On-site evaluation of CT-based fractional flow reserve using simple boundary conditions for computational fluid dynamics

2019 ◽  
Vol 36 (2) ◽  
pp. 337-346 ◽  
Author(s):  
Yusuke Yoshikawa ◽  
Masahiko Nakamoto ◽  
Masanori Nakamura ◽  
Takeharu Hoshi ◽  
Erika Yamamoto ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Boundary Conditions ◽  
Fractional Flow Reserve ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Simple Boundary ◽  
Site Evaluation

Fractional flow reserve derived from conventional coronary angiograms and computational fluid dynamics

2015 ◽  
Vol 190 ◽  
pp. 187-189 ◽  
Author(s):  
Anastasios Kopanidis ◽  
Ioannis Pantos ◽  
Andreas Theodorakakos ◽  
Efthalia Tzanalaidou ◽  
Demosthenes Katritsis
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Fractional Flow Reserve ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Coronary Angiograms

scholarly journals Fractional Flow Reserve Computed from Noninvasive CT Angiography Data: Diagnostic Performance of an On-Site Clinician-operated Computational Fluid Dynamics Algorithm

Radiology ◽  
2015 ◽  
Vol 274 (3) ◽  
pp. 674-683 ◽  
Author(s):  
Adriaan Coenen ◽  
Marisa M. Lubbers ◽  
Akira Kurata ◽  
Atsushi Kono ◽  
Admir Dedic ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Ct Angiography ◽  
Fractional Flow Reserve ◽  
Diagnostic Performance ◽  
Fractional Flow ◽  
Flow Reserve

scholarly journals The relationship between coronary stenosis morphology and fractional flow reserve: a computational fluid dynamics modelling study

2021 ◽  
Author(s):  
Roberto T F Newcombe ◽  
Rebecca C Gosling ◽  
Vignesh Rammohan ◽  
Patricia V Lawford ◽  
D Rodney Hose ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Coronary Artery ◽  
Fractional Flow Reserve ◽  
Computational Modelling ◽  
Fractional Flow ◽  
Cfd Modelling ◽  
Flow Reserve ◽  
The Relationship ◽  
Lesion Severity

Abstract Background International guidelines mandate the use of fractional flow reserve (FFR) and/or non-hyperaemic pressure ratios to assess the physiological significance of moderate coronary artery lesions to guide revascularisation decisions. However, they remain underused such that visual estimation of lesion severity continues to be the predominant decision-making tool. It would be pragmatic to have an improved understanding of the relationship between lesion morphology and haemodynamics. Aims To compute virtual FFR (vFFR) in idealised coronary artery geometries with a variety of stenosis and vessel characteristics Methods Coronary artery geometries were modelled, based upon physiologically realistic branched arteries. Common stenosis characteristics were studied, including % narrowing, length, eccentricity, shape, number, position relative to branch, and distal (myocardial) resistance. Computational fluid dynamics (CFD) modelling was used to calculate vFFRs using the VIRTUheartTM system. Results Percentage lesion severity had the greatest effect upon FFR. Any ≥80% diameter stenosis in two views (i.e. concentric) was physiologically significant (FFR ≤ 0.80), irrespective of length, shape or vessel diameter. Almost all eccentric stenoses and all 50% concentric stenoses were physiologically non-significant, whilst 70% uniform concentric stenoses about 10mm long straddled the ischaemic threshold (FFR 0.80). A low microvascular resistance (MVR) reduced FFR on average by 0.05, and a high MVR increased it by 0.03. Conclusions Using computational modelling, we have produced an analysis of virtual FFR that relates stenosis characteristics to haemodynamic significance. The strongest predictor of a positive virtual FFR was a concentric, ≥80% diameter stenosis. The importance of MVR was quantified. Other lesion characteristics have a limited impact.

The influence of artery wall curvature on the anatomical assessment of stenosis severity derived from fractional flow reserve: a computational fluid dynamics study

2016 ◽  
Vol 19 (14) ◽  
pp. 1541-1549 ◽  
Author(s):  
Kalimuthu Govindaraju ◽  
Girish N. Viswanathan ◽  
Irfan Anjum Badruddin ◽  
Sarfaraz Kamangar ◽  
N. J. Salman Ahmed ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Fractional Flow Reserve ◽  
Artery Wall ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Stenosis Severity

scholarly journals Fractional Flow Reserve Derived from Coronary Imaging and Computational Fluid Dynamics

2014 ◽  
Vol 9 (3) ◽  
pp. 145 ◽  
Author(s):  
Ioannis Pantos ◽  
Demosthenes Katritsis ◽  
◽  
Keyword(s):  
Fluid Dynamics ◽  
Coronary Artery Disease ◽  
Computational Fluid Dynamics ◽  
Coronary Artery ◽  
Fractional Flow Reserve ◽  
Fractional Flow ◽  
Artery Cannulation ◽  
Flow Reserve ◽  
Artery Disease

The assessment of functional severity of atherosclerotic stenoses in patients with coronary artery disease by invasive fractional flow reserve (FFR) measurement requires coronary artery cannulation, advancement of a wire and intravenous adenosine infusion with inherent procedure-related risk and costs. Coronary computed tomographic angiography (CCTA) and rotational coronary angiography (RA) have been recently used in conjunction with computational fluid dynamics (CFD) and image-based modelling for the determination of FFR without the need for additional imaging, modification of acquisition protocols or administration of medication. FFR derived from CCTA was demonstrated as superior to measures of CCTA stenosis severity for determination of lesion-specific ischaemia. Estimation of FFR from RA images and CFD provides a less invasive alternative to conventional FFR measurement while estimated values are in agreement with measured values. These new, combined anatomic–functional assessments have the potential to simplify the noninvasive diagnosis of coronary artery disease with a single study to identify patients with ischaemia-causing stenosis who may benefit from revascularisation.

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