Neuroprotective Effect of Lutein on NMDA-Induced Retinal Ganglion Cell Injury in Rat Retina

2015 ◽  
Vol 36 (4) ◽  
pp. 531-540 ◽  
Author(s):  
Chanjuan Zhang ◽  
Zhen Wang ◽  
Jiayi Zhao ◽  
Qin Li ◽  
Cuiqin Huang ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Rat Retina

scholarly journals Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michal Geva ◽  
Noga Gershoni-Emek ◽  
Luana Naia ◽  
Philip Ly ◽  
Sandra Mota ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Degeneration ◽  
Retinal Ganglion Cells ◽  
Retinal Ganglion Cell ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Cell Degeneration ◽  
Sigma 1 Receptor ◽  
Sigma 1

AbstractOptic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes retinal degeneration. Activation of the S1R exerts neuroprotective effects in models of retinal degeneration. Pridopidine is a highly selective and potent S1R agonist in clinical development. We show that pridopidine exerts neuroprotection of retinal ganglion cells in two different rat models of glaucoma. Pridopidine strongly binds melanin, which is highly expressed in the retina. This feature of pridopidine has implications to its ocular distribution, bioavailability, and effective dose. Mitochondria dysfunction is a key contributor to retinal ganglion cell degeneration. Pridopidine rescues mitochondrial function via activation of the S1R, providing support for the potential mechanism driving its neuroprotective effect in retinal ganglion cells.

Gadd45α affects retinal ganglion cell injury in chronic ocular hypertension rats by regulating p38MAPK pathway

Gene ◽  
2020 ◽  
Vol 763 ◽  
pp. 145030
Author(s):  
Rui-Xue Sun ◽  
Zhao-Hui Sun ◽  
Qian Ren ◽  
Li Li ◽  
Li Yin ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion ◽  
P38mapk Pathway

Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina

2010 ◽  
Vol 91 (6) ◽  
pp. 800-810 ◽  
Author(s):  
Diego García-Ayuso ◽  
Manuel Salinas-Navarro ◽  
Marta Agudo ◽  
Nicolás Cuenca ◽  
Isabel Pinilla ◽  
...  
Keyword(s):  
Cell Death ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Rat Retina ◽  
Cell Numbers ◽  
Retinal Ganglion Cell Death ◽  
Ganglion Cell Death

scholarly journals Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage

2010 ◽  
Vol 11 (1) ◽  
pp. 125 ◽  
Author(s):  
Rajkumar Tulsawani ◽  
Lorena S Kelly ◽  
Nigar Fatma ◽  
Bhavanaben Chhunchha ◽  
Eri Kubo ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Damage ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Peroxiredoxin 6

scholarly journals Mechanisms of retinal ganglion cell injury and defense in glaucoma

2010 ◽  
Vol 91 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Juan Qu ◽  
Danyi Wang ◽  
Cynthia L. Grosskreutz
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion

Neuroprotective effect of melatonin against hypoxia-induced retinal ganglion cell death in neonatal rats

2012 ◽  
Vol 54 (2) ◽  
pp. 190-206 ◽  
Author(s):  
Charanjit Kaur ◽  
Viswanathan Sivakumar ◽  
Remya Robinson ◽  
Wallace S. Foulds ◽  
Chi D. Luu ◽  
...  
Keyword(s):  
Cell Death ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Neonatal Rats ◽  
Retinal Ganglion Cell Death ◽  
Ganglion Cell Death

Mechanisms of Retinal Ganglion Cell Injury in Aging and Glaucoma

2010 ◽  
Vol 44 (3) ◽  
pp. 173-178 ◽  
Author(s):  
Vicki Chrysostomou ◽  
Ian A. Trounce ◽  
Jonathan G. Crowston
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion
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