Tl+ induces both cationic and transition pore permeability in the inner membrane of rat heart mitochondria

2013 ◽  
Vol 45 (6) ◽  
pp. 531-539 ◽  
Author(s):  
Sergey M. Korotkov ◽  
Vladimir P. Nesterov ◽  
Irina V. Brailovskaya ◽  
Viktor V. Furaev ◽  
Artemy V. Novozhilov
Keyword(s):  
Rat Heart ◽  
Heart Mitochondria ◽  
Inner Membrane ◽  
Rat Heart Mitochondria ◽  
Pore Permeability

Involvement of SH-groups during interaction of diazoxide with the inner membrane of rat heart mitochondria

2007 ◽  
Vol 415 (1) ◽  
pp. 206-210 ◽  
Author(s):  
S. M. Korotkov ◽  
V. P. Nesterov ◽  
L. V. Emel’yanova ◽  
N. N. Ryabchikov
Keyword(s):  
Rat Heart ◽  
Heart Mitochondria ◽  
Inner Membrane ◽  
Sh Groups ◽  
Rat Heart Mitochondria

scholarly journals Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria

1987 ◽  
Vol 245 (3) ◽  
pp. 915-918 ◽  
Author(s):  
M Crompton ◽  
A Costi ◽  
L Hayat
Keyword(s):  
Oxidative Stress ◽  
Rat Heart ◽  
Heart Mitochondria ◽  
Matrix Space ◽  
Inner Membrane ◽  
Membrane Pore ◽  
The Matrix ◽  
Rat Heart Mitochondria ◽  
And Oxidative Stress

Rat heart mitochondria became permeabilized to sucrose when incubated with 100 nmol of Ca2+/mg of protein in the presence of Pi. Ca2+ chelation with EGTA restored impermeability to sucrose, which became entrapped in the matrix space. t-Butylhydroperoxide markedly promoted permeabilization in the presence of Ca2+ but not in its absence, and Ca2+-plus-t-butylhydroperoxide-induced permeabilization was reversed by EGTA. The data suggest that Ca2+ and oxidative stress synergistically promote the reversible opening of an inner membrane pore.

scholarly journals Effects of pinacidil and calcium on succinate-energized rat heart mitochondria in the presence of rotenone

2019 ◽  
Vol 487 (4) ◽  
pp. 460-464
Author(s):  
S. M. Korotkov ◽  
I. V. Brailovskaya ◽  
V. P. Nesterov ◽  
S. I. Soroko
Keyword(s):  
Rat Heart ◽  
Mitochondrial Permeability Transition Pore ◽  
Mitochondrial Permeability Transition ◽  
Ischemia Reperfusion ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Heart Mitochondria ◽  
Inner Membrane ◽  
Muscle Ischemia ◽  
Rat Heart Mitochondria

The effect of pinacidil was studied on calcium-loaded rat heart mitochondria (RHM) in the presence of succinate and rotenone. In experiments with pinacidil, the swelling of these mitochondria increased in media with NH4NO3 or K‑acetate, but the inner membrane potential DΨmito and state 3 or 2,4-dinitrophenol-uncoupled respiration of these organelles were decreased due to opening of the mitochondrial permeability transition pore in the inner membrane. These effects were inhibited by cyclosporin A and ADP. It was concluded that the protective effect of pinacidil in the cardiac muscle ischemia/reperfusion may be associated with stimulation mitochondrial swelling and a decrease in RHM calcium overload resulted in a decrease in DΨmito due to the soft uncoupling pinacidil effect.

Sign in / Sign up

Export Citation Format

Share Document