scholarly journals Deciphering the multi-scale mechanisms of Tephrosia purpurea against polycystic ovarian syndrome (PCOS) and its major psychiatric comorbidities: studies from network-pharmacological perspective

2019 ◽  
Author(s):  
Neha Choudhary ◽  
Shilpa Choudhary ◽  
Vikram Singh
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Endocrine System ◽  
Network Pharmacology ◽  
Modular Architecture ◽  
High Confidence ◽  
Protein Targets ◽  
Multi Scale ◽  
Tephrosia Purpurea ◽  
Regulatory Potential ◽  
Ovarian Syndrome

AbstractTephrosia purpurea (T. purpurea), a plant belonging to Fabaceae (pea) family, is a well-known Ayurvedic herb and is commonly known as Sarapunkha in traditional Indian medicinal system. Described as “Sarwa wranvishapaka”, i.e. having capability to heal all types of wounds, it is particularly recognized for its usage in splenomegaly. Towards exploring the comprehensive effects of T. purpurea against polycystic ovarian syndrome (PCOS), its phytochemicals were extensively reviewed and their network pharmacology evaluation is carried out in this study. The complex regulatory potential of its 76 phytochemicals (PCs) against PCOS are enquired by developing and analyzing high confidence tripartite networks of protein targets of each phytochemical at both pathway and disease association scales. We also developed a high-confidence human PPI sub-network specific to PCOS, explored its modular architecture and probed the drug-like phytochemicals (DPCs) having multi-module regulatory potential. The proteins belonging to endocrine system were identified as major targets of the PCs. The study reports 30 DPCs based on ADMET and drug-like properties. Multi-targeting and synergistic capacities of the 12 DPCs against 10 protein targets were identified and evaluated using molecular docking and interaction analyses. The study concludes by highlighting a couple of DPCs as potential sources of PCOS regulators.

Endocrine

2019 ◽  
pp. 217-238
Author(s):  
Tanya M. Monaghan ◽  
James D. Thomas
Keyword(s):  
Cushing’S Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Endocrine System ◽  
Addison’S Disease ◽  
Cushing's Syndrome ◽  
Addison's Disease ◽  
Turner's Syndrome ◽  
Klinefelter’S Syndrome ◽  
Klinefelter's Syndrome ◽  
Ovarian Syndrome

This chapter concerns the endocrine system, and covers goitre, hyperthyroidism, Graves’s disease, hypothyroidism, acromegaly, Cushing’s syndrome, Addison’s disease, hypopituitarism, polycystic ovarian syndrome, Turner’s syndrome, and Klinefelter’s syndrome.

scholarly journals Short Review on Polycystic Ovarian Syndrome

2017 ◽  
Vol 19 (1) ◽  
pp. 49-53
Author(s):  
Rabia Farooq
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Endocrine System ◽  
Short Review ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
The World ◽  
Long Time ◽  
System Disorder ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is a metabolic disease and a common endocrine system disorder among women of reproductive age. Infrequent or prolonged menstrual periods, excess hair growth, acne, and obesity can occur in women with PCOS. Early diagnosis and treatment along with weight loss may reduce the risk of long-term complications. Now a days PCOS is also the cause of infertility. India is PCOS capital of the world. PCOS management is necessary to reduce its long time complications.J MEDICINE Jan 2018; 19 (1) : 49-53

scholarly journals Piper longum: A review of its phytochemicals and their network pharmacological evaluation

2017 ◽  
Author(s):  
Neha Choudhary ◽  
Vikram Singh
Keyword(s):  
Drug Targets ◽  
Network Pharmacology ◽  
High Confidence ◽  
Protein Targets ◽  
Piper Longum ◽  
Protein Target ◽  
The Common ◽  
Novel Drug ◽  
Novel Drug Targets

AbstractPiper longum L. (P. longum, also called as long pepper) is one of the common culinary herb and has been extensively used as an important constituent of various indigenous medicines, specifically in traditional Indian medicinal system known as Ayurveda. Towards obtaining a global regulatory framework of P. longum’s constituents, in this work we first reviewed phytochemicals present in this herb and then studied their pharmacological and medicinal features using network pharmacology approach. We developed high-confidence level tripartite networks consisting of phytochemicals – protein targets – disease association and explain the role of its phytochemicals to various chronic diseases. 7 drug-like phytochemicals in this herb were found as the potential regulators of 5 FDA approved drug targets; and 28 novel drug targets were also reported. 105 phytochemicals were linked with immunomodulatory potency by pathway level mapping in human metabolic network. A sub-network of human PPI regulated by its phytochemicals was derived and various modules in this sub-network were successfully associated with specific diseases.Graphical abstractAbbreviationsP. longumPiper longum L.PCPhytochemicalPTProtein targetBPBiological pathwaysDADisease asscociationPCtNumber of protein targets corresponding to a particular phytochemicalTtTotal number of protein targets of P. longumADMETAbsorption, Distribution, Metabolism, Excretion and Toxicity.

