Comparing pre-operative stereotactic radiosurgery (SRS) to post-operative whole brain radiation therapy (WBRT) for resectable brain metastases: a multi-institutional analysis

2016 ◽  
Vol 131 (3) ◽  
pp. 611-618 ◽  
Author(s):  
Kirtesh R. Patel ◽  
Stuart H. Burri ◽  
Danielle Boselli ◽  
James T. Symanowski ◽  
Anthony L. Asher ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Institutional Analysis ◽  
Whole Brain Radiation Therapy ◽  
Whole Brain ◽  
Whole Brain Radiation ◽  
Brain Radiation

scholarly journals The Rationale for Adjuvant Whole Brain Radiation Therapy with Radiosurgery in the Treatment of Single Brain Metastases

2003 ◽  
Vol 2 (2) ◽  
pp. 111-115 ◽  
Author(s):  
Roy A. Patchell ◽  
William F. Regine
Keyword(s):  
Radiation Therapy ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Scientific Evidence ◽  
Focal Therapy ◽  
Whole Brain Radiation Therapy ◽  
Conventional Surgery ◽  
Whole Brain ◽  
Whole Brain Radiation ◽  
Brain Radiation

Randomized trials have established the efficacy of focal treatment (either stereotactic radiosurgery or conventional surgery) for single brain metastases. In the past, adjuvant whole brain radiation therapy (WBRT) was routinely given with focal therapy. Recently, the utility of adjuvant WBRT has been called into question. This paper examines the scientific evidence and the arguments, pro and con, concerning the use of adjuvant WBRT in association with stereotactic radiosurgery or conventional surgery.

scholarly journals Stereotactic Radiosurgery for Treatment of Brain Metastases

2016 ◽  
Vol 12 (8) ◽  
pp. 703-712 ◽  
Author(s):  
Shahed N. Badiyan ◽  
William F. Regine ◽  
Minesh Mehta
Keyword(s):  
Radiation Therapy ◽  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Whole Brain Radiation Therapy ◽  
Published Data ◽  
Whole Brain ◽  
Noninvasive Treatment ◽  
Whole Brain Radiation ◽  
Brain Radiation ◽  
Systemic Therapies

Brain metastases are the most common intracranial malignancy. Incidence of brain metastases has risen as systemic therapies have improved and patients with metastatic disease live longer. Whole-brain radiation therapy, for many years, has been the standard treatment approach. Stereotactic radiosurgery has become an increasingly popular option because of its relatively short, convenient, and noninvasive treatment course. Although recently published data have renewed interest in use of whole-brain radiation therapy or systemic therapies for control of micrometastatic disease, stereotactic radiosurgery continues to be an important modality, capable of delivering ablative doses of radiation for long-term control of macroscopic disease. The purpose of this review is to explore the different paradigms for incorporation of stereotactic radiosurgery into management of brain metastases. Current uses for stereotactic radiosurgery include delivery as a boost with whole-brain radiation therapy; alone for patients with a limited number of brain metastases; in pre- or postoperative settings; and in combination with systemic, targeted, and immune-based therapies. Mature prospective data on use of stereotactic radiosurgery in combination with whole-brain radiation therapy is available; however, prospective, randomized data on stereotactic radiosurgery for patients with a greater number of brain metastases, its use in pre- and postoperative settings, and its use in combination with systemic therapies are limited. Data from ongoing and future studies are needed to define the appropriate use of stereotactic radiosurgery in these settings.

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