scholarly journals Multi-scale mechanism of antiviral drug-alike phytoligands from Ayurveda in managing COVID-19 and associated metabolic comorbidities: insights from network pharmacology

2022 ◽  
Author(s):  
Neha Choudhary ◽  
Vikram Singh
Keyword(s):  
Antiviral Drug ◽  
Network Pharmacology ◽  
Multi Scale ◽  
Metabolic Comorbidities

scholarly journals Deciphering the multi-scale mechanisms of Tephrosia purpurea against polycystic ovarian syndrome (PCOS) and its major psychiatric comorbidities: studies from network-pharmacological perspective

2019 ◽  
Author(s):  
Neha Choudhary ◽  
Shilpa Choudhary ◽  
Vikram Singh
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Endocrine System ◽  
Network Pharmacology ◽  
Modular Architecture ◽  
High Confidence ◽  
Protein Targets ◽  
Multi Scale ◽  
Tephrosia Purpurea ◽  
Regulatory Potential ◽  
Ovarian Syndrome

AbstractTephrosia purpurea (T. purpurea), a plant belonging to Fabaceae (pea) family, is a well-known Ayurvedic herb and is commonly known as Sarapunkha in traditional Indian medicinal system. Described as “Sarwa wranvishapaka”, i.e. having capability to heal all types of wounds, it is particularly recognized for its usage in splenomegaly. Towards exploring the comprehensive effects of T. purpurea against polycystic ovarian syndrome (PCOS), its phytochemicals were extensively reviewed and their network pharmacology evaluation is carried out in this study. The complex regulatory potential of its 76 phytochemicals (PCs) against PCOS are enquired by developing and analyzing high confidence tripartite networks of protein targets of each phytochemical at both pathway and disease association scales. We also developed a high-confidence human PPI sub-network specific to PCOS, explored its modular architecture and probed the drug-like phytochemicals (DPCs) having multi-module regulatory potential. The proteins belonging to endocrine system were identified as major targets of the PCs. The study reports 30 DPCs based on ADMET and drug-like properties. Multi-targeting and synergistic capacities of the 12 DPCs against 10 protein targets were identified and evaluated using molecular docking and interaction analyses. The study concludes by highlighting a couple of DPCs as potential sources of PCOS regulators.

A Proposal of 3D Feature based on Occupancy of Point Cloud in Multi-Scale Shell Region

2016 ◽  
Vol 136 (8) ◽  
pp. 1078-1084
Author(s):  
Shoichi Takei ◽  
Shuichi Akizuki ◽  
Manabu Hashimoto
Keyword(s):  
Point Cloud ◽  
Multi Scale ◽  
Feature Based ◽  
Shell Region

RECONSTRUCTION OF NON-STATIONARY COMPLEX SPATIAL STRUCTURES BY A NOVEL FILTER-BASED MULTI SCALE MPS ALGORITHM

2014 ◽  
Vol 2014 (2) ◽  
pp. 60-71
Author(s):  
Peyman Mohammadmoradi ◽  
◽  
Mohammad Rasaeii ◽  
Keyword(s):  
Spatial Structures ◽  
Multi Scale

Erratum: “Primal Macro-Projective Integration Method for Multi-Scale Plasma Simulation” [Plasma Fusion Res. 3, 021 (2008)]

2009 ◽  
Vol 4 ◽  
pp. 056-056 ◽  
Author(s):  
Miloš M. ŠKORIĆ ◽  
Aleksandra MALUCKOV ◽  
Seiji ISHIGURO
Keyword(s):  
Integration Method ◽  
Plasma Simulation ◽  
Multi Scale ◽  
Plasma Fusion

ECG Classification with Multi-Scale Deep Features Based on Adaptive Beat-Segmentation

2020 ◽  
Vol E103.B (12) ◽  
pp. 1403-1410
Author(s):  
Huan SUN ◽  
Yuchun GUO ◽  
Yishuai CHEN ◽  
Bin CHEN
Keyword(s):  
Multi Scale
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