scholarly journals Polycystic ovarian syndrome: a curse to young women’s

2018 ◽  
Vol 5 (2) ◽  
pp. 14
Author(s):  
Noopur Srivastava ◽  
Shashi Pratap Singh ◽  
Anurag Shukla ◽  
Kanchan Lata Gupta
Keyword(s):  
Insulin Resistance ◽  
Blood Sugar ◽  
Polycystic Ovarian Syndrome ◽  
Circulatory System ◽  
Endocrine System ◽  
Symptomatic Treatment ◽  
Growth Disorders ◽  
Weight Problems ◽  
Sugar Levels ◽  
Ovarian Syndrome

The endocrine system is the group of glands that secrete hormone directly into the circulatory system moves towards distant target organs and affects them. This system release hormones that help control many important body functions. Dysfunctioning in the endocrine system may develop many disorders like diabetes, thyroid, growth disorders and sexual dysfunction. Poly cystic ovarian syndrome is one of the common endocrine disorder. PCOS is a common condition that causes a range of symptoms including irregular periods, unwanted hair growth, acne and weight problems. Increased circulating levels of testosterone can be considered as the major cause of development of polycystic ovarian syndrome. It is a male hormone, but women’s bodies make it too. Higher than normal testosterone level, makes women to experience PCOS. The physicians target on regular menstruation. In order to maintain the regular periods physicians basically administer Estrogen and Progesterone injection. Metformin is used during PCOS to treat insulin resistance developed in those women. Insulin resistance means that their bodies do not respond well to the hormone insulin that controls blood sugar levels. This causes blood sugar level to rise and this may lead to greater production of testosterone. Corticosteroids, vitamins, contraceptives pills are also prescribed for symptomatic treatment of PCOS. Changing of lifestyles may greatly help in management of poly cystic ovarian disorder. Regular exercise and weight management is the key for complete treatment of PCOS. This review contains all the information regarding PCOS.

scholarly journals Effect of Thyroid Disorder in Polycystic Ovarian Syndrome in the Women of Diyala Province

2018 ◽  
Vol 31 (1) ◽  
pp. 67
Author(s):  
Alzahraa Ibrahim Abdulmajeed
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Endocrine System ◽  
Reproductive Age ◽  
Thyroid Disorder ◽  
Pcos Woman ◽  
Common Effect ◽  
Increased Risk ◽  
Study Results ◽  
Key Factor ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the most endocrine disorder common effect (5-10) % in women at reproductive age. Thyroid dysfunction with PCOS is both representing parts of the endocrine system; this link leads to problems of ovulation and pregnancy.  Aims: to investigate the prevalence of thyroid disorder in PCOS woman, and associate the outcome with obesity. Patient and method: This study was conducted in Al-batol Teaching Hospital in Baquba City /Iraq. The results reviewed included 63 women: 45 PCOS were diagnosed on the basis of Rotterdam criteria, 18 as control, aged 17- 44 year. The samples have been collected at second day of menstrual cycle, to test fT3, fT4, fTSH in serum. Information was collected for (Age, BMI, LH, and FSH) to be part of this study. Results: A significant increasing in fT3 was found in PCOS women comparison with control pvalue>0.05. T3 showed in significant differences between lean PCOS matched against control Pvalue < 0.05, along with statistically increasing of TSH level in (lean, overweight) PCOS comparison with control pvalue˂0.05. Conclusion: PCOS is associated with hypothyroidism. Obesity or overweight is a key factor leads to increased risk of thyroid disorder.

Characteristics of Polycystic Ovarian Syndrome in Sub-fertile Woman Attending to GOPD in ShSMCH

2019 ◽  
Vol 11 (1) ◽  
pp. 17-23
Author(s):  
Jinnat Ara Islam ◽  
Fatema Ashraf ◽  
Eva Rani Nandi
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Polycystic Ovaries ◽  
Cross Sectional ◽  
Medical College ◽  
Appropriate Treatment ◽  
Pcos Group ◽  
Symptom Complex ◽  
Ovarian Syndrome ◽  
Selection Of ◽  
Fertile Women

Background: Polycystic ovarian syndrome (PCOS) is a condition characterized by menstrual abnormalities (oligo/amenorrhea) and clinical or biochemical features of hyperandrogenism and may manifest at any age. It is a common cause of female subfertility. All the dimensions of PCOS have not been yet completely explored. Methods: It was a cross sectional comparative study carried out at-GOPD of Shaheed Suhrawardy Medical College & Hospital from January, 2016 to December 2016 on 162 subfertile women. Among them 54 were PCOS group and 108 were non PCOS group. PCOS was diagnosed by (Rotterdam criteria 2003) (i) Oligo or anovulation (ii) hyperandrogenism (iii) Polycystic ovaries. Study was done to evaluate and compare the demographic characteristics, clinical, biochemical and ultrasoundgraphic features of sub-fertile women with and without PCOS. Results: A total of 162 sub-fertile women aged 16-36 years. Mean age was 29.5±5.4. There were significant differences between the two groups in terms of (oligo/amenorrhea), hirsutism, WHR and ovarian ultrasound features. There were no significant differences between two groups in correlations between the level of obesity with the incidence of anovulation, hyperandrogenism or with hormonal features. Conclusion: PCOS is one of the important factors causing Infertility. It is an ill-defined symptom complex needed due attention. There is a need to increase awareness regarding. The clinical features of PCOS are heterogenous thus can be investigated accordingly of selection of appropriate treatment modality. J Shaheed Suhrawardy Med Coll, June 2019, Vol.11(1); 17-23

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