The CAG repeat polymorphism of androgen receptor gene and prostate cancer: a meta-analysis

2011 ◽  
Vol 39 (3) ◽  
pp. 2615-2624 ◽  
Author(s):  
Mingliang Gu ◽  
Xiaoqun Dong ◽  
Xuezhi Zhang ◽  
Wenquan Niu
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Cag Repeat ◽  
Repeat Polymorphism

Association between androgen receptor gene CAG repeat polymorphism and breast cancer risk: a meta-analysis

2010 ◽  
Vol 124 (3) ◽  
pp. 815-820 ◽  
Author(s):  
YouJin Hao ◽  
Rafael Montiel ◽  
BingHui Li ◽  
Enyi Huang ◽  
Lewie Zeng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Cag Repeat ◽  
Repeat Polymorphism

SIGNIFICANCE OF THE CAG REPEAT POLYMORPHISM OF THE ANDROGEN RECEPTOR GENE IN PROSTATE CANCER PROGRESSION

2000 ◽  
Vol 164 (2) ◽  
pp. 567-572 ◽  
Author(s):  
ROBERT K. NAM ◽  
YOUSSEF ELHAJI ◽  
MURRAY D. KRAHN ◽  
JALIL HAKIMI ◽  
MINNIE HO ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Progression ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Cag Repeat ◽  
Prostate Cancer Progression ◽  
Repeat Polymorphism

Association Between Androgen Receptor Gene CAG Repeat Polymorphism and Plasma Testosterone Levels in Postmenopausal Women

2005 ◽  
Vol 12 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Ilma Simoni Brum ◽  
Poli Mara Spritzer ◽  
Franyoise Paris ◽  
Maria Augusta Maturana ◽  
Franyoise Audran ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Postmenopausal Women ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Cag Repeat ◽  
Plasma Testosterone ◽  
Repeat Polymorphism ◽  
Testosterone Levels

Association of androgen receptor gene CAG and GGN repeat polymorphism with cryptorchidism: A meta-analysis

Andrologia ◽  
2017 ◽  
Vol 50 (3) ◽  
pp. e12909 ◽  
Author(s):  
Qi Wang ◽  
Xing Ge ◽  
Heng-Xue Wang ◽  
Qiao-Mei Shi ◽  
Zhen Ding ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Polymorphism

scholarly journals Androgen Receptor Gene CAG Repeat Polymorphism in the Development of Ovarian Hyperandrogenism

2003 ◽  
Vol 88 (7) ◽  
pp. 3333-3338 ◽  
Author(s):  
Lourdes Ibáñez ◽  
Ken K. Ong ◽  
Nigel Mongan ◽  
Jarmo Jääskeläinen ◽  
Maria Victoria Marcos ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Cag Repeat ◽  
Repeat Polymorphism ◽  
Ovarian Hyperandrogenism

scholarly journals Cag Repeat Number in the Androgen Receptor Gene and Prostate Cancer

2012 ◽  
Vol 15 (1) ◽  
pp. 31-36 ◽  
Author(s):  
S Madjunkova ◽  
A Eftimov ◽  
V Georgiev ◽  
D Petrovski ◽  
A Dimovski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Cag Repeats ◽  
Repeat Number

Cag Repeat Number in the Androgen Receptor Gene and Prostate CancerProstate cancer (PC) is the second leading cause of cancer deaths in men. The effects of androgens on prostatic tissue are mediated by the androgen receptor (AR) gene. The 5' end of exon 1 of the AR gene includes a polymorphic CAG triplet repeat that numbers between 10 to 36 in the normal population. The length of the CAG repeats is inversely related to the transactivation function of the AR gene. There is controversy over association between short CAG repeat numbers in the AR gene and PC. This retrospective case-control study evaluates the possible effect of short CAG repeats on the AR gene in prostate cancer risk in Macedonian males. A total of 392 male subjects, 134 PC patients, 106 patients with benign prostatic hyperplasia (BPH) and 152 males from the general Macedonian population were enrolled in this study. The CAG repeat length was determined by fluorescent polymerase chain reaction (PCR) amplification of exon1 of the AR gene followed by capillary electrophoresis (CE) on a genetic analyzer. The mean repeat length in PC patients was 21.5 ±2.65, in controls 22.28 ±2.86 (p = 0.009) and in BPH patients 22.1 ±2.52 (p = 0.038). Short CAG repeats (<19) were found in 21.64% of PC patients vs. 9.43% in BPH patients (p = 0.0154). We also found an association of low Gleason score (<7) with short CAG repeat (<19) in PC patients (p = 0.0306), and no association between the age at diagnosis of PC and BPH and CAG repeat length. These results suggest that reduced CAG repeat length may be associated with increased prostate cancer risk in Macedonian men.

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