scholarly journals Neuroprotective effect of Qinggan Lishui formula on retinal ganglion cell apoptosis in a microbead-induced rat chronic glaucoma model

2018 ◽  
Vol 38 (2) ◽  
pp. 175-181
Author(s):  
Zhang Cheng ◽  
Chen Yanqiu ◽  
Li Fang ◽  
Wang Zhongfeng ◽  
Zhang Yinjian
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Apoptosis ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Chronic Glaucoma

scholarly journals Asiatic Acid Prevents Retinal Ganglion Cell Apoptosis in a Rat Model of Glaucoma

2018 ◽  
Vol 12 ◽  
Author(s):  
Wanjing Huang ◽  
Fengjuan Gao ◽  
Fangyuan Hu ◽  
Jiancheng Huang ◽  
Min Wang ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Rat Model ◽  
Cell Apoptosis ◽  
Asiatic Acid ◽  
Retinal Ganglion

scholarly journals Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michal Geva ◽  
Noga Gershoni-Emek ◽  
Luana Naia ◽  
Philip Ly ◽  
Sandra Mota ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Degeneration ◽  
Retinal Ganglion Cells ◽  
Retinal Ganglion Cell ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Cell Degeneration ◽  
Sigma 1 Receptor ◽  
Sigma 1

AbstractOptic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absence causes retinal degeneration. Activation of the S1R exerts neuroprotective effects in models of retinal degeneration. Pridopidine is a highly selective and potent S1R agonist in clinical development. We show that pridopidine exerts neuroprotection of retinal ganglion cells in two different rat models of glaucoma. Pridopidine strongly binds melanin, which is highly expressed in the retina. This feature of pridopidine has implications to its ocular distribution, bioavailability, and effective dose. Mitochondria dysfunction is a key contributor to retinal ganglion cell degeneration. Pridopidine rescues mitochondrial function via activation of the S1R, providing support for the potential mechanism driving its neuroprotective effect in retinal ganglion cells.

In vivo imaging of retinal ganglion cell apoptosis

2013 ◽  
Vol 13 (1) ◽  
pp. 123-127 ◽  
Author(s):  
Joana Galvao ◽  
Benjamin M Davis ◽  
Maria Francesca Cordeiro
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Apoptosis ◽  
In Vivo Imaging ◽  
Retinal Ganglion
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