scholarly journals A reliable murine model of disseminated infection induced by Talaromyces marneffei

2021 ◽  
Author(s):  
Juan He ◽  
Jia-Sheng Li ◽  
Yi-Qun Kuang ◽  
Jun Li ◽  
Hong-Bin Li ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Murine Model ◽  
Pulmonary Infection ◽  
Skin Lesions ◽  
Pathological Changes ◽  
Good Tool ◽  
Disseminated Infection ◽  
Talaromyces Marneffei ◽  
South And Southeast Asia ◽  
Immunodeficiency Virus

Abstract Talaromycosis (penicilliosis) caused by Talaromyces marneffei is one of the most important opportunistic infection diseases in tropical countries of South and Southeast Asia. Most infections occurred in individuals with human immunodeficiency virus (HIV) and the primarily reason for the increase in the number of the cases is HIV pandemic. The pathogenesis of T. marneffei infection is unclear. There is still no ideal animal model for studying Talaromycosis. In this study, we developed a stable, safe and maneuverable murine model that mimics human T. marneffei disseminated infection using T. marneffei yeast intraperitoneal injected to BALB/c nude mice. We successfully observed symptoms similar to those seen in clinical patients in this murine model, including skin lesions, hepatosplenomegaly, pulmonary infection and mesenteric lesions. We further studied the pathological changes of various tissues and organs in the infected animals to help better understand the severity of the infection. This model may provide a good tool for studying disseminated infection induced by T. marneffei.

scholarly journals A 33-Year-Old With Human Immunodeficiency Virus/AIDS and Multiple Skin Lesions

2017 ◽  
Vol 65 (9) ◽  
pp. 1594-1594
Author(s):  
Alejandro Iregui ◽  
Edward Heilman ◽  
Michael Augenbraun ◽  
Michael Rose
Keyword(s):  
Human Immunodeficiency Virus ◽  
Skin Lesions ◽  
Immunodeficiency Virus

scholarly journals Human Immunodeficiency Virus-1 Induces Loss of Contact Inhibition in Podocytes

2001 ◽  
Vol 12 (8) ◽  
pp. 1677-1684
Author(s):  
ELISSA J. SCHWARTZ ◽  
ANDREA CARA ◽  
HANS SNOECK ◽  
MICHAEL D. ROSS ◽  
MASAAKI SUNAMOTO ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Epithelial Cells ◽  
Transgenic Mouse ◽  
Murine Model ◽  
Contact Inhibition ◽  
Direct Role ◽  
Pathologic Features ◽  
Immunodeficiency Virus ◽  
Loss Of Contact ◽  
Hiv 1

Abstract. Human immunodeficiency virus—associated nephropathy (HIVAN) affects up to 10% of HIV-positive black adults and children and is the leading cause of renal disease in infected individuals. The disease is characterized by proliferation of renal epithelial cells, both glomerular and tubular. Diseased kidneys are enlarged, and glomerular visceral epithelial cells (podocytes) express proliferation markers. In a transgenic murine model of HIVAN expressing a deletion construct of HIV-1, the identical pathologic features are observed. It was demonstrated that HIV-1 mRNA is expressed in renal epithelium of the transgenic mouse and in patients with HIVAN, suggesting a direct role for HIV-1 in disease pathogenesis in both humans and the murine model. For investigating the mechanisms responsible for proliferative changes in podocytes, the HIV-1 transgenic mouse was bred onto the immortomouse background, and conditionally immortalized transgenic and nontransgenic podocyte cell lines were established. Transgenic podocytes demonstrated increased spontaneous proliferation, compared with nontransgenic podocytes at confluence, and they were found to have a greater percentage of cells in the proliferative phase of the cell cycle. It is striking that transgenic podocytes were not contact inhibited and formed aggregates in soft agar. Aggregates also formed when nontransgenic podocytes were infected with the identical HIV-1 construct used to generate the transgenic model. This demonstrates that the loss of contact inhibition is due to a direct effect of HIV-1. Therefore, proliferation induced by HIV-1 gene expression is likely to play a key role in the pathogenesis of HIVAN.

