Natriuretic peptide receptor-C activation attenuates angiotensin II-induced enhanced oxidative stress and hyperproliferation of aortic vascular smooth muscle cells

2018 ◽  
Vol 448 (1-2) ◽  
pp. 77-89 ◽  
Author(s):  
Padma Madiraju ◽  
Ekhtear Hossain ◽  
Madhu B. Anand-Srivastava
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Natriuretic Peptide ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Natriuretic Peptide Receptor ◽  
Peptide Receptor

Blackberry, raspberry and black raspberry polyphenol extracts attenuate angiotensin II-induced senescence in vascular smooth muscle cells

2016 ◽  
Vol 7 (10) ◽  
pp. 4175-4187 ◽  
Author(s):  
Rafaela G. Feresin ◽  
Jingwen Huang ◽  
DawnKylee S. Klarich ◽  
Yitong Zhao ◽  
Shirin Pourafshar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Black Raspberry

Blackberry, raspberry and black raspberry polyphenols reduce angiotensin II-induced oxidative stress and senescence of vascular smooth muscle cells.

Hydrogen peroxide mediates a transient vasorelaxation with tempol during oxidative stress

2007 ◽  
Vol 293 (4) ◽  
pp. H2085-H2092 ◽  
Author(s):  
Yifan Chen ◽  
Adam Pearlman ◽  
Zaiming Luo ◽  
Christopher S. Wilcox
Keyword(s):  
Oxidative Stress ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Blood Vessels ◽  
Vascular Smooth Muscle Cells ◽  
Prolonged Exposure ◽  
Muscle Cells ◽  
Mesenteric Arteries

Tempol catalyzes the formation of H2O2 from superoxide and relaxes blood vessels. We tested the hypothesis that the generation of H2O2 by tempol in vascular smooth muscle cells during oxidative stress contributes to the vasorelaxation. Tempol and nitroblue tetrazolium (NBT) both metabolize superoxide in vascular smooth muscle cells, but only tempol generates H2O2. Rat pressurized mesenteric arteries were exposed for 20 min to the thromboxane-prostanoid receptor agonist, U-46619, or norepinephrine. During U-46619, tempol caused a transient dilation (22 ± 2%), whereas NBT was ineffective (2 ± 1%), and neither dilated vessels constricted with norepinephrine, which does not cause vascular oxidative stress. Neither endothelium removal nor blockade of K+ channels with 40 mM KCl affected the tempol-induced dilation, but catalase blunted the tempol dilation by 53 ± 7%. Tempol, but not NBT, increased H2O2 in rat mesenteric vessels detected with dichlorofluorescein. To test physiological relevance in vivo, topical application of tempol caused a transient dilation (184 ± 20%) of mouse cremaster arterioles exposed to angiotensin II for 30 min, which was not seen with NBT (9 ± 4%). The vasodilation to tempol was reduced by 68 ± 6% by catalase. We conclude that the transient relaxation of blood vessels by tempol after prolonged exposure to U-46619 or angiotensin II is mediated in part via production of H2O2 and is largely independent of the endothelium and potassium channels.

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