Structural aspects of a trimetallic CuII derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines

2019 ◽  
Vol 72 (5-7) ◽  
pp. 920-940 ◽  
Author(s):  
Kuheli Das ◽  
Amitabha Datta ◽  
Chiara Massera ◽  
Catarina Roma-Rodrigues ◽  
Mariana Barroso ◽  
...  
2008 ◽  
Vol 16 (10) ◽  
pp. 5570-5583 ◽  
Author(s):  
Stefanie Libnow ◽  
Karen Methling ◽  
Martin Hein ◽  
Dirk Michalik ◽  
Manuela Harms ◽  
...  

2015 ◽  
Vol 165 (11-12) ◽  
pp. 258-261 ◽  
Author(s):  
Christian Busch ◽  
Seema Noor ◽  
Christian Leischner ◽  
Markus Burkard ◽  
Ulrich M. Lauer ◽  
...  

2018 ◽  
Vol 42 (11) ◽  
pp. 9126-9139 ◽  
Author(s):  
Kuheli Das ◽  
Belete B. Beyene ◽  
Amitabha Datta ◽  
Eugenio Garribba ◽  
Catarina Roma-Rodrigues ◽  
...  

The cytotoxicity and antiproliferative activity are carried out along with EPR and redox interpretation.


Marine Drugs ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 76 ◽  
Author(s):  
Bo-Rong Peng ◽  
Kuei-Hung Lai ◽  
You-Ying Chen ◽  
Jui-Hsin Su ◽  
Yusheng M. Huang ◽  
...  

In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A–D (1– 4), along with three known compounds, 12α-acetoxy-22-hydroxy-24-methyl-24-oxoscalar-16-en- 25-al (5), felixin F (6), and 24-methyl-12,24,25-trioxoscalar-16-en-22-oic acid (7) were isolated from the sponge Lendenfeldia sp. The structures of scalaranes 1–7 were elucidated on the basis of spectroscopic analysis. Scalaranes 1–7 were further evaluated for their cytotoxicity toward a series of human cancer cell lines and the results suggested that 5 and 7 dominated in the anti- proliferative activity of the extract. The 18-aldehyde functionality was found to play a key role in their activity.


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