Mechanisms of Retinal Ganglion Cell Injury in Aging and Glaucoma

2010 ◽  
Vol 44 (3) ◽  
pp. 173-178 ◽  
Author(s):  
Vicki Chrysostomou ◽  
Ian A. Trounce ◽  
Jonathan G. Crowston
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion

Gadd45α affects retinal ganglion cell injury in chronic ocular hypertension rats by regulating p38MAPK pathway

Gene ◽  
2020 ◽  
Vol 763 ◽  
pp. 145030
Author(s):  
Rui-Xue Sun ◽  
Zhao-Hui Sun ◽  
Qian Ren ◽  
Li Li ◽  
Li Yin ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion ◽  
P38mapk Pathway

scholarly journals Mechanisms of retinal ganglion cell injury and defense in glaucoma

2010 ◽  
Vol 91 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Juan Qu ◽  
Danyi Wang ◽  
Cynthia L. Grosskreutz
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion

Neuroprotective Effect of Lutein on NMDA-Induced Retinal Ganglion Cell Injury in Rat Retina

2015 ◽  
Vol 36 (4) ◽  
pp. 531-540 ◽  
Author(s):  
Chanjuan Zhang ◽  
Zhen Wang ◽  
Jiayi Zhao ◽  
Qin Li ◽  
Cuiqin Huang ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Rat Retina

Acute retinal ganglion cell injury caused by intraocular pressure spikes is mediated by endogenous extracellular ATP

2007 ◽  
Vol 25 (9) ◽  
pp. 2741-2754 ◽  
Author(s):  
Valentina Resta ◽  
Elena Novelli ◽  
Giovanni Vozzi ◽  
Cristiano Scarpa ◽  
Matteo Caleo ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Extracellular Atp ◽  
Retinal Ganglion

scholarly journals Comparison of Glaucoma-Relevant Transcriptomic Datasets Identifies Novel Drug Targets for Retinal Ganglion Cell Neuroprotection

2021 ◽  
Vol 10 (17) ◽  
pp. 3938
Author(s):  
Tim J. Enz ◽  
James R. Tribble ◽  
Pete A. Williams
Keyword(s):  
Valproic Acid ◽  
Folic Acid ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Drug Targets ◽  
Cell Injury ◽  
Ganglion Cells ◽  
Significant Proportion ◽  
Retinal Ganglion ◽  
Sequencing Data

Glaucoma is a leading cause of blindness and is characterized by the progressive dysfunction and irreversible death of retinal ganglion cells. We aimed to identify shared differentially expressed genes (DE genes) between different glaucoma relevant models of retinal ganglion cell injury using existing RNA-sequencing data, thereby discovering targets for neuroprotective therapies. A comparison of DE genes from publicly available transcriptomic datasets identified 12 shared DE genes. The Comparative Toxicogenomics Database (CTD) was screened for compounds targeting a significant proportion of the identified DE genes. Forty compounds were identified in the CTD that interact with >50% of these shared DE genes. We next validated this approach by testing select compounds for an effect on retinal ganglion cell survival using a mouse retinal explant model. Folic acid, genistein, SB-431542, valproic acid, and WY-14643 (pirinixic acid) were tested. Folic acid, valproic acid, and WY-14643 demonstrated significant protection against retinal ganglion cell death in this model. The increasing prevalence of open access-omics data presents a resource to discover targets for future therapeutic investigation.

The Effect of Retinal Ganglion Cell Injury on Light-Induced Photoreceptor Degeneration

2004 ◽  
Vol 45 (2) ◽  
pp. 685 ◽  
Author(s):  
Robert J. Casson ◽  
Glyn Chidlow ◽  
John P. M. Wood ◽  
Manuel Vidal-Sanz ◽  
Neville N. Osborne
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion ◽  
Photoreceptor Degeneration
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