Developmental Trajectories of Pediatric Obsessive–Compulsive Symptoms

2021 ◽  
Author(s):  
Anna K. Luke ◽  
Rachel Ankney ◽  
Emily P. Wilton ◽  
Theresa R. Gladstone ◽  
Kristoffer S. Berlin ◽  
...  
Keyword(s):  
Developmental Trajectories ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms

scholarly journals Obsessive–Compulsive Symptoms and Related Sex Differences in Brain Structure: An MRI Study in Dutch Twins

2013 ◽  
Vol 16 (2) ◽  
pp. 516-524 ◽  
Author(s):  
Anouk den Braber ◽  
Eco J.C. de Geus ◽  
Dorret I. Boomsma ◽  
Dennis van ‘t Ent
Keyword(s):  
Sex Differences ◽  
Developmental Trajectories ◽  
Gray Matter Volume ◽  
Middle Temporal Gyrus ◽  
Brain Anatomy ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Middle Temporal ◽  
Compulsive Disorder ◽  
The Right

Neuroimaging studies have indicated abnormalities in cortico-striato-thalamo-cortical circuits in obsessive–compulsive disorder patients, but results have not been consistent. Since there are significant sex differences in human brain anatomy and obsessive–compulsive symptomatology and its developmental trajectories tend to be distinct in males and females, we investigated whether sex is a potential source of heterogeneity in neuroimaging studies on obsessive–compulsive symptoms. We selected male and female twin pairs who were concordant for scoring either high or low for obsessive–compulsive symptoms and a group of discordant pairs where one twin scored high and the co-twin scored low. The design included 24 opposite-sex twin pairs. Magnetic resonance imaging scans of 31 males scoring high for obsessive–compulsive symptoms, 41 low-scoring males, 58 high-scoring females, and 73 low-scoring females were analyzed and the interaction of obsessive–compulsive symptoms by sex on gray matter volume was assessed using voxel-based morphometry. An obsessive–compulsive symptom by sex interaction was observed for the left middle temporal gyrus, the right middle temporal gyrus, and the right precuneus. These interactions acted to reduce or hide a main effect in our study and illustrate the importance of taking sex into account when investigating the neurobiology of obsessive–compulsive symptoms.

Are Anxiety and Obsessive-Compulsive Symptoms Related to Muscle Dysmorphia?

2009 ◽  
Vol 8 (2) ◽  
pp. 143-154 ◽  
Author(s):  
Christopher G. Chandler ◽  
W. Pitt Derryberry ◽  
Frederick G. Grieve ◽  
Phillip O. Pegg
Keyword(s):  
Muscle Dysmorphia ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms

Disentangling Doubt and Checking Behaviors and Examining Their Association With Obsessive Compulsive Symptoms

2021 ◽  
pp. 216770262199386
Author(s):  
Asher Y. Strauss ◽  
Isaac Fradkin ◽  
Jonathan D. Huppert
Keyword(s):  
Mouse Tracking ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Null Results ◽  
Unobtrusive Measure ◽  
Compulsive Checking ◽  
Tone Discrimination ◽  
Neutral Conditions ◽  
The Relationship

Experiencing doubt in an uncertain situation has been theorized to be an antecedent of compulsive checking. However, whether and when obsessive compulsive (OC) symptoms are associated with experiencing doubt and increased checking is unclear. In this study, we investigated the relationship between OC symptoms, the experience of doubt, and checking in a tone-discrimination task. Doubt was measured using mouse tracking, an indirect, unobtrusive measure. The results of two studies ( N = 119) showed that OC symptoms were associated with elevated experiences of doubt when uncertainty was low. However, OC symptoms were not associated with increased checking, but doubt was. Results highlight the utility of mouse-tracking measures to capture the tendency of individuals with OC symptoms to experience doubt even under neutral conditions. The unexpected null results concerning checking suggest some specific directions for research to determine the conditions under which doubt evolves into checking in obsessive compulsive disorder.

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