Factor Xa Inhibitors versus Low Molecular Weight Heparin for The Treatment of Cancer Associated Venous Thromboembolism; A Meta-Analysis of Randomized Controlled Trials and Non-Randomized Studies

2021 ◽  
pp. 103526
Author(s):  
Maryam R. Hussain ◽  
Faisal S. Ali ◽  
Dhiran Verghese ◽  
Phyo Thazin Myint ◽  
Mubashir Ahmed ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Venous Thromboembolism ◽  
Randomized Controlled Trials ◽  
Low Molecular Weight Heparin ◽  
Meta Analysis ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Controlled Trials ◽  
Low Molecular Weight ◽  
Randomized Controlled

scholarly journals Meta-analysis of Different Pressing Time on the Incidence of Subcutaneous Hemorrhage of Low Molecular Weight Heparin Administration

2021 ◽  
Vol 27 ◽  
pp. 107602962110386
Author(s):  
Juan Fang ◽  
Gefeng Pan ◽  
Xufei Bao ◽  
Yanhong Wang
Keyword(s):  
Molecular Weight ◽  
Randomized Controlled Trials ◽  
Low Molecular Weight Heparin ◽  
Meta Analysis ◽  
Biomedical Literature ◽  
Controlled Trials ◽  
Low Molecular Weight ◽  
Bleeding Rate ◽  
Randomized Controlled ◽  
Pressing Time

To investigate the effect of different pressing time on the incidence of subcutaneous hemorrhage of low molecular weight heparin (LMWH) administration by meta-analysis. Cochrane Library, PubMed, MEDLINE, CINAHL, EMbase, Springer, EBSCO, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database were searched. To screen the literature of randomized controlled trials with different pressing time in patients with subcutaneous LMWH injection from the establishment of the database to December 2020. The quality of the literature was evaluated and the data were extracted. Meta-analysis was performed by RevMan 5.3. A total of 17 randomized controlled trials were included. Meta-analysis showed that the bleeding rate of pressing for 5 min odds ratio (OR  =  3.89, 95% confidence interval [CI]: 2.68-5.64, P < .05) or pressing for 10 min (OR  =  1.99, 95% CI: 1.34-2.95) was significantly lower than that of pressing for 3 min. Moreover, the bleeding rate was significantly lower in the 5 min pressing (OR  =  1.47, 95% CI: 1.18-1.82) and 10 min pressing(OR  =  2.12, 95% CI: 1.61-2.77) than in the no compression group. It is the most suitable time to press 5 min after subcutaneous LMWH injection, which can better control the incidence of bleeding.

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