Magainin 2 channel formation in planar lipid membranes: the role of lipid polar groups and ergosterol

2003 ◽  
Vol 32 (1) ◽  
pp. 22-32 ◽  
Author(s):  
Enrico Gallucci ◽  
Daniela Meleleo ◽  
Silvia Micelli ◽  
Vittorio Picciarelli
Keyword(s):  
Lipid Membranes ◽  
Channel Formation ◽  
Polar Groups ◽  
Planar Lipid Membranes

scholarly journals Effect of Sterols on β-Amyloid Peptide (AβP 1–40) Channel Formation and their Properties in Planar Lipid Membranes

2004 ◽  
Vol 86 (4) ◽  
pp. 2231-2237 ◽  
Author(s):  
Silvia Micelli ◽  
Daniela Meleleo ◽  
Vittorio Picciarelli ◽  
Enrico Gallucci
Keyword(s):  
Lipid Membranes ◽  
Amyloid Peptide ◽  
Channel Formation ◽  
Β Amyloid ◽  
Planar Lipid Membranes ◽  
Β Amyloid Peptide

scholarly journals Towards designing globular antimicrobial peptide mimics: role of polar functional groups in biomimetic ternary antimicrobial polymers

Soft Matter ◽  
2021 ◽  
Author(s):  
Garima Rani ◽  
Kenichi Kuroda ◽  
Satyavani Vemparala
Keyword(s):  
Molecular Dynamics ◽  
Antimicrobial Peptide ◽  
Bacterial Membrane ◽  
Simulation Data ◽  
Antimicrobial Polymers ◽  
Polar Groups ◽  
Methacrylate Polymers ◽  
Dynamics Simulations ◽  
Polar Functional Groups

Using atomistic molecular dynamics simulations, we study the interaction of ternary methacrylate polymers, composed of charged cationic, hydrophobic and neutral polar groups, with model bacterial membrane. Our simulation data shows...

scholarly journals Cholesterol provides nonsacrificial protection of membrane lipids from chemical damage at air–water interface

2018 ◽  
Vol 115 (13) ◽  
pp. 3255-3260 ◽  
Author(s):  
Xinxing Zhang ◽  
Kevin M. Barraza ◽  
J. L. Beauchamp
Keyword(s):  
Lipid Membranes ◽  
Membrane Lipids ◽  
Oh Radicals ◽  
Significant Finding ◽  
Water Interface ◽  
Unsaturated Lipids ◽  
Air Water Interface ◽  
Liquid Ordered ◽  
Ester Linkage

The role of cholesterol in bilayer and monolayer lipid membranes has been of great interest. On the biophysical front, cholesterol significantly increases the order of the lipid packing, lowers the membrane permeability, and maintains membrane fluidity by forming liquid-ordered–phase lipid rafts. However, direct observation of any influence on membrane chemistry related to these cholesterol-induced physical properties has been absent. Here we report that the addition of 30 mol % cholesterol to 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (POPG) monolayers at the air–water interface greatly reduces the oxidation and ester linkage cleavage chemistries initiated by potent chemicals such as OH radicals and HCl vapor, respectively. These results shed light on the indispensable chemoprotective function of cholesterol in lipid membranes. Another significant finding is that OH oxidation of unsaturated lipids generates Criegee intermediate, which is an important radical involved in many atmospheric processes.

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