Analysis of longevity in Chordata identifies species with exceptional longevity among taxa and points to the evolution of longer lifespans

2021 ◽  
Author(s):  
Caglar Berkel ◽  
Ercan Cacan
Keyword(s):  
Exceptional Longevity

scholarly journals Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study

2020 ◽  
Vol Volume 15 ◽  
pp. 733-742
Author(s):  
Mengjing Wang ◽  
Xuehui Sun ◽  
Li Ni ◽  
Minmin Zhang ◽  
Jiaying Zhang ◽  
...  
Keyword(s):  
Comparative Performance ◽  
Exceptional Longevity ◽  
Estimation Equations ◽  
Ageing Study ◽  
Gfr Estimation

scholarly journals Reduced Prevalence of Cognitive Impairment in Families With Exceptional Longevity

2013 ◽  
Vol 70 (7) ◽  
pp. 867 ◽  
Author(s):  
Stephanie Cosentino ◽  
Nicole Schupf ◽  
Kaare Christensen ◽  
Stacy L. Andersen ◽  
Anne Newman ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Exceptional Longevity

scholarly journals SEX-DIMORPHISM IN THE GENOMIC REGULATION OF AGING

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S768-S769
Author(s):  
Bérénice A Benayoun ◽  
Ryan A Lu ◽  
Nirmal K Sampathkumar
Keyword(s):  
Inflammatory Cytokines ◽  
Rna Seq ◽  
Male Mice ◽  
Sex Dimorphism ◽  
Exceptional Longevity ◽  
Cytokine Levels ◽  
Genomic Regulation ◽  
Pro Inflammatory Cytokines

Abstract The current cohort of human supercentenarians reveals a surprising predictor for achieving such an exceptional longevity: being female. Indeed, out of 34 living supercentenarians, 33 are women. We obtained samples from 4 and 20 months old female and male mice. Our data indicates that cytokine levels are differentially regulated with age in males vs. females, with pro-inflammatory cytokines specifically upregulated in the serum of old males, but not females. Because of the central role of macrophages in inflammation and their infiltration in tissues with age, we have generated RNA-seq from purified macrophages of aging animals. Female macrophages displayed ~7-20-fold more transcriptional remodeling with aging than males. Pathways specifically downregulated in females with aging included lysosome, inflammation and phagolysosome. Consistently, our data shows that aged female, but not male macrophages, display decreased phagocytic efficiency. Our results support the notion that there are differences in aging trajectories in female vs. male mice.

Genetics of exceptional longevity

2003 ◽  
Vol 38 (7) ◽  
pp. 725-730 ◽  
Author(s):  
Thomas Perls ◽  
Dellara Terry
Keyword(s):  
Exceptional Longevity
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