Comparison of parameter agreement for characterization of corneal subbasal nerve plexus in the whorl-like region and central cornea using in vivo confocal microscopy

2020 ◽  
Author(s):  
Hua Yu ◽  
Shaozhen Zhao ◽  
Xiaowu Wang ◽  
Yuping Han ◽  
Juwei Zhao
Keyword(s):  
Confocal Microscopy ◽  
Nerve Plexus ◽  
In Vivo Confocal Microscopy ◽  
Central Cornea ◽  
Subbasal Nerve Plexus

Corneal Subbasal Nerve Plexus Evaluation by in Vivo Confocal Microscopy in Multiple Sclerosis: A Potential New Biomarker

2021 ◽  
pp. 1-8
Author(s):  
Diogo Fernandes ◽  
Maria Luís ◽  
Joana Cardigos ◽  
Catarina Xavier ◽  
Marta Alves ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Confocal Microscopy ◽  
Nerve Plexus ◽  
In Vivo Confocal Microscopy ◽  
Subbasal Nerve Plexus

Image Reconstruction of the Subbasal Nerve Plexus with In Vivo Confocal Microscopy

2011 ◽  
Vol 52 (9) ◽  
pp. 5022 ◽  
Author(s):  
Stephan Allgeier ◽  
Andrey Zhivov ◽  
Franz Eberle ◽  
Bernd Koehler ◽  
Susanne Maier ◽  
...  
Keyword(s):  
Image Reconstruction ◽  
Confocal Microscopy ◽  
Nerve Plexus ◽  
In Vivo Confocal Microscopy ◽  
Subbasal Nerve Plexus

scholarly journals An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eszter Szalai ◽  
Gabriella Szucs ◽  
Szilvia Szamosi ◽  
Zsuzsa Aszalos ◽  
Ildiko Afra ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Confocal Microscopy ◽  
Ocular Surface ◽  
Healthy Subjects ◽  
Ocular Surface Disease ◽  
Nerve Plexus ◽  
In Vivo Confocal Microscopy ◽  
Software Analysis ◽  
Subbasal Nerve Plexus

AbstractTo investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tomograph III, Heidelberg Engineering GmbH, Heidelberg, Germany) and ocular surface evaluation. Subbasal nerve plexus morphology was investigated using automated software analysis (ACCMetrics V3; University of Manchester, Manchester, UK). Keratocyte cell densities in the anterior stroma were significantly lower in patients with SSc compared to controls (P < 0.0001). In 7 SSc patients no keratocyte nuclei were identified in the anterior stroma and in most patients scattered hyperreflective punctate material were observed in the anterior stroma. Significantly lower subbasal nerve fiber parameters were found in patients with SSc compared to healthy subjects (P < 0.05). There were no significant correlations between the duration of SSc and any of the corneal cell density values. Tear break-up time values (4.82 ± 3.15 s) and Ocular Surface Disease Index scores (33.27 ± 30.11) were abnormal, Schirmer values (6.78 ± 5.82 mm) were borderline in SSc patients. In SSc, corneal morphological changes and accumulation of punctate material in the stroma was detected with confocal microscopy. Severe ocular surface disease was observed in SSc patients with significant impairment in subbasal nerve plexus morphology resembling peripheral neuropathy.

Corneal Sensitivity and Slit Scanning In Vivo Confocal Microscopy of the Subbasal Nerve Plexus of the Normal Central and Peripheral Human Cornea

Cornea ◽  
2009 ◽  
Vol 28 (7) ◽  
pp. 735-740 ◽  
Author(s):  
Dipika V Patel ◽  
Mitra Tavakoli ◽  
Jennifer P Craig ◽  
Nathan Efron ◽  
Charles N J McGhee
Keyword(s):  
Confocal Microscopy ◽  
Nerve Plexus ◽  
Human Cornea ◽  
In Vivo Confocal Microscopy ◽  
Corneal Sensitivity ◽  
Slit Scanning ◽  
Subbasal Nerve Plexus

In Vivo Confocal Microscopy Automated Morphometric Analysis of Corneal Subbasal Nerve Plexus in Patients With Dry Eye Treated With Different Sources of Homologous Serum Eye Drops

