Effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by efonidipine

2012 ◽  
Vol 39 (1) ◽  
pp. 99-108 ◽  
Author(s):  
Cheng Li ◽  
Dong-Hyun Choi ◽  
Jun-Shik Choi
Keyword(s):  
Pharmacokinetics And Pharmacodynamics ◽  
P Glycoprotein ◽  
Glycoprotein Inhibition

Role of P-Glycoprotein Inhibition for Drug Interactions

2007 ◽  
Vol 46 (12) ◽  
pp. 1039-1049 ◽  
Author(s):  
Sonja Eberl ◽  
Bertold Renner ◽  
Antje Neubert ◽  
Mareike Reisig ◽  
Iouri Bachmakov ◽  
...  
Keyword(s):  
Drug Interactions ◽  
P Glycoprotein ◽  
Glycoprotein Inhibition

scholarly journals Multidrug resistance gene (MDR1) - marker of therapeutic resistance and severity of disease

2009 ◽  
Vol 7 (3) ◽  
pp. 9-13
Author(s):  
Z A Mironova ◽  
V I Trofimov ◽  
M A Simakova ◽  
E D Iantchina ◽  
M V Dubina
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Therapeutic Resistance ◽  
Inadequate Response ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Multidrug Resistance Gene ◽  
Severity Of Disease ◽  
P Glycoprotein ◽  
Genes Expression

Genes polymorphism is known to be one of the causes of the inadequate response to drugs or drugs resistance. In the most of cases drugs influence depends on interaction of several products of genes expression, which influence on drugs pharmacokinetics and pharmacodynamics. Present article concerns the review of publications and results of original investigations concerning the multidrug resistance gene (MDRl) expression associations with P-glycoprotein-170 (Pgp-170) expression in different diseases and the role of Pgp-170 in distribution of drugs in tissues.

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