Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains

2021 ◽  
Author(s):  
Harshita Narang ◽  
Bruno V. Rego ◽  
Amir H. Khalighi ◽  
Ahmed Aly ◽  
Alison M. Pouch ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Ischemic Mitral Regurgitation ◽  
Valve Leaflet ◽  
Mitral Valve Leaflet

Severe Mitral Regurgitation Due to a “Folded” Anterior Mitral Valve Leaflet After Bentall Procedure Requiring Mitral Valve Replacement

2018 ◽  
Vol 32 (3) ◽  
pp. 1337-1340
Author(s):  
Jose R. Navas-Blanco ◽  
Stephanie A. Cook ◽  
Carlos Guerra-Londono ◽  
Jamil Borgi ◽  
Joseph A. Sanders ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Severe Mitral Regurgitation ◽  
Valve Leaflet ◽  
Mitral Valve Leaflet ◽  
Bentall Procedure

scholarly journals Successful percutaneous mitral valve leaflet repair for primary mitral regurgitation results in functional improvement and positive cardiac reverse remodelling

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
TP Craven ◽  
PG Chew ◽  
M Gorecka ◽  
LAE Brown ◽  
A Das ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Ejection Fraction ◽  
Left Ventricular ◽  
Valve Leaflet ◽  
Reference Standard ◽  
Mitral Valve Leaflet ◽  
Reverse Remodelling ◽  
Primary Mitral Regurgitation

Abstract Funding Acknowledgements Type of funding sources: None. Background Percutaneous mitral valve leaflet repair can be an effective treatment for primary mitral regurgitation (MR) patients deemed high-risk for surgery. Accurate assessment of cardiac reverse remodelling is essential to optimise future patient selection. Cardiovascular magnetic resonance (CMR) is the reference standard for cardiac volumetric assessment and compared to transthoracic echocardiography (TTE) provides superior reproducibility in MR quantification. Prior CMR studies have analysed cardiac reverse remodelling following percutaneous intervention in combined cohorts of primary and secondary MR patients. However, as aetiology of MR can significantly impact outcomes, focused studies are warranted. Purpose Assess cardiac reverse remodelling and quantify changes in MR following percutaneous mitral valve leaflet repair for primary MR using the reference standard (CMR). Methods 12 patients with at least moderate-severe MR on TTE were prospectively recruited to undergo CMR imaging and 6-minute walk tests (6MWT) at baseline and 6 months following percutaneous mitral valve leaflet repair (MitraClip). CMR protocol involved: left-ventricular (LV) short axis cines (bSSFP, SENSE-2, 10mm, no gap), transaxial right-ventricular (RV) cines (bSSFP, SENSE-2, 8mm, no gap), two and four chamber cines and aortic through-plane phase contrast imaging, planned at the sino-tubular junction. MR was quantified indirectly using LV and aortic stroke volumes. Results 12 patients underwent percutaneous mitral valve leaflet repair (MitraClip) for posterior mitral valve leaflet prolapse, however 1 patient declined follow up after single-leaflet clip detachment resulting in 11 patients (age 83 ± 5years, 9 male) completing follow up imaging. At 6-months: significant improvements occurred in New York Heart Association functional class (Table 1) and 6MWT distances (223 ± 71m to 281 ± 65m, p = 0.005) and significant reductions occurred in indexed left ventricular end-diastolic volumes (LVEDVi) (118 ± 21ml/m2 to 94 ± 27ml/m2, p = 0.001), indexed left ventricular end-systolic volumes (58 ± 19ml/m2 to 48 ± 21ml/m2, p = 0.007) and quantitated MR volume (55 ± 22ml to 24 ± 12ml, p = 0.003) and MR fraction (49 ± 9.4% to 29 ± 14%, p= <0.001). There were no statistically significant changes in left ventricular ejection fraction (LVEF), right ventricular dimensions/ejection fraction or bi-atrial dimensions (Table 1). All patients demonstrated decreased LVEDVi and quantified MR (Figure 1). Conclusion Successful percutaneous mitral valve leaflet repair for primary MR results in reduction in MR, positive LV reverse remodelling, preservation of LVEF, and functional improvements. Larger CMR studies are now required to further guide optimal patient selection.

scholarly journals Mitral Regurgitation Secondary to Cleft Posterior Mitral Valve Leaflet Defect

2014 ◽  
Vol 82 (3) ◽  
pp. 231-231
Author(s):  
Héctor Deschle ◽  
Rafaela Pinto Reyes
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Valve Leaflet ◽  
Mitral Valve Leaflet

Isolated cleft of the posterior mitral valve leaflet with mitral valve prolapse

2018 ◽  
pp. 1-3
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Left Ventricular ◽  
Valve Leaflet ◽  
Cardiac Murmur ◽  
Mitral Valve Leaflet ◽  
Excellent Outcome ◽  
Normal Left Ventricular ◽  
Congenital Mitral Regurgitation ◽  
And Function

Isolated cleft of posterior mitral valve leaflet is a very rare cause of congenital mitral regurgitation. We present a 56-year-old woman referred for an echocardiogram by her physician for evaluation of a cardiac murmur. The echocardiogram showed normal left ventricular sizes and function; an isolated cleft of the posterior mitral valve leaflet with posterior leaflet prolapse causing severe mitral regurgitation. The patient was treated surgically with excellent outcome.

scholarly journals Infective Endocarditis of the Aortic Valve with Anterior Mitral Valve Leaflet Aneurysm

2016 ◽  
Vol 43 (4) ◽  
pp. 345-349 ◽  
Author(s):  
Anton Tomsic ◽  
Wilson W.L. Li ◽  
Marieke van Paridon ◽  
Navin R. Bindraban ◽  
Bas A.J.M. de Mol
Keyword(s):  
Heart Failure ◽  
Infective Endocarditis ◽  
Mitral Valve ◽  
Aortic Valve ◽  
Mitral Regurgitation ◽  
Antibiotic Therapy ◽  
Medical Literature ◽  
Severe Mitral Regurgitation ◽  
Valve Leaflet ◽  
Mitral Valve Leaflet

Mitral valve leaflet aneurysm is a rare and potentially devastating complication of aortic valve endocarditis. We report the case of a 48-year-old man who had endocarditis of the native aortic valve and a concomitant aneurysm of the anterior mitral valve leaflet. Severe mitral regurgitation occurred after the aneurysm perforated. The patient showed no signs of heart failure and completed a 6-week regimen of antibiotic therapy before undergoing successful aortic and mitral valve replacement. In addition to the patient's case, we review the relevant medical literature.

scholarly journals POSTERIOR MITRAL VALVE LEAFLET HYPOPLASIA: AN UNUSUAL PRESENTATION OF MITRAL REGURGITATION

2019 ◽  
Vol 73 (9) ◽  
pp. 2359 ◽  
Author(s):  
Tarun Tandon ◽  
Aashay Patel ◽  
Jeff Murray ◽  
Arun Kanmanthareddy
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Unusual Presentation ◽  
Valve Leaflet ◽  
Mitral Valve Leaflet
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