Acute lupus choroidopathy: multimodal imaging and differential diagnosis from central serous chorioretinopathy

AbstractThis study aimed to identify the clinical characteristics and longitudinal changes in exudative pachychoroid neovasculopathy (PNV) and non-exudative PNV. This retrospective cohort study involved 81 eyes of PNV diagnosed by multimodal imaging including optical coherence tomography angiography. At baseline, they were divided into exudative PNV group and non-exudative PNV group depending on the presence of subretinal fluid. The clinical features of both groups and the longitudinal changes were investigated and compared. There were 55 eyes with non-exudative PNV and 26 eyes with exudative PNV. Individuals with non-exudative PNV were older, more frequently asymptomatic and had a higher prevalence of polypoidal choroidal vasculopathy in the opposite eye (all P’s < 0.05). Whereas individuals with exudative PNV showed thicker choroid and more frequent history of central serous chorioretinopathy (all P’s < 0.001). During about 12 months of longitudinal observation, the transformation into polypoidal choroidal vasculopathy was noted in 4 eyes of non-exudative PNV group, whereas in none of the exudative PNV group. Exudative PNV and non-exudative PNV seem to be separate entities with different epidemiological parameters. Non-exudative PNV, which is frequently found without symptoms at an older age, is suspected to be the significant precursor lesion of polypoidal choroidal vasculopathy. In contrast, exudative PNV may share the same pathophysiology as central serous chorioretinopathy.

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Application of Multimodal Imaging Biomarker in the Differential Diagnosis of Ovarian Mass

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000004008 ◽

2022 ◽

Vol 47 (2) ◽

pp. 117-122

Author(s):

Ji-In Bang ◽

Ji-Young Kim ◽

Min Chul Choi ◽

Ho-Young Lee ◽

Su Jin Jang

Keyword(s):

Differential Diagnosis ◽

Multimodal Imaging ◽

Imaging Biomarker ◽

Ovarian Mass

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Dark and white lesions observed in central serous chorioretinopathy on optical coherence tomography angiography

European Journal of Ophthalmology ◽

10.1177/1120672118758401 ◽

2018 ◽

Vol 28 (4) ◽

pp. 446-453 ◽

Cited By ~ 3

Author(s):

Flore De Bats ◽

Pierre-Loïc Cornut ◽

Benjamin Wolff ◽

Laurent Kodjikian ◽

Martine Mauget-Faÿsse

Keyword(s):

Optical Coherence Tomography ◽

Central Serous Chorioretinopathy ◽

Multimodal Imaging ◽

Optical Coherence Tomography Angiography ◽

Pigment Epithelium ◽

Serous Retinal Detachment ◽

Descriptive Study ◽

Dark Spot ◽

Optical Coherence ◽

Choroidal Neovascular Membrane

Purpose: To describe abnormal dark (hyposignal) and white (hypersignal) lesions observed on optical coherence tomography angiography in central serous chorioretinopathy. Methods: Prospective, multicenter, and descriptive study including patients with active or quiescent central serous chorioretinopathy. All patients had undergone a complete ophthalmic examination. Results: Abnormal dark lesions were detected as “dark spots” and “dark areas” on optical coherence tomography angiography. A “dark spot” could correspond to six different abnormalities: pigment epithelium detachment, subretinal deposit, “Lucency” within surrounding subretinal fibrin, choroidal cavitation, choroidal excavation, and choroidal fluid. A “dark area” could be related to a serous retinal detachment or choriocapillary compression. Abnormal white lesions were also detected: A “white spot” could correspond with the leaking point on fluorescein angiography or with hyper-reflective dots; A “white filamentous pattern” at the Brüch’s membrane level corresponded to abnormal choroidal neovascular vessels. Conclusion: A semiology is described using optical coherence tomography angiography in central serous chorioretinopathy as abnormal dark and white lesions. Multimodal imaging is mandatory in addition to optical coherence tomography angiography to diagnose non-neovascular retinal and choroidal central serous chorioretinopathy lesions. However, optical coherence tomography angiography alone is helpful in detecting choroidal neovascular membrane in central serous chorioretinopathy.

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Visual acuity correlates with multimodal imaging-based categories of central serous chorioretinopathy

Eye ◽

10.1038/s41433-021-01788-4 ◽

2021 ◽

Author(s):

Supriya Arora ◽

Dmitrii S. Maltsev ◽

Niroj Kumar Sahoo ◽

Deepika C. Parameshwarappa ◽

Claudio Iovino ◽

...

Keyword(s):

Visual Acuity ◽

Central Serous Chorioretinopathy ◽

Multimodal Imaging

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Multimodal Imaging Evaluations of Focal Choroidal Excavations in Eyes with Central Serous Chorioretinopathy

Journal of Ophthalmology ◽

10.1155/2016/7073083 ◽

2016 ◽

Vol 2016 ◽

pp. 1-12 ◽

Cited By ~ 7

Author(s):

Yao Wang ◽

Zhi-Qing Chen ◽

Wei Wang ◽

Xiao-Yun Fang

Keyword(s):

Central Serous Chorioretinopathy ◽

Multimodal Imaging ◽

Retinal Pigment Epithelial ◽

Multispectral Imaging ◽

Pigment Epithelium ◽

Fundus Autofluorescence ◽

Retinal Pigment ◽

Chinese Patients ◽

Single Institution ◽

Focal Choroidal Excavation

Purpose. To investigate the prevalence and characteristics of focal choroidal excavation (FCE) concurrent with central serous chorioretinopathy (CSC) using multimodal imaging.Methods. This was a retrospective single-institution study. Clinical features and multimodal imaging findings were analyzed in eyes with CSC and FCEs, using imaging methods including optical coherence tomography (OCT), OCT angiography (OCTA), fluorescein angiography (FA), indocyanine green angiography (ICGA), fundus autofluorescence (FAF), and multispectral imaging.Results. Seventeen patients (4.8%) with 21 FCEs (19 eyes) were found among 351 consecutive Chinese patients with CSC. Chronic CSC represented 47.1% of those cases. Window defects in 12 lesions identified through FA and hypoautofluorescence in 13 lesions identified through FAF revealed retinal pigment epithelial attenuation. Choroidal hemodynamic disturbances characterized by localized filling defects at the excavation and circumferential hyperperfusion were validated by both ICGA and OCTA, which were similar to the angiographic features of normal chronic CSC. The hyperreflective tissue beneath FCE, observed on B-scan OCT, presented as intensive choroidal flow signals on OCTA.Conclusions. FCE is not uncommon in patients with CSC. Multimodal imaging suggested that the aberrant choroidal circulation might be a contribution factor for leakage from the dysfunctional retinal pigment epithelium at the area of excavation.

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