Latinas/os were present in the American South long before the founding of the United States of America, yet knowledge about their southern communities in different places and time periods is deeply uneven. In fact, regional themes important throughout the South clarify the dynamics that shaped Latinas/os’ lives, especially race, ethnicity, and the colorline; work and labor; and migration and immigration. Ideas about racial difference, in particular, reflected specifics of place, and intersections of local, regional, and international endeavors and movements of people and resources. Accordingly, Latinas/os’ position and treatment varied across the South. They first worked in agricultural fields picking cotton, oranges, and harvesting tobacco, then in a variety of industries, especially poultry and swine processing and packing. The late 20th century saw the rapid growth of Latinas/os in southern states due to changing migration and immigration patterns that moved from traditional states of reception to new destinations in rural, suburban, and urban locales with limited histories with Latinas/os or with substantial numbers of immigrants in general.