scholarly journals Effect of Gold Nanoparticles on Dose Enhancement of 6 MV X-ray in MAGIC_f Polymer Gel Dosimeter

Author(s):  
S F Ghoreishi ◽  
J Beik ◽  
I Shiri ◽  
K Kh Keshavarzi ◽  
S R M Mahdavi

Background:Currently, the potential application of gold nanoparticles (AuNPs) to increase the efficiency of radiation therapy has been widely investigated. However, lack of an appropriate method to estimate the dose distribution in a nanoparticle-laden tissue limits the applicability of nanoparticles in radiotherapy clinics. Polymer gel dosimetry provides an accurate and precise system that facilitates the measurement of dose distribution in full three dimensions.Objective: In this study, the effect of radiation dose enhancement of AuNPs was assessed through gel dosimetry analysis.Material and Methods: For this purpose, AuNPs were integrated in MAGIC_f polymer gel dosimeter and irradiated by 6 Mv X-ray beam. The irradiated gel was then evaluated through two modalities of magnetic resonance imaging (MRI) and optical computed tomography (OCT).Result: MRI and OCT scanning of MAGIC_f gels containing 0.1 mM AuNPs demonstrated dose enhancements of 7.8% and 6.8%, respectively.Conclusion: Polymer gel dosimetry has the potential to provide a new platform for the investigation and optimization of the applicability of nanoparticles in radiation therapy.

2019 ◽  
Vol 75 (5) ◽  
pp. 415-423
Author(s):  
Seung Young Ko ◽  
Soo-Il Kwon ◽  
Junchul Chun ◽  
Hyun Soo Shin ◽  
Sei Kyung Chang ◽  
...  

2011 ◽  
Vol 38 (6Part13) ◽  
pp. 3531-3531
Author(s):  
S Kwon ◽  
Y Cho ◽  
K Cho ◽  
S Lee ◽  
Y Ji ◽  
...  

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