Cornea ◽  
2019 ◽  
Vol 38 (11) ◽  
pp. 1412-1417 ◽  
Author(s):  
Giuseppe Giannaccare ◽  
Marco Pellegrini ◽  
Federico Bernabei ◽  
Fabiana Moscardelli ◽  
Marina Buzzi ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Dry Eye ◽  
Morphometric Analysis ◽  
Nerve Plexus ◽  
Eye Drops ◽  
In Vivo Confocal Microscopy ◽  
Different Sources ◽  
Serum Eye Drops ◽  
Subbasal Nerve Plexus

scholarly journals Corneal subbasal nerve plexus changes in patients with episodic migraine: an in vivo confocal microscopy study

2019 ◽  
Vol Volume 12 ◽  
pp. 1489-1495 ◽  
Author(s):  
Feifei Shen ◽  
Xin Dong ◽  
Xin Zhou ◽  
Lanyun Yan ◽  
Qi Wan
Keyword(s):  
Confocal Microscopy ◽  
Microscopy Study ◽  
Episodic Migraine ◽  
Nerve Plexus ◽  
In Vivo Confocal Microscopy ◽  
Subbasal Nerve Plexus

Interocular Comparison by In Vivo Confocal Microscopy of the 2-Dimensional Architecture of the Normal Human Corneal Subbasal Nerve Plexus

Cornea ◽  
2012 ◽  
Vol 31 (12) ◽  
pp. 1376-1380 ◽  
Author(s):  
Stuti Misra ◽  
Jennifer P. Craig ◽  
Charles N. J. McGhee ◽  
Dipika V. Patel
Keyword(s):  
Confocal Microscopy ◽  
Nerve Plexus ◽  
In Vivo Confocal Microscopy ◽  
Normal Human ◽  
Subbasal Nerve Plexus

An in vivo confocal microscopy study of corneal changes in pseudoexfoliation syndrome

2018 ◽  
Vol 29 (5) ◽  
pp. 555-560 ◽  
Author(s):  
Luca Terracciano ◽  
Michela Cennamo ◽  
Eleonora Favuzza ◽  
Litasova Julia ◽  
Orsola Caporossi ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Anterior Segment ◽  
Senile Cataract ◽  
Nerve Plexus ◽  
Pseudoexfoliation Syndrome ◽  
Control Group ◽  
In Vivo Confocal Microscopy ◽  
Corneal Sensitivity ◽  
Corneal Layer

Purpose: To evaluate, through the in vivo confocal microscopy, the pathological changes of each corneal layer in eyes affected by pseudoexfoliation syndrome. Methods: We studied 40 eyes of 40 patients with diagnosis of unilateral senile cataract associated with pseudoexfoliation syndrome and 40 eyes of 40 control subjects with senile cataract without pseudoexfoliation syndrome. All patients underwent a complete ophthalmic examination including best corrected visual acuity, slit-lamp examination, corneal sensitivity measurement using a Cochet-Bonnet nylon thread esthesiometer, and anterior segment optical coherence tomography (Visante OCT, Carl Zeiss Meditec AG, Germany); in vivo confocal microscopy of corneal sections (endothelium, stroma, sub-basal nerve plexus, and superficial and basal epithelium) was performed with the ConfoScan 4.0 (Nidek, Japan). Results: In pseudoexfoliation syndrome group, the mean corneal sensitivity was 44.1 ± 1.3 mm and in the control group was 55.6 ± 4.7 mm. The corneas of the eyes with pseudoexfoliation syndrome were significantly less sensitive than those of control group eyes (p < 0.001). Pseudoexfoliation syndrome eyes had a lower nerve density and less nerve beadings and a higher degree of tortuosity in sub-basal plexus compared to the control group. The cell density of epithelial and endothelial layers was significantly lower in pseudoexfoliation syndrome eyes than controls. In 80% of pseudoexfoliation syndrome eyes, we found activated keratocytes and inflammatory cells in the anterior stroma. Conclusion: Our study demonstrates the morpho-structural corneal alterations in eyes affected by pseudoexfoliation syndrome, using corneal in vivo confocal microscopy as a non-invasive and high-reproducible technique to evaluate pathophysiology of each corneal layer; the sub-basal nerve plexus alterations are correlated with the lower corneal sensitivity.

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