scholarly journals Talaromycosis Marneffei pada Pasien HIV

2020 ◽  
Vol 9 (3) ◽  
pp. 373
Author(s):  
Aulia Ihsani ◽  
Raveinal Raveinal
Keyword(s):  
Human Immunodeficiency Virus ◽  
Talaromyces Marneffei ◽  
Immunodeficiency Virus

Talaromycosis marneffei adalah infeksi jamur yang disebabkan Talaromyces marneffei. Talaromikosis adalah salah satu infeksi oportunistik yang sering mengenai orang dengan infeksi Human Immunodeficiency Virus (HIV) stadium akhir di Asia Tenggara, India timur laut, Cina Selatan, Hongkong, dan Taiwan. Gejala klinis talaromikosis tidak spesifik, seperti demam, anemia, penurunan berat badan, hepatomegali, splenomegali, gangguan pernapasan dan manifestasi kulit. Diagnosis ditegakkan berdasarkan kecurigaan klinis dengan konfirmasi pemeriksaan histopatologi. Dilaporkan pasien laki-laki berusia 29 tahun, dirawat di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang, dengan keluhan utama muncul bintil-bintil berwarna kehitaman hampir diseluruh wajah sejak 3 bulan yang lalu. Pasien sudah dikenal menderita HIV sejak 4 bulan yang lalu dan sudah mendapat terapi antiretroviral (ARV). Didapatkan plak hiperpigmentasi pada wajah dan hepatomegali. Laboratorium didapatkan kadar hemoglobin 8,9 gr/dl, CD4 8 sel/uL dan pemeriksaan histopatologi yang menunjukkan massa sporis eosinofilik di intraseluler dan diantara stroma jaringan ikat. Pemberian ARV dilanjutkan dan juga diberikan antijamur.Kata kunci: human immunodeficiency virus, talaromycosis, talaromyces marneffei

scholarly journals Mixed Infection Caused by Two Species ofFusarium in a Human Immunodeficiency Virus-Positive Patient

2000 ◽  
Vol 38 (9) ◽  
pp. 3460-3462 ◽  
Author(s):  
Josep Guarro ◽  
Marcio Nucci ◽  
Tiyomi Akiti ◽  
Josepa Gené
Keyword(s):  
Human Immunodeficiency Virus ◽  
Mixed Infection ◽  
Fusarium Solani ◽  
Skin Lesions ◽  
Fungal Species ◽  
Accurate Diagnosis ◽  
Positive Patient ◽  
Immunosuppressed Patient ◽  
Immunodeficiency Virus

We report on a case of mixed infection caused by two species ofFusarium in a human immunodeficiency virus-positive patient with lymphoma who was neutropenic due to chemotherapy. The patient showed the typical signs of a disseminated fusarial infection, withFusarium solani isolated from skin lesions and F. verticillioides isolated from blood. The report discusses how difficult it is to make an accurate diagnosis when an immunosuppressed patient is infected with more than one fungal species, especially when the species are morphologically very similar.

scholarly journals Blindness in a Woman With Human Immunodeficiency Virus Infection and Syphilis

1995 ◽  
Vol 3 (5) ◽  
pp. 198-201
Author(s):  
Michael Luchi ◽  
Curtis Beauregard ◽  
Kevin Ault ◽  
Daniel Hinthorn
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cerebrospinal Fluid ◽  
Virus Infection ◽  
Hiv Infection ◽  
Skin Lesions ◽  
High Dose ◽  
Progressive Loss ◽  
Immunodeficiency Virus ◽  
History Of ◽  
Hands And Feet

Background: A concomitant infection with human immunodeficiency virus (HIV) may alter the natural history of other infections. Several reports indicate that syphilis may behave more aggressively when HIV infection is present.Case: A woman presented with a rash involving her hands and feet and progressive loss of the vision in her right eye. Her serologic tests for syphilis and HIV infection were positive. A diagnosis of neurosyphilis was confirmed by an analysis of cerebrospinal fluid (CSF). She was treated with high-dose intravenous (IV) penicillin. Her skin lesions resolved, but her vision did not improve.Conclusion: The incidence of HIV infection among women is rising. A patient with HIV and syphilis may develop neurosyphilis in a much shorter time than a patient without HIV infection.

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