Benefits and risks of low molecular weight heparin in patients with acute exacerbation of chronic obstructive pulmonary disease: a meta-analysis of randomized controlled trials

2019 ◽  
Vol 28 (2) ◽  
pp. 451-462
Author(s):  
Mingjin Yang ◽  
Ying Xu ◽  
Hong Chen ◽  
Zhibo Xu ◽  
Fengming Luo
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Molecular Weight ◽  
Randomized Controlled Trials ◽  
Low Molecular Weight Heparin ◽  
Meta Analysis ◽  
Chronic Obstructive ◽  
Controlled Trials ◽  
Low Molecular Weight ◽  
Obstructive Pulmonary Disease ◽  
Randomized Controlled

scholarly journals Mind-Body Exercise (Wuqinxi) for Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2018 ◽  
Vol 16 (1) ◽  
pp. 72 ◽  
Author(s):  
Ke Wang ◽  
Shijie Liu ◽  
Zhaowei Kong ◽  
Yanjie Zhang ◽  
Jing Liu
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Randomized Controlled Trials ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Chronic Obstructive ◽  
Controlled Trials ◽  
Intervention Component ◽  
Obstructive Pulmonary Disease ◽  
Training Time ◽  
Randomized Controlled

Objective: This study is the first meta-analysis investigating the rehabilitative effects of Wuqinxi for patients with chronic obstructive pulmonary disease (COPD). Methods: Five electronic databases (PubMed, Web of Science, Scopus, CNKI, and Wanfang) from inception until early November 2018 were searched. All randomized controlled trials (RCT) using Wuqinxi as the main intervention component were included for meta-analysis. The pooled effect sizes (Standardized mean difference, SMD) were calculated to determine the magnitude of the Wuqinxi intervention effect. Moderator analysis was only conducted for total training time. Results: Overall results of the meta-analysis indicated that Wuqinxi exercise significantly improved exercise capability (SMD = 1.18, 95% CI 0.53 to 1.84, e < 0.001, I2 = 84.97%), FEV1 (SMD = 0.44, 95% CI 0.12 to 0.77, e < 0.001, I2 = 33.77%), FEV1% (SMD = 0.59, 95% CI 0.24 to 0.93, e < 0.001, I2 = 63.79%), FEV1/FVC (SMD = 0.65, 95% CI 0.37 to 0.93, e = 0.006, I2 = 44.32%) and CCQ (SMD = 1.23, 95% CI 0.31 to 2.14, e = 0.01, I2 = 93.32%). Conclusions: With no occurrence of adverse event, clinicians could try to incorporate Wuqinxi exercise into their first-line rehabilitation regime for COPD patients.

scholarly journals Meta-analysis of Different Pressing Time on the Incidence of Subcutaneous Hemorrhage of Low Molecular Weight Heparin Administration

2021 ◽  
Vol 27 ◽  
pp. 107602962110386
Author(s):  
Juan Fang ◽  
Gefeng Pan ◽  
Xufei Bao ◽  
Yanhong Wang
Keyword(s):  
Molecular Weight ◽  
Randomized Controlled Trials ◽  
Low Molecular Weight Heparin ◽  
Meta Analysis ◽  
Biomedical Literature ◽  
Controlled Trials ◽  
Low Molecular Weight ◽  
Bleeding Rate ◽  
Randomized Controlled ◽  
Pressing Time

To investigate the effect of different pressing time on the incidence of subcutaneous hemorrhage of low molecular weight heparin (LMWH) administration by meta-analysis. Cochrane Library, PubMed, MEDLINE, CINAHL, EMbase, Springer, EBSCO, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database were searched. To screen the literature of randomized controlled trials with different pressing time in patients with subcutaneous LMWH injection from the establishment of the database to December 2020. The quality of the literature was evaluated and the data were extracted. Meta-analysis was performed by RevMan 5.3. A total of 17 randomized controlled trials were included. Meta-analysis showed that the bleeding rate of pressing for 5 min odds ratio (OR  =  3.89, 95% confidence interval [CI]: 2.68-5.64, P < .05) or pressing for 10 min (OR  =  1.99, 95% CI: 1.34-2.95) was significantly lower than that of pressing for 3 min. Moreover, the bleeding rate was significantly lower in the 5 min pressing (OR  =  1.47, 95% CI: 1.18-1.82) and 10 min pressing(OR  =  2.12, 95% CI: 1.61-2.77) than in the no compression group. It is the most suitable time to press 5 min after subcutaneous LMWH injection, which can better control the incidence of bleeding.

scholarly journals Comparative Efficacy of Chinese Herbal Injections for Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Xiaojiao Duan ◽  
Jiarui Wu ◽  
Xingyue Huang ◽  
Kaihuan Wang ◽  
Yi Zhao ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Randomized Controlled Trials ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Meta Analysis ◽  
Chronic Obstructive ◽  
Controlled Trials ◽  
Obstructive Pulmonary Disease ◽  
Randomized Controlled ◽  
Chinese Herbal

Introduction. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) imposes a huge economic burden on healthcare systems worldwide. Chinese herbal injections (CHIs) are widely used to treat AECOPD. In this study, we examined the efficacy of CHIs in the treatment of AECOPD using a network meta-analysis (NMA). Methods. Literature search was conducted from electronic databases of randomized controlled trials (RCTs) on CHIs plus Western medicine (WM) versus WM. WinBUGS 1.4.3 and STATA 12.0 were adopted to compute calculations and prepare graphs, respectively. Results. We included 155 RCTs with 13,218 patients. The results revealed that Danhong injection (DH) + WM had the greatest therapeutic potential in terms of rate of clinical efficacy (RCE). In addition, in comprehensively improving RCE and FEV1%, and RCE and C-reactive protein, Huangqi injection (HQ) +WM was associated with preferable effects. Similarly, Xixinnao injection + WM, Reduning injection (RDN) +WM, and HQ+WM had a favorable effect on RCE and PaO2. The effect of RDN+WM was favorable in all outcomes except RCE. The safety of CHIs needs to be further assessed. Conclusions. Based on this NMA, DH+WM, HQ+WM, and RDN+WM were potential optimal therapies in AECOPD and their safety should be strictly monitored.

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