Primary anti-proliferative activity evaluation of 1-(quinolizidin-1’-yl)methyl- and 1-( $$\omega $$ -tert-amino)alkyl-substituted 2-phenyl-, 2-benzyl- and 2-[(benzotriazol-1/2-yl)methyl]benzimidazoles on human cancer cell lines

2013 ◽  
Vol 17 (3) ◽  
pp. 409-419 ◽  
Author(s):  
Michele Tonelli ◽  
Bruno Tasso ◽  
Lorenzo Mina ◽  
Giuseppe Paglietti ◽  
Vito Boido ◽  
...  
2008 ◽  
Vol 16 (10) ◽  
pp. 5570-5583 ◽  
Author(s):  
Stefanie Libnow ◽  
Karen Methling ◽  
Martin Hein ◽  
Dirk Michalik ◽  
Manuela Harms ◽  
...  

2018 ◽  
Vol 54 (2C) ◽  
pp. 502
Author(s):  
Le Duc Anh

Two new conjugates of murrayafoline A with zerumbone and artemisinin 3, 11 wereprepared by N-alkylation, in which, compound 3 was synthesized from two consecutive Nalkylationreactions. Their cytotoxicity was evaluated on four human cancer cell lines Hep-G2,LU, RD and Fl. The result showed that both compounds exhibited no activity against the testedcell lines.


2015 ◽  
Vol 165 (11-12) ◽  
pp. 258-261 ◽  
Author(s):  
Christian Busch ◽  
Seema Noor ◽  
Christian Leischner ◽  
Markus Burkard ◽  
Ulrich M. Lauer ◽  
...  

2015 ◽  
Vol 49 (3) ◽  
pp. 253-268 ◽  
Author(s):  
P. Banerjee ◽  
P. Majumder ◽  
S. Halder ◽  
M. G. B. Drew ◽  
S. Bhattacharya ◽  
...  

2018 ◽  
Vol 42 (11) ◽  
pp. 9126-9139 ◽  
Author(s):  
Kuheli Das ◽  
Belete B. Beyene ◽  
Amitabha Datta ◽  
Eugenio Garribba ◽  
Catarina Roma-Rodrigues ◽  
...  

The cytotoxicity and antiproliferative activity are carried out along with EPR and redox interpretation.


2019 ◽  
Vol 72 (5-7) ◽  
pp. 920-940 ◽  
Author(s):  
Kuheli Das ◽  
Amitabha Datta ◽  
Chiara Massera ◽  
Catarina Roma-Rodrigues ◽  
Mariana Barroso ◽  
...  

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Worku Dinku ◽  
Johan Isaksson ◽  
Fredrik Garnås Rylandsholm ◽  
Petr Bouř ◽  
Eva Brichtová ◽  
...  

Marine Drugs ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 76 ◽  
Author(s):  
Bo-Rong Peng ◽  
Kuei-Hung Lai ◽  
You-Ying Chen ◽  
Jui-Hsin Su ◽  
Yusheng M. Huang ◽  
...  

In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A–D (1– 4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1–7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1–7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.


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