Treatment strategies and long-term outcomes for primary intramedullary spinal germinomas: an institutional experience

2014 ◽  
Vol 121 (3) ◽  
pp. 541-548 ◽  
Author(s):  
Liang Wu ◽  
Tao Yang ◽  
Xiaofeng Deng ◽  
Chenlong Yang ◽  
Jingyi Fang ◽  
...  
2006 ◽  
Vol 192 (4) ◽  
pp. 492-495 ◽  
Author(s):  
Adora Fou ◽  
Freya R. Schnabel ◽  
Diane Hamele-Bena ◽  
Xiao-Jun Wei ◽  
Bin Cheng ◽  
...  

2020 ◽  
Vol 59 (5) ◽  
pp. e31
Author(s):  
Safa Salim ◽  
Rossella Locci ◽  
Guy Martin ◽  
Rick Gibbs ◽  
Michael Jenkins ◽  
...  

2018 ◽  
Vol 29 (05) ◽  
pp. 412-416
Author(s):  
Riccardo Coletta ◽  
Bashar Aldeiri ◽  
Antonino Morabito

Aim The aim of this study was to report our initial experience using spiral intestinal lengthening and tailoring (SILT) technique in selected cases of short bowel syndrome (SBS). Materials and Methods We analyzed all cases of SBS underwent SILT in our unit since the introduction of the procedure in 2012. We retrospectively analyzed patients' demographics, pre- and postprocedure bowel length, surgical complications, and postoperative parenteral nutrition (PN) requirements. Data were compared using independent samples, Mann–Whitney's U-test. Results Five children with SBS underwent SILT between 2012 and 2017. Median age at procedure was 8.3 months (4.5–16). Preoperative small bowel length measured a median of 22 cm (17.5–50) with a median diameter of 4 cm (3.5–4.6). SILT allowed a median increase in length of 56% (10–15 cm; p = 0.03) and tailoring of the dilated segment providing a reduction in diameter of 50% (4.3–2.1 cm; p = 0.01). No major complications related to SILT were encountered and none of the children required further surgical intervention following a median follow-up of 26 months (14.5–41). Interestingly, we observed a significant reduction of PN requirement at 6 months (p = 0.008) associated with liver function preservation during the follow-up period. Conclusion In our experience, SILT is a promising adjunct in the surgical management of SBS. It can be used to tailor and lengthen mildly dilated segments of the bowel where other procedures are technically challenging, with a view to reduce the risk of intestinal failure associated liver disease and thereby improving chances for quality survival. Further studies are needed to investigate long-term outcomes of SILT in pediatric SBS.


Author(s):  
Rohan Savoor ◽  
Timothy L. Sita ◽  
Nader S. Dahdaleh ◽  
Irene Helenowski ◽  
John A. Kalapurakal ◽  
...  

Author(s):  
Lisa M. Bebell

Congenital and pediatric Ebola virus disease (EVD) and Marburg virus disease (MVD) are severe, even lethal infections. Historically, children have been underrepresented in filovirus disease outbreaks, and evidence-based treatment strategies are lacking. Existing data suggest that case fatalities are highest among children under four years of age, which is partially explained by higher virus concentrations in young children. Prevention and aggressive resuscitation, nutrition, and supportive care are the mainstays of management until filovirus-specific therapies can be developed. Differences in pediatric immune and inflammatory responses may necessitate unique approaches to pediatric vaccination and treatment. There are minimal safety or immunogenicity data in children, a crucial knowledge gap that must be addressed in future trials. Studying pediatric survivors of the 2014–2016 West Africa EVD outbreak will provide much-needed data on long-term outcomes and residual effects of filovirus disease while we await effective filovirus-specific vaccines and therapies.


2018 ◽  
pp. 231-236
Author(s):  
Samuel W. Samuel ◽  
Eduardo E. Icaza

This chapter discusses cervical radiculopathy, a common, painful condition from cervical root compression, irritation, or both. A thorough history and physical exam can often help in diagnosing the affected nerve root, without the need for reflexive imaging. A series of provocative tests can aid in the differential diagnosis. Most cases will be resolved with conservative management within several weeks of symptoms onset. Evidence-based conservative management includes physical therapy and oral NSAIDs. If symptoms indicate myelopathic changes or are refractory to 6 to 8 weeks of conservative management, advanced imaging such as MRI should be considered. Patients with imaging evidence of a compressive etiology and refractory to conservative therapy should have a surgical consultation. Either an MRI or CT should be obtained before surgical decompression. Both interventional and surgical treatments have had positive outcomes in the short term, but long-term outcomes appear comparable to those with conservative therapies. It is recommended that conservative treatment strategies be used for 6–8 weeks before pursuing procedural or surgical intervention.


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