ◽  
Marek Zadrozny ◽  
Boguslaw Westfal ◽  
Jakub Baszczynski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Homologous Recombination ◽  
Cancer Risk ◽  
Single Nucleotide Polymorphisms ◽  
Homologous Recombination Repair ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Recombination Repair ◽  
Repair Genes
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