Numerical validation and properties of a rapid binding approximation of a target-mediated drug disposition pharmacokinetic model

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-009-9118-8 ◽

2009 ◽

Vol 36 (3) ◽

pp. 199-219 ◽

Author(s):

Anshu Marathe ◽

Wojciech Krzyzanski ◽

Donald E. Mager

Keyword(s):

Pharmacokinetic Model ◽

Drug Disposition ◽

Numerical Validation ◽

Target Mediated Drug Disposition ◽

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A Target‐Mediated Drug Disposition Population Pharmacokinetic Model of GC1118, a Novel Anti‐EGFR Antibody, in Patients with Solid Tumors

Clinical and Translational Science ◽

10.1111/cts.12963 ◽

2020 ◽

Author(s):

Tae Kyu Chung ◽

Hyun A Lee ◽

Sang‐In Park ◽

Do‐Youn Oh ◽

Keun‐Wook Lee ◽

...

Keyword(s):

Solid Tumors ◽

Population Pharmacokinetic Model ◽

Pharmacokinetic Model ◽

Drug Disposition ◽

Population Pharmacokinetic ◽

Target Mediated Drug Disposition ◽

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Impact of dose selection on parameter estimation using a rapid binding approximation model of target-mediated drug disposition

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-010-9190-0 ◽

2010 ◽

Vol 38 (2) ◽

pp. 223-235 ◽

Author(s):

Anshu Marathe ◽

Scott Van Wart ◽

Donald E. Mager

Keyword(s):

Parameter Estimation ◽

Drug Disposition ◽

Approximation Model ◽

Dose Selection ◽

Target Mediated Drug Disposition ◽

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Methods of solving rapid binding target-mediated drug disposition model for two drugs competing for the same receptor

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-012-9267-z ◽

2012 ◽

Vol 39 (5) ◽

pp. 543-560 ◽

Author(s):

Xiaoyu Yan ◽

Yang Chen ◽

Wojciech Krzyzanski

Keyword(s):

Drug Disposition ◽

Target Mediated Drug Disposition ◽

Disposition Model ◽

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P221 - Understanding the pharmacokinetic nonlinearity of tabalumab by incorporating target-mediated drug disposition in a physiologically-based pharmacokinetic model

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2020.04.222 ◽

2020 ◽

Vol 35 (1) ◽

pp. S89-S90

Author(s):

Lian Zhou ◽

Bing Han ◽

David Radtke ◽

Jennifer Witcher

Keyword(s):

Pharmacokinetic Model ◽

Drug Disposition ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Target Mediated Drug Disposition ◽

Physiologically Based

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Quasi-Equilibrium Pharmacokinetic Model for Drugs Exhibiting Target-Mediated Drug Disposition

Pharmaceutical Research ◽

10.1007/s11095-005-6650-0 ◽

2005 ◽

Vol 22 (10) ◽

pp. 1589-1596 ◽

Author(s):

Donald E. Mager ◽

Wojciech Krzyzanski

Keyword(s):

Pharmacokinetic Model ◽

Drug Disposition ◽

Quasi Equilibrium ◽

Target Mediated Drug Disposition

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Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-014-9372-2 ◽

2014 ◽

Vol 41 (4) ◽

pp. 375-387 ◽

Author(s):

Yanguang Cao ◽

William J. Jusko

Keyword(s):

Monoclonal Antibodies ◽

Pharmacokinetic Model ◽

Drug Disposition ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Target Mediated Drug Disposition ◽

Physiologically Based

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Estimating drug potency in the competitive target mediated drug disposition (TMDD) system when the endogenous ligand is included.

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-020-09734-9 ◽

2021 ◽

Author(s):

Begum Alaybeyoglu ◽

Ho Wa (Jacky) Cheng ◽

Kshama A. Doshi ◽

Vishruti Makani ◽

Andrew M. Stein

Keyword(s):

Drug Disposition ◽

Endogenous Ligand ◽

Drug Potency ◽

Target Mediated Drug Disposition

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Target-mediated drug disposition model for drugs with two binding sites that bind to a target with one binding site

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-017-9533-1 ◽

2017 ◽

Vol 44 (5) ◽

pp. 463-475 ◽

Author(s):

Leonid Gibiansky ◽

Ekaterina Gibiansky

Keyword(s):

Binding Site ◽

Binding Sites ◽

Drug Disposition ◽

Target Mediated Drug Disposition ◽

Disposition Model

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Prediction of Drug Disposition in Diabetic Patients by Means of a Physiologically Based Pharmacokinetic Model

Clinical Pharmacokinetics ◽

10.1007/s40262-014-0192-8 ◽

2014 ◽

Vol 54 (2) ◽

pp. 179-193 ◽

Author(s):

Jia Li ◽

Hai-fang Guo ◽

Can Liu ◽

Zeyu Zhong ◽

Li Liu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Drug Disposition ◽

Diabetic Patients ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Target‐Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12369 ◽

2019 ◽

Vol 8 (3) ◽

pp. 177-187 ◽

Author(s):

Johannes Schropp ◽

Antari Khot ◽

Dhaval K. Shah ◽

Gilbert Koch

Keyword(s):

Drug Disposition ◽

Bispecific Antibodies ◽

Optimal Dosing ◽

Target Mediated Drug Disposition ◽

Dosing Strategy ◽

Disposition Model

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