Inclusion complex formation of β-cyclodextrin and Naproxen: a study on exothermic complex formation by differential scanning calorimetry

2012 ◽  
Vol 77 (1-4) ◽  
pp. 269-277 ◽  
Author(s):  
Heather E. Grandelli ◽  
Bryce Stickle ◽  
Abby Whittington ◽  
Erdogan Kiran
Keyword(s):  
Differential Scanning Calorimetry ◽  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complex Formation ◽  
Scanning Calorimetry

scholarly journals Preparation and characterization of artemether inclusion complexes with hydroxypropyl-β-cyclodextrin

2017 ◽  
Vol 16 (10) ◽  
pp. 2359-2364
Author(s):  
Zwanden Sule Yahaya ◽  
Kenneth C. Ofokansi ◽  
Suzane T. Allagh ◽  
Pat G. Bhatia
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Dissolution Rate ◽  
Inclusion Complexes ◽  
In Vitro Dissolution ◽  
Phase Solubility ◽  
Inclusion Complex Formation ◽  
Scanning Calorimetry ◽  
Ft Ir

Purpose: To investigate experimentally the inclusion of artemether into the cavity of  hydroxypropyl-β-cyclodextrin and examine its effect on the solubility and dissolution rate of the drug.Methods: Inclusion complexes of artemether with hydroxypropyl-β-cyclodextrin of molar ratios 1:1, 1:2 and 1:3 were prepared using the kneading method. Phase solubility analysis and in vitro dissolution studies were utilized in evaluating the influence of inclusion complex formation on the solubility and dissolution rate of the drug. The complexes were characterized using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The inclusion complex containing equimolar concentrations of artemether and hydroxypropyl-β-cyclodextrin was then formulated into tablets via direct compression and  evaluated for various pharmaceutical characteristics including hardness, friability, absolute drug content and comparative in vitro dissolution profiles with some  commercially available brands of artemether.Results: The phase solubility diagram for the formed complexes in water at 37 oC indicated a linear curve soluble complex system (referred to as the AL system), and a stability constant (KC) value of 143 M-1. Evidence consistent with inclusion complex formation was obtained using FT-IR and DSC. The formulated inclusion complex tablets exhibited a higher rate of dissolution than the pure drug and commercial brands, showing 3.9-, 1.8- and 1.6-fold increases, respectively, over a period of 15 min.Conclusion: Inclusion complexation of artemether with hydroxypropyl-β-cyclodextrin is a promising approach to enhance the solubility and dissolution rate of the drug.Keywords: Artemether, 2-Hydroxypropyl-β-cyclodextrin, Dissolution, Solubility enhancement, Inclusion complex

Effect of starch-lipids inclusion complex formation on functional properties of flour in tandoori roti

2000 ◽  
Vol 69 (2) ◽  
pp. 129-133 ◽  
Author(s):  
Narpinder Singh ◽  
Kulwinder Kaur ◽  
Hardeep Singh ◽  
Harmeet Singh
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Functional Properties ◽  
Inclusion Complex Formation

Inclusion Complex Formation between a Novel Anionic Cyclophane and Cationic Aromatic Guests in Aqueous Solution

Heterocycles ◽  
1993 ◽  
Vol 36 (8) ◽  
pp. 1851 ◽  
Author(s):  
Kenji Koga ◽  
Muneharu Miyake ◽  
Makoto Kirisawa
Keyword(s):  
Aqueous Solution ◽  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complex Formation

Partially-methylated amyloses as effective hosts for inclusion complex formation with polymeric guests

2007 ◽  
pp. 1559 ◽  
Author(s):  
Toshiyuki Kida ◽  
Takashi Minabe ◽  
Shogo Okabe ◽  
Mitsuru Akashi
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complex Formation ◽  
Partially Methylated

Inclusion Complex Formation of 1,8-Dihydroxyanthraquinone with Cyclodextrins in Aqueous Solution and in Solid State

1988 ◽  
Vol 77 (6) ◽  
pp. 523-526 ◽  
Author(s):  
Giulietta Smulevich ◽  
Alessandro Feis ◽  
Giovanni Mazzi ◽  
Franco F. Vincieri
Keyword(s):  
Aqueous Solution ◽  
Solid State ◽  
Complex Formation ◽  
Inclusion Complex ◽  
Inclusion Complex Formation

Alkalinizing Water-Soluble Local Anesthetic Solutions by Addition of Cyclodextrin

1998 ◽  
Vol 23 (2) ◽  
pp. 176-181 ◽  
Author(s):  
Michio Miyoshi ◽  
Toshiaki Imoto ◽  
Yasutake Hiji
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Water Soluble ◽  
Spectral Change ◽  
Practical Application ◽  
Inclusion Complex Formation ◽  
Physiologic Saline ◽  
Form Inclusion Complex

Background and objectivesThe use of sodium bicarbonate for alkalinization of local anesthetics to improve their efficacy has some disadvantages including decreased stability of the solutions. The present study was performed to evaluate usefulness of cyclodextrins (CDs) in improving the solubility and stability of local anesthetic solutions at near physiologic pH without precipitation.MethodsSolubility of local anesthetics with or without CDs in physiologic saline was investigated by monitoring cloudiness or precipitate formation visually and by recording absorbance at 620 nm. Interaction of anesthetic and CD was also studied spectrophotometrically using spectral change of the drugs associated with the inclusion complex formation.ResultsCyclodextrins improved the solubility and stability of the four local anesthetics studied (dibucaine, tetracaine, bupivacaine, and lidocaine). In the neutral pH region, the effects of the CDs were more significant with dibucaine and tetracaine, which are more hydrophobic than the other two. A type of effective CD was different for each anesthetic depending partly on the tendency to form inclusion complex with local anesthetic. The local anesthetic solutions solubilized by CDs were found to remain clear for more than 72 hours without any visible precipitation or turbidity at neutral pHs.ConclusionsThe improved solubility of local anesthetics by adding CD may be caused by inclusion complex formation of CD with local anesthetics. This new preparation for the alkalinized water-soluble anesthetic solutions may be useful for practical application in the clinical setting, although this awaits further study.

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