scholarly journals A Reliable Murine Model of Disseminated Infection Induced by Talaromyces Marneffei

2021 ◽  
Author(s):  
Juan He ◽  
Jia-Sheng Li ◽  
Hong-Yan Xu ◽  
Yi-Qun Kuang ◽  
Jun Li ◽  
...  
Keyword(s):  
Murine Model ◽  
Disseminated Infection ◽  
Talaromyces Marneffei

scholarly journals A reliable murine model of disseminated infection induced by Talaromyces marneffei

2021 ◽  
Author(s):  
Juan He ◽  
Jia-Sheng Li ◽  
Yi-Qun Kuang ◽  
Jun Li ◽  
Hong-Bin Li ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Murine Model ◽  
Pulmonary Infection ◽  
Skin Lesions ◽  
Pathological Changes ◽  
Good Tool ◽  
Disseminated Infection ◽  
Talaromyces Marneffei ◽  
South And Southeast Asia ◽  
Immunodeficiency Virus

Abstract Talaromycosis (penicilliosis) caused by Talaromyces marneffei is one of the most important opportunistic infection diseases in tropical countries of South and Southeast Asia. Most infections occurred in individuals with human immunodeficiency virus (HIV) and the primarily reason for the increase in the number of the cases is HIV pandemic. The pathogenesis of T. marneffei infection is unclear. There is still no ideal animal model for studying Talaromycosis. In this study, we developed a stable, safe and maneuverable murine model that mimics human T. marneffei disseminated infection using T. marneffei yeast intraperitoneal injected to BALB/c nude mice. We successfully observed symptoms similar to those seen in clinical patients in this murine model, including skin lesions, hepatosplenomegaly, pulmonary infection and mesenteric lesions. We further studied the pathological changes of various tissues and organs in the infected animals to help better understand the severity of the infection. This model may provide a good tool for studying disseminated infection induced by T. marneffei.

scholarly journals Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole

2009 ◽  
Vol 54 (2) ◽  
pp. 919-923 ◽  
Author(s):  
Enrique Calvo ◽  
F. Javier Pastor ◽  
M. Mar Rodríguez ◽  
Emilio Mayayo ◽  
Valentina Salas ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Dose Escalation ◽  
Murine Model ◽  
Antifungal Drugs ◽  
The Novel ◽  
Clinical Role ◽  
Disseminated Infection ◽  
Fonsecaea Monophora ◽  
Fungal Load ◽  
The Relationship

ABSTRACT We have evaluated the efficacy of posaconazole, amphotericin B, and itraconazole in a murine model of disseminated infection by Fonsecaea monophora. Of these three antifungal drugs tested, posaconazole prolonged survival significantly and reduced the fungal load in most of the organs tested. Bioassay studies demonstrated the relationship between posaconazole levels and dose escalation in serum and brain tissue. Posaconazole may have a clinical role in the treatment of disseminated infections by F. monophora.

scholarly journals Activities of Flucytosine, Fluconazole, Amphotericin B, and Micafungin in a Murine Model of Disseminated Infection by Candida glabrata

2005 ◽  
Vol 49 (11) ◽  
pp. 4757-4759 ◽  
Author(s):  
Marçal Mariné ◽  
Carolina Serena ◽  
Belkys Fernández-Torres ◽  
F. Javier Pastor ◽  
Josep Guarro
Keyword(s):  
Amphotericin B ◽  
Murine Model ◽  
Candida Glabrata ◽  
Disseminated Infection ◽  
Tissue Burden

ABSTRACT We compared the efficacies of amphotericin B, fluconazole, flucytosine, and micafungin in a systemic murine infection by three isolates of Candida glabrata. Amphotericin B showed the best results, although none of the drugs dramatically reduced mortality or tissue burden in liver or spleen.

scholarly journals Combined antifungal therapy in a murine model of disseminated infection byCladophialophora bantiana

2009 ◽  
Vol 47 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Marçal Mariné ◽  
F. Javier Pastor ◽  
Josep Guarro
Keyword(s):  
Antifungal Therapy ◽  
Murine Model ◽  
Disseminated Infection

scholarly journals Experimental murine model of disseminated infection bySaksenaea vasiformis: successful treatment with posaconazole

2012 ◽  
Vol 50 (7) ◽  
pp. 710-715 ◽  
Author(s):  
Valentina Salas ◽  
F. Javier Pastor ◽  
Enrique Calvo ◽  
Deanna Sutton ◽  
Dea García-Hermoso ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Murine Model ◽  
Disseminated Infection ◽  
Experimental Murine Model

scholarly journals Posaconazole Combined with Amphotericin B, an Effective Therapy for a Murine Disseminated Infection Caused by Rhizopus oryzae

2008 ◽  
Vol 52 (10) ◽  
pp. 3786-3788 ◽  
Author(s):  
M. Mar Rodríguez ◽  
Carolina Serena ◽  
Marçal Mariné ◽  
F. Javier Pastor ◽  
Josep Guarro
Keyword(s):  
Body Weight ◽  
Amphotericin B ◽  
Murine Model ◽  
Rhizopus Oryzae ◽  
Effective Therapy ◽  
Prolonged Survival ◽  
Low Doses ◽  
Disseminated Infection ◽  
Tissue Burden

ABSTRACT In a murine model of disseminated zygomycosis, low doses of amphotericin B (0.3 mg/kg body weight/day) combined with posaconazole (40 mg/kg/day) prolonged survival and reduced tissue burden with respect to that of controls and that of both drugs administered alone. Results were similar to those obtained with amphotericin B given alone at 0.8 mg/kg/day.

scholarly journals Efficacy of Amphotericin B at Suboptimal Dose Combined with Voriconazole in a Murine Model of Aspergillus fumigatus Infection with PoorIn VivoResponse to the Azole

2013 ◽  
Vol 57 (9) ◽  
pp. 4540-4542 ◽  
Author(s):  
Marcelo Sandoval-Denis ◽  
F. Javier Pastor ◽  
Javier Capilla ◽  
Josep Guarro
Keyword(s):  
Aspergillus Fumigatus ◽  
Amphotericin B ◽  
Murine Model ◽  
Combined Treatment ◽  
Content Type ◽  
Disseminated Infection ◽  
Suboptimal Dose ◽  
Tissue Burden

ABSTRACTThe combination of amphotericin B at a suboptimal dose (0.3 mg/kg) with voriconazole has shown efficacy in prolonging survival and reducing tissue burden in a murine model of disseminated infection by an isolate ofAspergillus fumigatusthat had showed a poorin vivoresponse to the azole. The efficacy of the combined treatment was higher than that obtained with amphotericin B at 0.8 mg/kg.

Antifungal susceptibility of Saccharomyces cerevisiae and therapy in a murine model of disseminated infection

2019 ◽  
Vol 36 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Alba Pérez-Cantero ◽  
Pamela Thomson ◽  
Katihuska Paredes ◽  
Josep Guarro ◽  
Javier Capilla
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Murine Model ◽  
Antifungal Susceptibility ◽  
Disseminated Infection
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