Dose distribution verification in intraoperative radiation therapy using an N-isopropyl acrylamide-based polymer gel dosimeter

2020 ◽  
Vol 324 (2) ◽  
pp. 481-488
Author(s):  
Seyed Mohammad Mahdi Abtahi ◽  
Roghayeh Kargar Shaker Langaroodi ◽  
Mohammad Esmail Akbari
Author(s):  
S F Ghoreishi ◽  
J Beik ◽  
I Shiri ◽  
K Kh Keshavarzi ◽  
S R M Mahdavi

Background:Currently, the potential application of gold nanoparticles (AuNPs) to increase the efficiency of radiation therapy has been widely investigated. However, lack of an appropriate method to estimate the dose distribution in a nanoparticle-laden tissue limits the applicability of nanoparticles in radiotherapy clinics. Polymer gel dosimetry provides an accurate and precise system that facilitates the measurement of dose distribution in full three dimensions.Objective: In this study, the effect of radiation dose enhancement of AuNPs was assessed through gel dosimetry analysis.Material and Methods: For this purpose, AuNPs were integrated in MAGIC_f polymer gel dosimeter and irradiated by 6 Mv X-ray beam. The irradiated gel was then evaluated through two modalities of magnetic resonance imaging (MRI) and optical computed tomography (OCT).Result: MRI and OCT scanning of MAGIC_f gels containing 0.1 mM AuNPs demonstrated dose enhancements of 7.8% and 6.8%, respectively.Conclusion: Polymer gel dosimetry has the potential to provide a new platform for the investigation and optimization of the applicability of nanoparticles in radiation therapy.


2011 ◽  
Vol 59 (1) ◽  
pp. 169-175 ◽  
Author(s):  
Yu Ra Cho ◽  
Hyung Wook Park ◽  
Ae Ran Kim ◽  
Chae hee Park ◽  
Ji Hye Bong ◽  
...  

2019 ◽  
Vol 57 ◽  
pp. 72-79 ◽  
Author(s):  
Yusuke Watanabe ◽  
Shinya Mizukami ◽  
Kou Eguchi ◽  
Takuya Maeyama ◽  
Shin-ichiro Hayashi ◽  
...  

RADIOISOTOPES ◽  
2008 ◽  
Vol 57 (3) ◽  
pp. 183-188
Author(s):  
Kiyofumi HANEDA ◽  
Hiroki OKUDO ◽  
Yusuke TSUNEI ◽  
Munenori YOSHIOKA ◽  
Shin-ichiro HAYASHI ◽  
...  

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