Effects of myricetin on the bioavailability of doxorubicin for oral drug delivery in Rats: Possible role of CYP3A4 and P-glycoprotein inhibition by myricetin

: With a 2030 projection of 23.6 million deaths per year the prevalence and severity of cardiovascular disease is at an astounding high. Thus, a definitive need for the identification of novel compounds with potential to prevent or treat the disease and associated states. Moreover, there is also an ever-increasing need for drug delivery systems (DDS) that cope with poor and ranging physiochemical properties of therapeutic compounds to achieve clinical effect. The usage of resveratrol (RES) is a growing area of interest with innumerate pieces of research evidencing the drug’s efficacy. This drug is however marred, its notably poor physiochemical properties (namely poor water solubility) limits its use for oral drug delivery. RES analogues however, potentially possess superior physiochemical characteristics offering a remedy for the aforementioned drawback. However, particulate based DDS are equally able to offer property amelioration and targeting. This review offers an extensive examination into the role of RES as a potential cardio protective agent. The prevalence and suitability of associated analogues and the role of nanotechnology in overcoming physicochemical boundaries, particularly through the development of nanoparticulate formulations, will be discussed in detail.

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Overcoming poor permeability – the role of prodrugs for oral drug delivery

Drug Discovery Today Technologies ◽

10.1016/j.ddtec.2012.04.002 ◽

2012 ◽

Vol 9 (2) ◽

pp. e121-e130 ◽

Cited By ~ 12

Author(s):

Hans Maag

Keyword(s):

Drug Delivery ◽

Oral Drug Delivery ◽

Oral Drug

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Role of plasticizer in membrane coated extended release oral drug delivery system

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2017.12.020 ◽

2018 ◽

Vol 44 ◽

pp. 231-243 ◽

Cited By ~ 7

Author(s):

Pinak Khatri ◽

Dipen Desai ◽

Namdev Shelke ◽

Tamara Minko

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Extended Release ◽

Oral Drug Delivery ◽

Oral Drug ◽

Oral Drug Delivery System

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Role of Cyclodextrins in Improving Oral Drug Delivery

American Journal of Drug Delivery ◽

10.2165/00137696-200402040-00006 ◽

2004 ◽

Vol 2 (4) ◽

pp. 261-275 ◽

Cited By ~ 181

Author(s):

Thorsteinn Loftsson ◽

Marcus E Brewster ◽

M??r M??sson

Keyword(s):

Drug Delivery ◽

Oral Drug Delivery ◽

Oral Drug

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Transdermal drug delivery an emerging approach for antipsychotics

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i4.3200 ◽

2020 ◽

Vol 11 (4) ◽

pp. 5615-5625

Author(s):

Akash Tekawade ◽

Tanaji Nandgude

Keyword(s):

Drug Delivery ◽

Delivery System ◽

Transdermal Delivery ◽

Transdermal Drug Delivery ◽

Oral Drug Delivery ◽

Skin Penetration ◽

Barrier Properties ◽

Oral Drug ◽

Transdermal Drug Delivery System

Transdermal drug delivery system is one of the leading technology which gives extensive benefits compared to other dosage forms. In the case of drugs having a first-pass metabolism problem, small doses of drugs can be delivered. Oral drug delivery is associated with several problems like pain interrelated with the use of injections,needles, and the researchers mainly focus on the development of the transdermal route. The aim is to provide a rationale for improvement of the transdermal system of antipsychotics by highlighting the antipsychotic formulation and safely delivering medications across the skin.The present review emphasis on the latest advances in a transdermal delivery system which acts as a platform for effective transdermal delivery of antipsychotic. By using this technique, the pharmacotherapy of patients who have psychosis can be improved. There are numeral physical methods, and the skin penetration enhancement techniques have been developed that helps in delivering drugs through the skin.This technique helps to alter the barrier properties of skin and improves the penetration of the drug.It majorly highlights the possible role of microneedle in the transdermal system and acts as a different carrier in delivering several therapeutic agents effectively. This article summarizes thenovel transdermal delivery approaches, advantages, and the choice of antipsychotropic drugs.

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