AβP1-42 incorporation and channel formation in planar lipid membranes: the role of cholesterol and its oxidation products

2013 ◽  
Vol 45 (4) ◽  
pp. 369-381 ◽  
Author(s):  
Daniela Meleleo ◽  
Angela Galliani ◽  
Gabriella Notarachille
Keyword(s):  
Lipid Membranes ◽  
Oxidation Products ◽  
Channel Formation ◽  
Planar Lipid Membranes

Magainin 2 channel formation in planar lipid membranes: the role of lipid polar groups and ergosterol

2003 ◽  
Vol 32 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Enrico Gallucci ◽  
Daniela Meleleo ◽  
Silvia Micelli ◽  
Vittorio Picciarelli
Keyword(s):  
Lipid Membranes ◽  
Channel Formation ◽  
Polar Groups ◽  
Planar Lipid Membranes

scholarly journals Effect of Sterols on β-Amyloid Peptide (AβP 1–40) Channel Formation and their Properties in Planar Lipid Membranes

2004 ◽  
Vol 86 (4) ◽  
pp. 2231-2237 ◽  
Author(s):  
Silvia Micelli ◽  
Daniela Meleleo ◽  
Vittorio Picciarelli ◽  
Enrico Gallucci
Keyword(s):  
Lipid Membranes ◽  
Amyloid Peptide ◽  
Channel Formation ◽  
Β Amyloid ◽  
Planar Lipid Membranes ◽  
Β Amyloid Peptide

scholarly journals The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer

2021 ◽  
Vol 22 (12) ◽  
pp. 6183
Author(s):  
Delia Acevedo-León ◽  
Lidia Monzó-Beltrán ◽  
Segundo Ángel Gómez-Abril ◽  
Nuria Estañ-Capell ◽  
Natalia Camarasa-Lillo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Redox State ◽  
Reduced Glutathione ◽  
Redox Status ◽  
Oxidation Products ◽  
Interventional Study ◽  
Thiol Redox State ◽  
Thiol Redox ◽  
Glutathione Redox

The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to identify the mechanisms of ROS-induced carcinogenesis; however, the validation of OS byproducts as potential tumor markers (TMs) remains to be established. This interventional study included a total of 80 colorectal cancer (CRC) patients and 60 controls. By measuring reduced glutathione (GSH), its oxidized form (GSSG), and the glutathione redox state in terms of the GSSG/GSH ratio in the serum of CRC patients, we identified significant changes as compared to healthy subjects. These findings are compatible with the effectiveness of glutathione as a TM. The thiol redox state showed a significant increase towards oxidation in the CRC group and correlated significantly with both the tumor state and the clinical evolution. The sensitivity and specificity of serum glutathione levels are far above those of the classical TMs CEA and CA19.9. We conclude that the GSSG/GSH ratio is a simple assay which could be validated as a novel clinical TM for the diagnosis and monitoring of CRC.

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