scholarly journals Negative association between androgen receptor gene CAG repeat polymorphism and polycystic ovary syndrome? A systematic review and meta-analysis

2012 ◽  
Vol 18 (10) ◽  
pp. 498-509 ◽  
Author(s):  
Rui Wang ◽  
Mark O. Goodarzi ◽  
Ting Xiong ◽  
Di Wang ◽  
Ricardo Azziz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Androgen Receptor ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Negative Association ◽  
Cag Repeat ◽  
Repeat Polymorphism ◽  
Ovary Syndrome

Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome

2008 ◽  
Vol 90 (6) ◽  
pp. 2318-2323 ◽  
Author(s):  
Jin Ju Kim ◽  
Seon Ha Choung ◽  
Young Min Choi ◽  
Sang Ho Yoon ◽  
Seok Hyun Kim ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Cag Repeat ◽  
Repeat Polymorphism ◽  
Ovary Syndrome

Role of the CAG Repeat Polymorphism of the Androgen Receptor Gene in Polycystic Ovary Syndrome (PCOS)

2011 ◽  
Vol 120 (02) ◽  
pp. 73-79 ◽  
Author(s):  
A. Schüring ◽  
A. Welp ◽  
J. Gromoll ◽  
M. Zitzmann ◽  
B. Sonntag ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Cag Repeats ◽  
Repeat Polymorphism ◽  
Ovary Syndrome

AbstractPolycystic ovary syndrome (PCOS) is a frequent heterogenic disorder with a familial background. Androgenic effects, determining the clinical features of the syndrome, are mediated by the androgen receptor (AR), whose activity is modulated by a genetic polymorphism. We investigated the role of the CAG repeat polymorphism of the androgen receptor in PCOS.In the infertility unit of a university clinic, 72 PCOS patients were compared with 179 ovulatory controls undergoing a standardized diagnostic work-up. The number of CAG repeats was determined by PCR, labelling with IR-800 and PAGE. X-chromosome inactivation was assessed by a methylation-sensitive assay.Compared to controls, PCOS patients displayed a shorter mean CAG repeat length, encoding for higher AR activity (P=0.001). CAG repeat length correlated inversely with oligomenorrhea, a central androgen dependent feature of the syndrome (P=0.005). In a binomial regression analysis including BMI, LH and free testosterone, CAG repeat length was identified as an independent risk factor for PCOS (P=0.002).The CAG repeat polymorphism could constitute one of the genetic factors modulating the syndrome’s phenotype, contributing to its clinical heterogeneity and associated metabolic consequences.

Association between androgen receptor gene CAG repeat polymorphism and breast cancer risk: a meta-analysis

2010 ◽  
Vol 124 (3) ◽  
pp. 815-820 ◽  
Author(s):  
YouJin Hao ◽  
Rafael Montiel ◽  
BingHui Li ◽  
Enyi Huang ◽  
Lewie Zeng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Androgen Receptor ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Cag Repeat ◽  
Repeat Polymorphism

The CAG repeat polymorphism of androgen receptor gene and prostate cancer: a meta-analysis

2011 ◽  
Vol 39 (3) ◽  
pp. 2615-2624 ◽  
Author(s):  
Mingliang Gu ◽  
Xiaoqun Dong ◽  
Xuezhi Zhang ◽  
Wenquan Niu
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Cag Repeat ◽  
Repeat Polymorphism
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