Monitoring and assessment of the therapeutic impact of metabolites extracted from sponge-associated bacteria screened from Gulf of Mannar, southeast coast of India

2020 ◽  
Vol 192 (4) ◽  
Author(s):  
Sinosh Skariyachan ◽  
Sneha Basavaraj Challapilli ◽  
Swathi Packirisamy ◽  
Vaishnavi Sneha Sridhar ◽  
Supreetha Toplar Kumargowda
2020 ◽  
Vol 141 ◽  
pp. 103972 ◽  
Author(s):  
Raju Rajasabapathy ◽  
Sanjeev C. Ghadi ◽  
Balakrishnan Manikandan ◽  
Chellandi Mohandass ◽  
Akhila Surendran ◽  
...  

2016 ◽  
Vol 62 (8) ◽  
pp. 668-681 ◽  
Author(s):  
B. Thilakan ◽  
K. Chakraborty ◽  
R.D. Chakraborty

In this study, 234 bacterial strains were isolated from 7 seaweed species in the Gulf of Mannar on the southeast coast of India. The strains having consistent antimicrobial activity were chosen for further studies, and this constituted about 9.8% of the active strains isolated. Phylogenetic analysis using 16S rDNA sequencing with the help of classical biochemical identification indicated the existence of 2 major phyla, Firmicutes and Proteobacteria. Antimicrobial activity analysis combined with the results of amplifying genes encoding for polyketide synthetase and nonribosomal peptide synthetase showed that seaweed-associated bacteria had broad-spectrum antimicrobial activity. These epibionts might be beneficial to seaweeds by limiting or preventing the development of competing or fouling bacteria. Phylogenetic analysis of ketosynthase (KS) regions with respect to the diverse range of KS domains showed that the KS domains from the candidate isolates were of Type I. The bacterial cultures retained their antimicrobial activities after plasmid curing, which further suggested that the antimicrobial activity of these isolates was not encoded by plasmid, and the genes encoding the antimicrobial product might be present within the genome. Seaweed-associated bacteria with potential antimicrobial activity suggested that the seaweed species are an ideal ecological niche harboring specific bacterial diversity representing a largely underexplored source of antimicrobial secondary metabolites.


2013 ◽  
Vol 110 ◽  
pp. 27-48 ◽  
Author(s):  
L. Jagadeesan ◽  
R. Jyothibabu ◽  
A. Anjusha ◽  
Arya P. Mohan ◽  
N.V. Madhu ◽  
...  

2013 ◽  
Vol 115-116 ◽  
pp. 40-61 ◽  
Author(s):  
A. Anjusha ◽  
R. Jyothibabu ◽  
L. Jagadeesan ◽  
Arya P. Mohan ◽  
K. Sudheesh ◽  
...  

2016 ◽  
Vol 4 (8) ◽  
pp. 608-611 ◽  
Author(s):  
Jayanthi Govindarajalu ◽  
◽  
Muthusamy Anand ◽  
Gurusamy Chelladurai ◽  
Arumugam Kumaraguru ◽  
...  

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